Scarring alopecias (i.e. lichen planopilaris, frontal fibrosing alopecia, central centrifugal cicatricial alopecia, chronic cutaneous lupus erythematosus) are a collection of hair loss disorders in which hair follicles (HF) are destroyed and replaced with scar tissue, resulting into permanent hair loss.

We are happy to announce that we have established comprehensive techniques for pre-clinical research on scarring alopecias. We can model scarring alopecia-like phenotypes in ex vivo organ culture of human hair follicles and human full thickness scalp skin which display all typical characteristics of the diseases, including immune privilege collapse of the bulge, loss of HF stem cells, and epithelial-to-mesenchymal transition. Additionally, we have access to lesional patient samples from our Monasterium Laboratory Biobank.

All our models are ideal to investigate mechanisms of action, identify biomarkers, characterize new therapeutic targets, predict responses or assess the effects of compounds, formulations or drugs on the scarring alopecia phenotype before entering clinical trials.

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Related publications: Senna et al. (2022)Piccini et al. (2020)Cheret et al. (2020)Imanishi et al. (2018).