Publications - Monasterium Laboratory

Our Publications

= Highlight publication

Year	Title	Author	Journal	Link	Keywords
2023	Laser capture microdissection as a method for investigating the human hair follicle microbiome reveals region-specific differences in the bacteriome profile	Lousada MB, Edelkamp J, Lachnit T, Fehrholz M, Jimenez F, Paus R	BMC Research Notes	read the full story	Hair follicle organ culture, Microbiome, Laser-Capture Microdissection
2023	Involvement of ILC1-like innate lymphocytes in human autoimmunity: lessons from alopecia areata	Laufer Britva R, Keren A, Bertolini M, Ullmann Y, Paus R, Gilhar A	eLife	read the full story	Alopecia Areata, Hair Loss, Hair growth, Humanized mouse model, innate lymphoid cells-type 1
2023	Application of topical Sandalore® increases epidermal dermcidin synthesis in organ-cultured human skin ex vivo	Edelkamp J, Lousada MB, Pinto D, Chéret J, O'Sullivan JDB, Biundo A, Jimenez F, Funk W, Roessing C, Rippmann V, Paus R, Bertolini M	Skin Pharmacol. Physiol.	read the full story	Skin organ culture, Chemosensation, Olfactory Receptors, Microbiome, Antimicrobial peptides
2023	Concentration-dependent stimulation of melanin production as well as melanocyte and keratinocyte proliferation by melatonin in human eyelid epidermis	Sevilla A, Chéret J, Lee W, Paus R	Exp. Dermatol.	read the full story	Full-thickness eyelid skin organ culture, melatonin, melanogenesis,
2023	Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants	Keren A, Reich K, Bertolini M, Moga A, Riethmüller C, Ullmann Y, Paus R, Gilhar A	Allergy	read the full story	Atopic Dermatitis; humanized mouse model; xenotransplants; skin barrier deficits
2022	Human Hair Follicles Operate a Functional Peripheral Equivalent of the Hypothalamic-Pituitary-Somatotropic Axis Ex Vivo	Horesh EJ, Gherardini J, Alam M, Rodriguez-Feliz J, Bauman AJ, Chéret J, Paus R	JID	read the full story	HF organ culture ex vivo; HPS-Axis; brain-HF-axis; neuroendocrinology
2022	Downregulation of pathogenic MICA-NKG2D interactions as a novel strategy in alopecia areata management: a new rationale for adjunct statin therapy?	Gherardini J, Rivas KE, Chéret J, Strbo N, Paus R	JEADV	read the full story	Outer Root Sheath Keratinocytes; in vitro models, Alopecia Areata; IP collapse
2022	Mitochondrially Localized MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte Proliferation	Wikramanayake TC, Nicu C, Gherardini J, Mello ACGCV, Chéret J, Paus R	JID	read the full story	Sebaceous gland function, MPZL3
2022	The impact of perceived stress on the hair follicle: Towards solving a psychoneuroendocrine and neuroimmunological puzzle	O'Sullivan JDB , Peters EMJ, Amer Y, Atuluru P, Chéret J, Rosenberg AM, Picard M, Paus R	Front Neuroendocrinol.	read the full story	brain-HF axis; perceived stress in hair greying and hair loss, neuroendocrinology
2022	Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactions	Platt CI, Cheret J, Paus R	Arch Dermatol Res.	read the full story	Organotypic model, 3D dermal papilla spheroids, Epithelial mesenchymal interaction, hair matrix
2022	A plaidoyer for the use of human skin xenotransplant mouse models in preclinical psoriasis research	Gilhar A, Reich K, Keren A, Paus R	J Eur Acad Dermatol Venereol.	read the full story	Psoriasis, humanized mouse model, xenotransplantation
2022	Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype	Piccini I, Sousa M, Altendorf S, Jimenez F, Rossi A, Funk W, Biró T, Paus R, Seibel J, Jakobs M, Yesilkaya T, Edelkamp J, Bertolini M	Nutrients.	read the full story	Female pattern hair loss, hair follicle, metabolism, nutrient supplementation
2022	Circadian rhythms in psoriasis and the potential of chronotherapy in psoriasis management	Luengas-Martinez A, Paus R, Iqbal M, Bailey L, Ray DW, Young HS	Exp. Dermatol	read the full story	VEGF-A, chronotherapy, circadian rhythms, psoriasis.
2022	Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational Horizons	Senna MM, Peterson E, Jozic I, Chéret J, Paus R	JID Innov.	read the full story	5α-reductase inhibitor, alopecia areata, androgenetic alopecia, corticotropin-releasing hormone, epithelial‒mesenchymal transition, frontal fibrosing alopecia, hair follicle, immune privilege, keratin, keratinocyte, lichen planopilaris, macrophage, major histocompatibility complex, primary cicatricial alopecia, personal care product, peroxisome proliferator–activated receptor-γ, stem cell, substance P, epithelial hair follicle stem cell, α-melanocyte-stimulating hormone
2022	Hydra and the hair follicle - An unconventional comparative biology approach to exploring the human holobiont	Lousada MB, Lachnit T, Edelkamp J, Paus R, Bosch TCG	Bioessays.	read the full story	Antimicrobial peptides, microbial ecology, microbiome, model organisms
2022	Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging	Wikramanayake TC, Chéret J, Sevilla A, Birch-Machin M, Paus R	Expert opinion on Therapeutic Targets	read the full story	Reactive oxygen species (ROS), alopecia, appendage, epidermis, hair follicle, mitochondria, myelin protein zero-like 3 (MPZL3), sebaceous gland, skin cancer
2022	Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective	Sevilla A, Chéret J, Slominski RM, Slominski AT, Paus R	J. Pineal res	read the full story	Hair follicle, human skin, melanocyte, melatonin, pigmentation
2022	An extract of Leontopodium alpinum inhibits catagen development ex vivo and increases hair density in vivo	Campiche R, Le Riche A, Edelkamp J, Fernandez Botello A, Martin E, Gempeler M, Bertolini M	Int J Cosmet Sci.	read the full story	Leontopodium alpinum, anagen phase, anti-hair loss, hair follicle, hair growth, versican
2022	Human organ reju-venation by VEGF-A: Lessons from the skin	Keren A, Bertolini M, Yaniv K, Ullmann Y, Paus R, Gilhar A	Sci. Advances	read the full story	VEGF-A, skin aging, skin rejuvenation, humanized mouse model, skin organ culture ex vivo
2022	Effect of minoxidil formulations on human scalp skin xenotransplants on SCID mice: A novel pre-clinical in vivo assay for androgenetic alopecia research	Gilhar A, Keren A, Ullmann Y, Wu J, Paus R	Exp Dermatol.	read the full story	Mouse model, xenotransplant, preclinical model, hair growth, hair loss, androgenetic alopecia
2022	Growth Hormone and the Human Hair Follicle	Horesh E.J, Chéret J, Paus R	Int J Mol Sci.	read the full story	Growth hormone, neuroendocrine, hair follicle, hair growth
2021	The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendages	Yue ZC, Lei MX, Paus R, Chuong CM	Biol Rev Camb Philos Soc.	read the full story	VEGF, psoriasis, therapeutic strategies
2021	Adiponectin negatively regulates pigmentation, Wnt/β-catenin and HGF/c-Met signalling within human scalp hair follicles ex vivo	Nicu C, Jackson J, Shahmalak A, Pople J, Ansell D, Paus R	Arch Dermatol Res.	read the full story	hair follicle, adiponectin, pigmentation, hair follicle organ culture, ex vivo, dermal papilla, WNT
2021	Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldness	Hochfeld L.M, Bertolini M, Broadley D, Botchkareva N.V, Betz R.C, Schoch S, Nöthen M.M, Heilmann-Heimbach S.	PLoS One.	read the full story	hair follicle, male pattern hair loss, WNT, genetic
2021	Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase	Figlak k, Williams G, Bertolini M, Paus R, Philpott M.P.	Sci Rep.	read the full story	hair follicle, metabolism, outer root sheath keratinocytes, hair follicle organ culture, ex vivo
2021	Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle	Uchida Y, Gherardini J, Pappelbaum K, Chéret J, Schulte-Mecklenbeck A, Gross CC, Strbo N, Gilhar A, Rossi A, Funk W, Kanekura T, Almeida L, Bertolini M, Paus R.	J Autoimmun.	read the full story	alopecia areata, autoimmunity, resident human γδT-cells, hair follicle, MICA, NKG2D, stress, ex vivo model
2021	The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targets	Suzuki T, Ito T, Gilhar A, Tokura Y, Reich K, Paus R.	Exp Dermatol.	read the full story	hair growth, skin, psoriasis, hair follicle
2021	PPARγ signaling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transition	Piccini I, Brunken L, Chéret J, Ghatak S, Ramot Y, Alam M, Purba TS, Hardman J, Erdmann H, Jimenez F, Paus R, Bertolini M.	Br J Dermatol.	read the full story	alopecia, chemotherapy, treatment, prevention, PPARγ agonist
2021	Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology.	Wikramanayake TC, Nicu C, Chéret J, Czyzyk TA, Paus R.	Bioessays.	read the full story	Myelin Protein Zero-like 3, CLOCK, PPARγ, mitochondria
2021	A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism?	Limbu SL, Purba TS, Harries M, Wikramanayake TC, Miteva M, Bhogal RK, O'Neill CA, Paus R.	Bioessays.	read the full story	dandruff, scalp, hair follicle, cosmeceuticals
2021	Quantitative mapping of human hair greying and reversal in relation to life stress	Rosenberg AM, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Kumar Soni R, Lacefield C, Tobin DJ, Paus R, Picard M.	Elife.	read the full story	stress, premature greying, hair shaft proteomics
2021	A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?	Ivan Jozic, Jérémy Chéret, Beatriz Abdo Abujamra, Mariya Miteva, Jennifer Gherardini, Ralf Paus	Biomedicines	read the full story	caveolin-1, scarring alopecia, hair follicle stem cells, immune privilege collapse
2021	Sensory re-innervation of human skin by human neural stem cell-derived peripheral neurons ex vivo	Chéret J, Piccini I, Gherardini J, Ponce L, Bertolini M, Paus R.	J Invest Dermatol.	read the full story	skin explants, re-innervation, iPS cells
2021	Transduction-induced overexpression of Merkel cell T antigens in human hair follicles induces formation of pathological cell clusters with Merkel cell carcinoma-like phenotype	Thibault Kervarrec, Jérémy Chéret, Ralf Paus, Roland Houben, David Schrama	Exp Dermatol.	read the full story	Merkel cells, carcinoma, polyomavirus, hair follicle, malignant transformation, tumor
2021	Can antibiotic-induced changes in the composition of the hair follicle microbiome regulate human hair growth?	Bispo Lousada M, Edelkamp J, Lachnit T, Erdmann H, Paus R	Exp Dermatol.	read the full story	microbiome, hair growth, hair follicle
2021	UDP-GlcNAc-1-phosphotransferase is a clinically important regulator of human and mouse hair pigmentation	Tiede S, Hundt JE, Paus R	J Invest Dermatol.	read the full story	hair follicle, pigmentation, therapeutics, greying
2021	Quantitative mapping of human hair greying and reversal in relation to life stress	Rosenberg AM, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Kumar Soni R, Lacefield C, Tobin DJ, Paus R, Picard M	Elife.	read the full story	hair follicle, greying, pigmentation, stress
2021	Sensory re-innervation of human skin by human neural stem cell-derived peripheral neurons ex vivo	Chéret J, Piccini I, Gherardini J, Ponce L, Bertolini M, Paus R	J Invest Dermatol.	read the full story	model, skin re-innervation, itch irritation
2021	A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?	Jozic I, Chéret J, Abujamra BA, Miteva M, Gherardini J, Paus R	Biomedicines.	read the full story	hair follicle, alopecia target, frontal fibrosing alopecia
2021	Pathobiology questions raised by telogen effluvium and trichodynia in COVID-19 patients	Di Landro A, Naldi L, Glaser E, Paus R, Tosti A	Exp Dermatol.	read the full story	Continuous Positive Airway Pressure, paracetamol, systemic steroids, anticoagulants, clinical manifestations
2021	Stress and Nasal Allergy: Corticotropin-Releasing Hormone Stimulates Mast Cell Degranulation and Proliferation in Human Nasal Mucosa	Yamanaka-Takaichi M, Mizukami Y, Sugawara K, Sunami K, Teranishi Y, Kira Y, Paus R, Tsuruta D	Int J Mol Sci.	read the full story	inflammation, stem cell factor, antalarmin, therapeutics
2021	Hair follicle chemosensation: TRPM5 signalling is required for anagen maintenance	Mardaryev A, van Lessen M, Alam M, Acosta FJ, Bíró T, Paus R	J Invest Dermatol.	read the full story	hair cycle, hair follicle, triphenylphosphine oxide, TRPM5
2021	Beyond the NFAT Horizon: From Cyclosporine A-Induced Adverse Skin Effects to Novel Therapeutics	Hawkshaw NJ, Paus R	Trends Pharmacol Sci.	read the full story	hypertrichosis, human model systems, immunosuppressive therapy
2021	The biology of human hair greying	O'Sullivan JDB, Nicu C, Picard M, Chéret J, Bedogni B, Tobin DJ, Paus R	Biol Rev Camb Philos Soc.	read the full story	melanogenesis, bulge melanocyte stem cells, pigmentation, HFPU melanocyte survival
2021	Inhibition of Shh Signaling through MAPK Activation Controls Chemotherapy-Induced Alopecia	Haslam IS, Zhou G, Xie G, Teng X, Ao X, Yan Z, Smart E, Rutkowski D, Wierzbicka J, Zhou Y, Huang Z, Zhang Y, Farjo N, Farjo B, Paus R, Yue Z	J Invest Dermatol.	read the full story	antimitotic, apoptosis-promoting, MAPK-Shh axis
2021	Compartmentalised metabolic programmes in human anagen hair follicles: New targets to modulate epithelial stem cell behaviour, keratinocyte proliferation and hair follicle immune status?	Purba TS, Berriche L, Paus R	Exp Dermatol.	read the full story	Warburg effect, hair growth, immunological HF microenvironment
2021	Human epithelial stem cell survival within their niche requires "tonic" cannabinoid receptor 1-signaling - Lessons from the hair follicle	Sugawara K, Zákány N, Tiede S, Purba T, Harries M, Tsuruta D, Bíró T, Paus R	Exp Dermatol.	read the full story	endocannabinoid system, organ-cultured human HFs, human adult epithelial stem cell
2021	Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research	Stone RC, Aviv A, Paus R	J Invest Dermatol.	read the full story	pigmentary unit, chemotherapy-induced alopecia, telogen effluvium, androgenetic alopecia, cicatricial alopecia
2021	Dermal adipose tissue secretes HGF to promote human hair growth and pigmentation	Nicu C, O'Sullivan JDB, Ramos R, Timperi L, Lai T, Farjo N, Farjo B, Pople J, Bhogal R, Hardman JA, Plikus MV, Ansell DM, Paus R	J Invest Dermatol.	read the full story	hepatocyte growth factor, human HF-dWAT co-culture, human hair growth, pigmentation
2021	Shining a (blue) light on hair follicle chronobiology and photobiomodulation	Paus R	Exp Dermatol.	read the full story	hair follicles, metabolism, clock gene
2021	Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactions	Platt CI, Chéret J, Paus R	Arch Dermatol Res.	read the full story	microdissected scalp hair follicles, dermal papilla, 3-dimensional (3D) spheroids
2021	Translational Neuroendocrinology of Human Skin: Concepts and Perspectives	Ramot Y, Böhm M, Paus R	Trends Mol Med.	read the full story	neurohormones, neuropeptides, neurotransmitters, human skin physiology
2020	Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model	Gilhar A, Laufer Britva R, Keren A, Paus R	J Investig Dermatol	read the full story	alopecia areata, therapeutic effects, preclinical
2020	The Evolving Pathogenesis of Alopecia Areata: Major Open Questions	Paus R	J Investig Dermatol.	read the full story	autoimmune alopecia areata, atopic dermatitis, hair follicle
2020	Mouse models of atopic dermatitis: a critical reappraisal	Gilhar A, Reich K, Keren A, Kabashima K, Steinhoff M, Paus R	Exp Dermatol.	read the full story	atopic dermatitis, human skin xenotransplants, SCID mice
2020	Towards a renaissance of dermatoendocrinology: Selected current frontiers	Böhm M, Paus R	Exp Dermatol.	read the full story
2020	Re-innervation of human skin by rat dorsal root ganglia permits to study interactions between sensory nerve fibers and native human dermal mast cells ex vivo	Chéret J, Ponce L, Le Gall-Ianotto C, Bertolini M, Paus R	Exp. Dermatol.	read the full story	human skin organ culture, functional sensory skin nerves, neurogenic skin inflammation
2020	Clues that mitochondria are involved in the hair cycle clock: MPZL3 regulates entry into and progression of murine hair follicle cycling	Nicu C, Wikramanayake TC, Paus R	Exp. Dermatol.	read the full story	intrinsic oscillator system, myelin protein zero- like 3, telogen‐to‐anagen transition
2020	Pro-inflammatory Vδ1 + T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles	Uchida Y, Gherardini J, Schulte-Mecklenbeck A, Alam M, Chéret J, Rossi A, Kanekura T, Gross CC, Arakawa A, Gilhar A, Bertolini M, Paus R	J Dermatol Sci.	read the full story	skin-resident γδT-cells, alopecia areata, hair follicle, innate immunity
2020	The Hair Follicle as an Interdisciplinary Model for Biomedical Research: An Eclectic Literature Synthesis	Haslam IS, Paus R	Bioessays	read the full story	human hair growth, regeneration, hair loss therapy, stem cell niches
2020	Translational Neuroendocrinology of Human Skin: Concepts and Perspectives	Ramot Y, Böhm M, Paus R	Trends Mol Med.	read the full story	neurohormones, inflammatory skin, neuropeptides
2020	The biology of human hair greying	O'Sullivan JDB, Nicu C, Picard M, Chéret J, Bedogni B, Tobin DJ, Paus R	Biol Rev Camb Philos Soc.	read the full story	anagen, hair follicle pigmentary unit, bulge melanocyte stem cells,
2020	A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo	Bertolini M, Chéret J, Pinto D, Hawkshaw N, Ponce L, Erdmann H, Jimenez F, Funk W, Paus R	Br J Dermatol.	read the full story	Wnt signalling, hair growth, hypertrichosis, catagen development
2020	Does dysfunctional autophagy contribute to immune privilege collapse and alopecia areata pathogenesis?	Hardman JA, Nicu C, Tai C, Harries M, Mironov A, Purba TS, Paus R	J Dermatol. Sci.	read the full story	autophagy, lysosomal degradation, ATG5, catagen,
2020	Exploring the human hair follicle microbiome	Lousada MB, Lachnit T, Edelkamp J, Rouillé T, Ajdic D, Uchida Y, Di Nardo A, Bosch TCG, Paus R	Br. J Dermatol.	read the full story	microbiota, human holobiont, antimicrobial peptides, microbial survival
2020	Inhibition of sonic hedgehog signaling via MAPK activation controls chemotherapy-induced alopecia	Haslam IS, Zhou G, Xie G, Teng X, Ao X, Yan Z, Smart E, Rutkowski D, Wierzbicka J, Zhou Y, Huang Z, Zhang Y, Farjo N, Farjo B, Paus R, Yue Z	J Invest Dermatol.	read the full story	clinical oncology, hair matrix keratinocytes, Shh signaling, hair follicle damage
2020	Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?	Paus R, Ramot Y, Kirsner RS, Tomic-Canic M	Exp. Dermatol.	read the full story	topical hormone therapy, thyroid hormone receptor, L‐thyroxine (T4), skin ulcers, telogen effluvium
2020	Hair follicle immune privilege and its collapse in alopecia areata	Bertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus R	Exp. Dermatol.	read the full story	MHC class, mast cells, CD4+, CD8+, NK cell, disease relapse
2020	Topical Odorant Application of the Specific Olfactory Receptor OR2AT4 Agonist, Sandalore ® , Improves Telogen Effluvium-Associated Parameters	Jimenez F, López E, Bertolini M, Alam M, Chéret J, Westgate G, Rinaldi F, Marzani B, Paus R.	J Cosmet Dermatol.	read the full story	OR2AT4 olfactory receptor, Sandalore®, claim substantiation, hair growth, hair treatment, telogen effluvium
2020	Vascular Endothelial Growth factor-A as a Promising Therapeutic Target for the Management of Psoriasis	Luengas-Martinez A, Hardman-Smart J, Paus R, Young HS.	Exp. Dermatol.	read the full story	angiogenic mediator, bevacizumab, personalised medicine, vascular endothelial growth factor A
2020	Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under "pathological" conditions ex vivo	Post H, Hundt JE, Zhang G, Depping R, Rose C, Langan EA, Paus R.	Arch Dermatol. Res	read the full story	hypoxia, skin organ culture, Wound healing, preclinical
2020	Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?	Paus R, Ramot Y, Kirsner RS, Tomic-Canic M	Exp Dermatol.	read the full story	nuclear hormone receptors, wound healing, hair growth, telogen effluvium, triiodothyronine
2020	Does mitochondrial dysfunction of hair follicle epithelial stem cells play a role in the pathobiology of lichen planopilaris?	Hardman-Smart JA, Purba TS, Panicker S, Farjo B, Farjo N, Harries MJ, Paus R.	Br J Dermatol.	read the full story	T- cell mediated interferon-γ, immune privilege,
2020	Vascular endothelial growth factor blockade induces dermal endothelial cell apoptosis in a clinically relevant skin organ culture model	Luengas-Martinez A, Hardman-Smart J, Rutkowski D, Purba TS, Paus R, Young HS	Skin Pharmacol Physiol	read the full story	anti-VEGF, endothelial cell apoptosis, human skin ex vivo, microvascular network, Psoriasis
2020	Non‐neuronal kappa‐opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex vivo	Chéret J, Gherardini J, Soeberdt M, Hundt JE, Abels C, Bertolini M, Paus R	J Dermatol	read the full story	neurogenic inflammation, human skin organ culture, keratinocyte apoptosis, inflammatory dermatoses
2020	Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis	Oláh A, Alam M, Chéret J, Kis NG, Hegyi Z, Szöllősi AG, Vidali S, Bíró T, Paus R	Exp Dermatol	read the full story	keratinocyte mitochondrial activity, cannabinoid receptor 1, organ-cultured full-thickness human skin, ROS production, skin aging, photodamage
2020	Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 Skewing	Del Duca E, Ruano Ruiz J, Pavel AB, Sanyal RD, Song T, Gay-Mimbrera J, Zhang N, Estrada YD, Peng X, Renert-Yuval Y, Phelps RG, Paus R, Krueger JG, Guttman-Yassky E.	Br J Dermatol	read the full story	lesional, nonlesional scalp biopsies, stem cells, follicular damage, JAK/STAT-targeting treatments
2020	Hair(y) matters in melanoma biology	Barbara Bedogni, Ralf Paus	Trends in Molecular Medicine	read the full story	metastatic melanoma, melanocytes, immune-privileged microenvironment, stem cells, melanoma prevention strategy
2020	New effects of caffeine on CRH-induced stress along the intrafollicular classical HPA-axis (CRH-R1/2, IP3 -R, ACTH, MC-R2) and the neurogenic non-HPA-axis (substance P, p75NTR and TrkA) in ex vivo human male androgenetic scalp hair follicles.	Fischer TW, Bergmann A, Kruse N, Kleszczynski K, Skobowiat C, Slominski AT, Paus R	Br J Dermatol	read the full story	human hair, androgenetic alopecia, stress-induced hair loss, hair organ culture model, caffeine
2020	An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytes	Alam M, Bertolini M, Gherardini J, Keren A, Ponce L, Chéret J, Alenfall J, Dunér P, Nilsson AH, Gilhar A, Paus R	Br J Dermatol	read the full story	human scalp skin xenotransplant, human hair follicle organ culture, hypertrichosis, hirsutism, hair growth
2020	Adenosine promotes human hair growth and inhibits catagen transition in vitro - role of the outer sheath keratinocytes.	Lisztes E, Toth BI, Bertolini M, Szabo IL, Zakany N, Olah A, Szollosi AG, Paus R, Biro T.	J Invest Dermatol	read the full story	hair follicle, ex vivo, organ culture, co-immunolabeling, G-protein, hair growth
2020	Toward predicting the spatio-temporal dynamics of alopecia areata lesions using partial differential equation analysis.	Atanaska Dobreva, Ralf Paus, N. G. Cogan	Bull Math Biol	read the full story	autoimmune disease, alopecia areata, partial differential equations, humanized mouse model
2020	Fluoxetine promotes human hair follicle pigmentation ex vivo: Serotonin re-uptake inhibition as a new anti-greying strategy?	Cheret J, Gherardini J, Bertolini M, Paus R.	Br J Dermatol	read the full story	hair follicle, ex vivo, organ culture, quantitative Masson-Fontana histomorphometry, serotonin receptor, melanotropic neurohormone
2020	Do hair follicles operate as primitive, multifocal kidney-like excretory (mini-)organs?	Carré JL, Suzuki T, Paus R	Exp Dermatol	read the full story	trichocytes, hair shafts, classical nephrological therapy, erythropoietin synthesis
2020	Neuroendocrinology and neurobiology of sebaceous gland.	Clayton RW, Langan EA, Ansell DM, de Vos IJHM, Göbel K, Schneider MR, Picardo M, Lim X, van Steensel MAM, Paus R	Biol Rev Camb Philos Soc	read the full story	nervous system, pituitary control, sebaceous glands, homeostasis
2020	Phytocannabinoid(-)-Cannabidiol operates as a complex, differential modular of human hair growth: Anti-inflammatory sub-micromolar versus hair growth inhibitory micromolar effects.	Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro T	J Invest Dermatol	read the full story	hair follicle, ex vivo organ culture, toll-like receptor, hair morphology
2020	Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata.	Laufer BR, Keren A, Paus R, Gilhar A.	Br J Dermatol	read the full story	hair loss, hair follicle, phosphodiesterase inhibitor, therapeutics
2020	Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during subtance P-mediated neurogenic inflammation ex vivo.	Gherardini J, Uchida Y, Hardman JA, Cheret J, Mace K, Bertolini M, Paus R	PLoS One	read the full story	macrophages, full-thickness skin organ culture, immunohistochemistry, neuroinflammatory stimulus
2020	Schwann cells as underestimated, major players in human skin physiology and pathology.	Bray ER, Cheret J, Yosipovitch G, Paus R.	Exp Dermatol	read the full story	axon regeneration, wound healing, atopic dermatitis, psoriasis
2020	Theophylline exerts complex anti-aging and anti-cytotoxicity effects in human skin ex vivo.	Bertolini M, Ramot Y, Gherardini J, Heinen G, Cheret J, Welss T, Giesen M, Funk W, Paus R.	Int J Cosmet Sci	read the full story	full thickness skin, organ culture, ex vivo, phosphodiesterase inhibitor, metallothionein‐1, collagen, skin‐protective properties
2019	JAK inhibitors and alopecia areata.	Gilhar A, Keren A, Paus R.	Lancet	read the full story	systemic therapy, cytokines, autoimmune disease
2019	Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine.	Gherardini J, Wegner J, Cheret J, Ghatak S, Lehmann J, Alam M, Jimenez F, Funk W, Bohm M, Botchkareva NV, Ward C, Paus R, Bertolini M.	Int J Cosmet Sci	read the full story	ex vivo, organ culture, UV exposure, keratinocyte apoptosis, photoprotectants, clinical relevance
2019	Nestin(+) progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo.	Liao T, Lehmann J, Sternstein S, Yay A, Zhang G, Matthiessen AE, Schumann S, Siemers F, Kruse C, Hundt JE, Langan EA, Tiede S, Paus R.	Arch Dermatol Res	read the full story	skin punch biopsies, ex vivo, wound healing model, pre-clinical, regenerative medicine, chronic skin ulceration
2019	Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle?	Nicu C, Hardman JA, Pople J, Paus R.	Exp Dermatol	read the full story	hair follicle, transmission electron microscopy, anagen‐catagen transition, lipogenesis, hair cycle
2019	Assessment of Quality of Life and Treatment Outcomes of Patients with persistent postchemotherapy alopecia.	Freites-Martinez A, Chan D, Sibaud V, Shapiro J, Fabbrocini G, Tosti A, Cho J, Goldfarb S, Modi S, Gajria D, Norton L, Paus R, Cigler T, Lacouture ME.	JAMA Dermatol	read the full story	persistent chemotherapy-induced alopecia, clinical study, hair loss, patinets, dermatologic therapy
2019	Hair growth control by innate immunocytes: Perifollicular macrophages revisited.	Muneeb F, Hardman JA, Paus R.	Exp Dermatol	read the full story	hair matrix, hair cycle stage, hair follicle morphogenesis, Wnt signalling, clinically relevant
2019	Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo.	Zhang GY, Langan EA, Meier NT, Funk W, Siemers F, Paus R.	PLoS One	read the full story	full thickness human skin, wound healing organ culture model, quantitative immunohistomorphometry, pre-clinical testing, keratin expression, energy metabolism
2019	Distinct patterns of hair graft Survival After Transplantation into 2 Nonhealing Ulcers: Is Location Everything?	Alam M, Cooley J, Plotczyk M, Martinez-Martin MS, Izeta A, Paus R, Jimenez F.	Dermatol Surg	read the full story	hair follicles, scar formation, hair growth, wound healing, human skin
2019	Image Gallery: Optical coherence tomography for intravital human hair follicle analyses ex vivo.	Lehmann J, Kemper B, Barroso Pena A, Schnekenburger J, Paus R, Bertolini M, Cheret J.	Br J Dermatol	read the full story	label‐free, high‐resolution, anatomical details, ex vivo, organ culture, hair matrix
2019	Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis.	Leon A, Rosen JD, Hashimoto T, Fostini AC, Paus R, Yosipovitch G.	Exp Dermatol	read the full story	hair follicle, mast cells, neurogenic inflammation, psoriatic scalp itch, immunogenic inflammation
2019	Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis.	Clayton RW, Gobel K, Niessen CM, Paus R, van Steensel MAM, Lim X.	Br J Dermatol	read the full story	genetic mouse models, mammalian skin, acne vulgaris, comedones, acne pathogenesis
2019	Hair disorders in patients with cancer.	Freites-Martinez A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME.	J Am Acad Dermatol	read the full story	chemotherapy induced alopecia, hair repigmentation, immunotherapies, oncology patients
2019	Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias.	Harries M, Imanishi H, Paus R.	J Am Acad Dermatol	read the full story	laser capture microdissection, microarray analysis, hair follicle, immune privilege collapse, follicular inflammation
2019	TRPV4 is expressed in human hair follicles and inhibits hair growth in vitro.	Szabo IL, Herczeg-Lisztes E, Szegedi A, Nemes B, Paus R, Biro T, Szollosi AG.	J Invest Dermatol	read the full story	calcium permeable, microflorimetric Ca2+ measurement, outer root sheath keratinocytes, peripheral sensory nerves
2019	Growth hormone operates as a neuroendocrine regulator of human hair growth ex vivo.	Alam M, Below DA, Cheret J, Langan EA, Bertolini M, Jimenez F, Paus R.	J Invest Dermatol	read the full story	human hair follicle, ex vivo, organ culture, mini-organ, neuropeptides, pigmentation
2019	Alopecia areata patients show deficiency of FOXP3+CD39+ T regulartory cells and clonotypic restriction of Treg TCRß-chain, which highlights the immunopathological aspect of disease.	Hamed FN, Astrand A, Bertolini M, Rossi A, Maleki Dizaji A, Messanger AG, Mc Donagh AJG, Tazi-Ahnini R.	PloS One	read the full story	flow cytometry, next Generation Sequencing, hair loss, Treg clonotypes, autoimmune reaction
2019	Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation.	Hawkshaw NJ, Hardman JA, Alam M, Jimenez F, Paus R.	Br J Dermatol	read the full story	in situ hybridization, human telogen, scalp hair follicle sections, hair biology
2019	Inhibition of ATP binding cassette transporter B1 sensitizes human hair follicles to chemotherapy-induced damage.	Smart E, Farjo N, Farjo B, Haslam IS, Paus R.	J Dermatol Sci	read the full story	quantitative immunohistomorphometry, 4-hydroxycyclophosphamide, anthracycline doxorubicin, ex vivo, proliferation, apoptosis
2019	The Phytocannabinoid (-)-Cannabidiol operates as a complex, differential modulator of human hair qrowth: anti-inflammatory submicromolar versus hair growth inhibitory micromolar effects.	Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro T.	J Invest Dermatol	read the full story	hair follicle, organ culture, hair shaft, hair cycle, hair matrix keratinocytes
2019	Seborrheic dermatitis-Looking beyond Malassezia.	Wikramanayake TC, Borda LJ, Miteva M, Paus R.	Exp Dermatol	read the full story	chronic, relapsing inflammatory, skin disease, Mpzl3 knockout mice, epidermal barrier, sebaceous activity
2019	CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia.	Purba TS, Ng'andu K, Brunken L, Smart E, Mitchell E, Hassan N, O'Brien A, Mellor C, Jackson J, Shahmalak A, Paus R.	EMBO Mol Med	read the full story	hair follicle, organ culture, epithelial bulge stem cell analysis, chemotherapy, paclitaxel, docetaxel, mitotic defects
2019	PPAR-Y signalling as a key mediator of human hair follicle physiology and pathology.	Ramot Y, Bertolini M, Bobolijava M, Uchida Y, Paus R.	Exp. Dermatol	read the full story	hair follicle development, scarring alopecia, epithelial-mesenchymal transition, androgenetic alopecia
2019	Precilinal evidence that PPARγ- modulator, N-Acetyl-GED-0507-34-Levo, may protect human hair follicle epithelial stem cells against lichen planopilaris -associated damage.	Cheret J, Piccini I, Hardman-Smart J, Ghatak S, Alam M, Lehmann J, Jimenez F, Erdmann H, Poblet E, Botchkareva N, Paus R, Bertolini M.	J Eur Acad Dermatol Vernereol	read the full story	hair follicle, ex vivo, organ culture, immunohistochemistry, NAGED, hair loss, lichen planopilaris
2019	Mineralocorticoid receptor antagonists stimulate human hair growth ex vivo.	Hundt JE, Sass S, Funk W, Biro T, Farman N, Langan EA, Paus R.	Skin Pharmacol Physiol	read the full story	hair follicle, ex vivo, organ culture, glucocorticoid, hair cycle
2019	Y-27632 preserves epidermal intregity in a human skin-organ culture (h-SOC) system by regulating AKT and ERK signalling pathways.	Zang X, Qin J, Xie Z, Liu C, Su Y, Chen Z, Zho Q, Ma C, Liu G, Paus R, Guo J, Wu X.	J Dermatol Sci	read the full story	human breast skin, organ culture, ex vivo, epidermal cell proliferation, immunofluorescence staining, ROCK inhibitor, epidermal architecture
2019	Frontiers in alopecia areata pathobiology research.	Gilhar A, Britva RL, Keren A, Paus R.	J Allergy Clin Immunol	read the full story	humanized mouse model, autoantigens, regulatory T cells, immune privilege
2019	Human perifollicular macrophages undergo apoptosis, express Wnt ligands and switch their polarization during catagen.	Hardman JA, Muneeb F, Pople J, Bhogal R, Shahmalak A, Paus R.	J Invest Dermatol	read the full story	human hair follicle, ex vivo, organ culture, hair cycle, inflammatory hair disease
2019	Model-based approach to the design of pharmaceutical roller-compaction processes.	Toson P, Lopes DG, Paus R, Kumar A, Geens J, Stibale S, Quodbach J, Kleinebudde P, Hsiao WK, Khinast J.	Int J Pharm	read the full story	mathematical model, in-silico, ibuprofen formulations, iterative calibration
2018	Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-alpha administration differ during wound repair and regeneration.	Abarca-Buis RF, Martinez-Jimenez A, Vera-Gomez E, Contreras-Figueroa ME, Garciadiego-Cazares D, Paus R, Robles-Tenorio A, Krotzsch E.	Differentiation	read the full story	ear punch wound mouse model, histology analysis, fibrotic scarring, epidermal apoptosis
2018	Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management.	Paus R, Bulfone-Paus S, Bertolini M.	J Investig Dermatol Symp Proc	read the full story	hair bulb, pharmacological manipulation, Immune privilege collapse-related autoimmune diseases
2018	An efficient method for eccrine gland isolation from human scalp.	Jimenez F, Alam M, Hernandez I, Poblet E, Hardman JA, Paus R.	Exp Dermatol	read the full story	hair graft harvesting method, calp follicular unit grafts, microdissection, methylene blue staining
2018	NF-kappaB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types.	Krieger K, Millar SE, Mikuda N, Krahn I, Kloepper JE, Bertolini M, Scheidereit C, Paus R, Schmidt-Ullrich R.	J Invest Dermatol	read the full story	humanized mouse model, hair cycle analysis, histological techniques, anagen induction, telogen−anagen transition
2018	Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue.	Poblet E, Jimenez F, Escario-Travesedo E, Hardman JA, Hernandez-Hernandez I, Agudo-Mena JL, Cabrera-Galvan JJ, Nicu C, Paus R.	Br J Dermatol	read the full story	3D reconstruction, human scalp, follicular unit transplant grafts, scalp strip ex vivo, human skin adnexa
2018	Epithelial-to-mesenchymal stem cell transition in a human organ: Lessons from lichen planopilaris.	Imanishi H, Ansell DM, Cheret J, Harries M, Bertolini M, Sepp N, Biro T, Poblet E, Jimenez F, Hardman J, Panicker SP, Ward CM, Paus R.	J Invest Dermatol	read the full story	hair follicle, ex vivo organ culture, immunohistochemistry, transmission electron microscopy, preclinical assay
2018	Prolactin as a candidate sebotrop(h)ic hormone?	Langan EA, Hinde E, Paus R.	Exp Dermatol	read the full story	human dermatoses, sebaceous gland, therapeutic strategies, cutaneous ageing
2018	A guide to studying human dermal adipocytes in situ.	Nicu, C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R.	Exp Dermatol	read the full story	quantitative immunohistomorphometry, dermal white adipose tissue, in situ hybridization, neuroendocrinology
2018	Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture.	Parodi C, Hardman JA, Allavena G, Marotta R, Catelani T, Bertolini M, Paus R, Grimaldi B.	PLoS Biol	read the full story	cell culture, quantitative immunohistomorphometry, ex vivo, knockdown, preclinical research model
2018	Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg total deletion.	Sardella C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F.	J Invest Dermatol	read the full story	humanized mouse model, skin grafts, in vivo, gene expression, adipose tissue-mediated signals
2018	Melatonin: A cutaneous perspective on its production, metabolism, and functions.	Slominski AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ, Paus R.	J Invest Dermatol	read the full story	hair follicle, photo-protection, anti-cancer activity, wound healing, pigmentation, inflammatory dermatoses
2018	Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal.	Foster AR, Nicu C, Schneider MR, Hinde E, Paus R.	Arch Dermatol Res	read the full story	in vivo BODIPY, immunohistomorphometry, wound healing, adipocyte hypertrophy
2018	Lichen planopilaris and frontal fibrosing alopecia as model epithelial stem cell diseases.	Harries MJ, Jimenez F, Izeta A, Hardman J, Panicker SP, Poblet E, Paus R.	Trends Mol Med	read the full story	hair follicle, PPAR-γ, epithelial-mesenchymal transition, immune-privilege
2018	Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles.	Hawkshaw NJ, Hardman JA, Haslam IS, Shahmalak A, Gilhar A, Lim X, Paus R.	PLoS Biol	read the full story	hair follicle, ex vivo organ culture, Quantitative immunohistomorphometry, bioinformatics, immunosuppressant, therapeutic strategy
2018	How UV light touches the brain and endocrine system through skin, and why.	Slominski AT, Zmijewski MA, Plonka PM, Szaflarski JP, Paus R.	Endocrinology	read the full story	environmental factors, UV radiation, body homeostasis, neuro-endocrine system
2018	Image Gallery: Intravital visualization of the dynamic changes in human hair follicle cycling.	Alam M, Hernandez I, Paus R, Jimenez F.	Br J Dermatol	read the full story	anagen, catagen, telogen, methylene blue staining, hair cycle stage
2018	Topically applied nicotinamide inhibits human hair follicle growth ex vivo.	Haslam IS, Hardman JA, Paus R.	J Invest Dermatol	read the full story	organ culture, microdissected human scalp hair follicles, hair growth inhibitor, catagen, mast cells
2018	Re-investigating the basement membrane zone of psoriatic epidermal lesions: Is laminin-511 a new player in psoriasis pathogenesis?	Natsumi A, Sugawara K, Yasumizu M, Mizukami Y, Sano S, Morita A, Paus R, Tsuruta D.	J Histochem Cytochem	read the full story	skin tumorectomy, immunohistochemistry, transmission electron microscopy, laminin-511, keratinocyte growth/death
2018	Cover Image: Neuroendocrine treatment of inherited keratin disorders by cannabinoids?	Ramot Y, Olah A, Paus R.	Br J Dermatol	read the full story	uman skin organ culture, ex vivo, epidermolytic ichthyosis, keratin disorders, cannabinoid signalling
2018	iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata.	Ghraieb A, Keren A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A.	J Autoimmun	read the full story	humanized mouse model, xenotransplants, lymphocytes, therapeutic potential
2018	Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin.	Keren A, Shemer A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A.	J Allergy Clin Immunol	read the full story	humanized mouse model, sublethal irradiation, immunohistochemical analysis, cytokine analyses, psoriatic lesions
2018	Peroxisome Proliferator-Activated Receptor-gamma-Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium.	Ramot Y, Alam M, Olah A, Biro T, Ponce L, Cheret J, Bertolini M, Paus R.	J Invest Dermatol	read the full story	ex vivo organ culture, gene expression, N-Acetyl-GED, mitochondrial function, ORS keratinocytes
2018	Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling.	Dobreva, A, Paus R, Cogan NG.	Math Med Biol	read the full story	mathematical modelling, anagen phase interruption, therapeutic targets
2018	Visualization of global RNA synthesis in a human (mini-) organ in situ by click chemistry.	Purba TS, Marsh J, Ng'andu K, Kurinna S, Paus R.	Biotechniques	read the full story	human hair follicle, ex vivo organ culture, in situ RNA synthesis, 5-ethynyl uridine
2018	Bridging the "Dead hair"-"live follicle" divide in applied hair research.	Bertolini M, Botchkareva N, Westgate G, Ward C, Cornwell P, Paus R.	J Cosmet Sci	read the full story	synopsis, mini-organ, hair shaft structure
2018	Olfactory receptor OR2AT4 regulates human hair growth.	Cheret J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M, Hatt H, Paus R.	Nat Commun	read the full story	ex vivo, organ culture, knockdown, histological analysis, genome-micro array analysis, sandalore, synthetic sandalwood, hair growth, hair loss therapy
2018	A technique for more precise distinction between catagen and telogen human hair follicles ex vivo.	Hernandez I, Alam M, Platt C, Hardman J, Smart E, Poblet E, Bertolini M, Paus R, Jimenez F.	J Am Acad Dermatol	read the full story	ex vivo organ culture, hair cycle stage, macroscopic analysis
2018	Transcriptional programming of normal and inflamed human epidermis at single-cell resolution.	Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ.	Cell Rep	read the full story	computational analysis, single-cell RNAseq, keratinocyte
2018	Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P-induced human mast cell activation and degranulation in the hair follicle.	Jadkauskaite L, Bahri R, Farjo N, Farjo B, Jenkins G, Bhogal R, Haslam I, Bulfone-Paus S, Paus R.	J Allergy Clin Immunol	read the full story	ex vivo organ culture, immunohistochemistry, mast cells degranulation and activity assay, neuropeptide, androgenetic alopecia, alopecia areata
2018	Bi-allelic mutations in LSS, encoding lanosterol synthase, cause autosomal-recessive hypotrichosis simplex.	Romano, MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmuller J, Nurnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lutjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC.	Am J Hum Genet	read the full story	whole-exsome sequencing, alopecia, cholesterol biosynthetic pathway, lanosterol synthase
2018	The renaissance of human skin organ culture: A critical reappraisal.	Zhou L, Zhang X, Paus R, Lu Z.	Differentiation	read the full story	ex vivo, morphological analyses, gene silencing, assays
2018	Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding?	Langan EA, Fink T, Paus R.	Arch Dermatol Res	read the full story	ex vivo, human skin organ culture, PRL receptor antagonists, keratinocyte differentiation
2018	Retinoic acid co-treatment aggravates severity of dioxin-induced skin lesions in hairless mice via induction of inflammatory response.	Rudyak SG, Usakin LA, Tverye EA, Orekhov AS, Belushkina NN, Paus R, Paltsev MA, Panteleyev AA.	Biochem Biophys Res Commun	read the full story	humanized mouse model, halogenated polyaromatic hydrocarbons, skin pathologies, keratinocyte
2017	Oxidative damage control in a human (mini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition.	Haslam IS, Jadkauskaite L, Szabo IL, Staege S, Hesebeck-Brinckmann J, Jenkins G, Bhogal RK, Lim FL, Farjo N, Farjo B, Biro T, Schafer M, Paus R.	J Invest Dermatol	read the full story	human hair follicle, organ culture, ex vivo, quantitative immunofluorescence, ROS, keratinocytes
2017	Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.	Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nothen MM.	Nat Commun	read the full story	geno-wide analysis, meta-analysis, hair follicle cycling, therapeutics
2017	Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology.	Jumper N, Hodgkinson T, Paus R, Bayat A.	PLoS One	read the full story	site-specific in situ microdissection, transcriptome array analysis, 2D cell culture, TGFβ-mediated signaling
2017	Enhanced neurogenic biomarker expression and reinnervation in human acute skin wounds treated by electrical stimulation.	Sebastian A, Volk SW, Halai P, Colthurst J, Paus R, Bayat A.	J Invest Dermatol	read the full story	Human punch biopsy, wound healing, microarray analysis, in vivo repair, neuroblastoma
2017	Cover Image: Are melanocyte-associated peptides the elusive autoantigens in alopecia areata?	Bertolini M, Rossi A, Paus R.	Br J Dermatol	read the full story	hair follicle, hair matrix melanocytes, mast cells, autoantigens, melanogenesis
2017	Regulatory T cells in skin facilitate epithelial stem cell differentiation.	Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD.	Cell	read the full story	immune-profiling, immunofluorescent microscopy, in vivo mouse model, skin inflammation, telogen-anagen transition, Jagged 1, hair regeneration, alopecia areata
2017	Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1beta-mediated signaling.	Stojadinovic O, Wikramanayake TC, Villasante Fricke AC, Yin NC, Liang L, Hinde E, Escandon J, Tomic-Canic M, Ansell DM, Paus R, Jimenez JJ.	Heliyon	read the full story	Keywords: incisional wound induction, histological analysis, cytokine injection, Gene expression profiling, hair cycle, IL-1β signaling
2017	Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.	Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmuller J, Stander S, Luger T, Paus R, Cheret J, Hatt H.	Exp Dermatol	read the full story	human keratinocytes culture, cAMP‐dependent pathway, skin diseases, wound repair
2017	Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?	Jadkauskaite L, Coulombe PA, Schafer M, Dinkova-Kostova AT, Paus R, Haslam IS.	Bioessays	read the full story	redox homeostasis, NRF2 activation, hair follicle pathologies
2017	E-cadherin-mediated cell contact controls the epidermal damage response in radiation dermatitis.	Xie G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H, Ramot Y, Paus R, Yue Z.	J Invest Dermatol	read the full story	human skin biopsy, footpad mouse model, in vivo rescue, epidermal keratinocytes, radiotherapy
2017	Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix.	Purba TS, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, Ceballos L, Gandarillas A, Paus R	Eur J Cell Biol	read the full story	human hair follicle, ex vivo organ culture, in situ hybridisation, CIP/KIP proteins, hair bulb growth
2017	T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle.	Oelert T, Gilhar A, Paus R.	Exp Dermatol	read the full story	hair follicle, immune privilege collapse, CD4+ regulatory T cells, alopecia areata
2017	A role for neuregulin-1 in promoting keloid fibroblast migration via ErbB2-mediated signaling.	Jumper N, Hodgkinson T, Paus R, Bayat A.	Acta Derm Venereol	read the full story	laser capture microdissection, in situ gene expression profiling, NRG1/ErbB2/Src/PTK2 signaling pathway, fibroproliferative tumour
2017	Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2.	Purba TS, Peake M, Farjo B, Farjo N, Bhogal RK, Jenkins G, Paus R.	Sci Rep	read the full story	ex vivo, hair follicle organ culture, Immunofluorescence, Quantitative immunohistomorphometry, epithelial stem cells
2016	Hair follicle bulge stem cells appear dispensable for the acute phase of wound re-epithelialization.	Garcin CL, Ansell DM, Headon DJ, Paus R, Hardman MJ.	Stem Cells	read the full story	wound healing, transgenic mice, in vivo
2016	An innovative approach to dissecting keloid disease leading to identification of the retinoic acid pathway as a potential therapeutic target.	Jumper N, Paus R, Bayat A.	Plast Reconstr Surg Glob Open	read the full story	skin biopsies, laser capture microdissection, epidermis
2016	A Guide to studying human hair follicle cycling in vivo.	Oh JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS, Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV.	J Invest Dermatol	read the full story	pre-clinical, xenograft, immuno-histochemistry
2016	Lhx2 is a direct NF-kappaB target gene that promotes primary hair follicle placode down-growth.	Tomann P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R.	Development	read the full story	gene expression, transcriptome, embryos, cell migration
2016	Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice.	Dahlhoff M, Camera E, Schafer M, Emrich D, Riethmacher D, Foster A, Paus R, Schneider MR.	Development	read the full story	gene targeting, mouse line, in vivo, meibomian gland disease
2016	p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a rat model of radiation dermatitis.	Liao C, Xie G, Zhu L, Chen X, Li X, Lu H, Xu B, Ramot Y, Paus R, Yue Z.	J Invest Dermatol	read the full story	chip analysis, in vivo, therapeutic targeting, dermatoses
2016	Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse.	Bertolini M, Pretzlaff M, Sulk M, Bahr M, Gherardini J, Uchida Y, Reibelt M, Kinori M, Rossi A, Biro T, Paus R.	Br J Dermatol	read the full story	hair follicle organ culture, immuno‐histomorphometry, autoimmune disorder
2016	A primer for studying cell cycle dynamics of the human hair follicle.	Purba TS, Brunken L, Hawkshaw NJ, Peake M, Hardman J, Paus R.	Exp Dermatol	read the full story	immuno-labelling, cell cycle, proliferation, apoptosis
2016	Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue.	Bagabir RA, Syed F, Shenjere P, Paus R, Bayat A.	J Invest Dermatol	read the full story	molecular diagnostic, biomarker, immunohistochemistry, dermal scarring
2016	Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.	Gilhar A, Schrum AG, Etzioni A, Waldmann H, Paus R.	Autoimmun Rev	read the full story	xenografts, transplantation, SCID mice, therapeutic strategies
2016	The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease.	Jumper N, Hodgkinson T, Arscott G, Har-Shai Y, Paus R, Bayat A.	J Invest Dermatol	read the full story	laser capture microdissection, microarray, luciferase assay, metabolism
2016	The gut-skin axis in health and disease: A paradigm with therapeutic implications.	O'Neill CA, Monteleone G, McLaughlin JT, Paus R.	Bioessays	read the full story	microbiota, signaling pathways, skin co‐morbidities
2016	The thyroid hormone analogue KB2115 (Eprotirome) prolongs human hair growth (anagen) ex vivo.	Olah A, Gherardini J, Bertolini M, Cheret J, Ponce L, Kloepper J, Biro T, Soeberdt M, Abels C, Paus R.	J Invest Dermatol	read the full story	human scalp hair follicle, organ culture, hair cycle, translational human hair research
2016	Exploring the "brain-skin connection": Leads and lessons from the hair follicle.	Paus R.	Curr Res Transl Med	read the full story	human hair follicle, organ culture, neuro-hormone, skin epithelium, Melatonin
2016	Biology of the eyelash hair follicle: an enigma in plain sight.	Paus R, Burgoa I, Platt CI, Griffiths T, Poblet E, Izeta A.	Br J Dermatol	read the full story	mini-organ culture, greying, cosmetic manipulation
2016	Mutations in TSPEAR, encoding a regulator of notch signaling, affect tooth and hair follicle morphogenesis.	Peled A, Sarig O, Samuelov L, Bertolini M, Ziv L, Weissglas-Volkov D, Eskin-Schwartz M, Adase CA, Malchin N, Bochner R, Fainberg G, Goldberg I, Sugawara K, Baniel A, Tsuruta D, Luxenburg C, Adir N, Duverger O, Morasso M, Shalev S, Gallo RL, Shomron N, Paus R, Sprecher E.	PLoS Genet	read the full story	siRNA, NOTCH1 reporter assay, knockdown in mice hair follicles, organ cultures, apoptosis, ectodermal dysplasias
2016	Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit?	Poblet E, Jimenez-Acosta F, Hardman JA, Escario E, Paus R.	Exp Dermatol	read the full story	3D imaging, scalp follicular units, skin appendages
2016	Thyroid hormones enhance mitochondrial function in human epidermis.	Vidali S, Cheret J, Giesen M, Haeger S, Alam M, Watson REB, Langton AK, Klinger M, Knuever J, Funk W, Kofler B, Paus R.	J Invest Dermatol	read the full story	Human skin organ culture, ex vivo, immunohistochemistry, Transmission electron microscopy, In situ zymography, skin aging, mitochondrial function
2016	Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis.	Fleger-Weckmann A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R.	Matrix Biol	read the full story	Hair follicle formation, histological analysis, electron microscopy, mouse model, hair shaft differentiation, basement membrane