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2023Preliminary evidence that Merkel cells exert chemosensory functions in human epidermisPiccini I, Chéret J, Tsutsumi M, Sakaguchi S; Ponce L, Almeida, L, Funk W, Kückelhaus M; Kajiya K, Paus R, Bertolini MExp Dermatolread the full storyMerkel cell, Chemosensation, Olfactory receptor, Vesicle release
2023mTORC1 activity negatively regulates human hair follicle growth and pigmentationSuzuki T, Chéret J, Dinelli Scala F, Akhundlu A, Gherardini J, Demetrius D, O'Sullivan JDB, Kuka Epstein G, Bauman AJ, Demetriades C, Paus REMBO Reportsread the full storyCanities, Hair follicle pigmentation, Hair follicle organ culture, Melanogenesis, mTORC1 signaling
2023Differential regulation of IL-17A and IL-17F via STAT5 contributes to psoriatic diseaseCole S, Manghera A, Burns L, Barrett J, Yager N, Rhys H, Skelton A, Cole J, Goodyear CS, Griffiths M, Baeten M, Bertolini M, Shaw S, Al-Mossawi H, Maroof AJournal of Allergy and Clinical Immunologyread the full storyPsoriasis, IL-17 signaling, STAT signaling, lesional skin organ culture, scRNAseq
2023Laser capture microdissection as a method for investigating the human hair follicle microbiome reveals region-specific differences in the bacteriome profileLousada MB, Edelkamp J, Lachnit T, Fehrholz M, Jimenez F, Paus RBMC Research Notesread the full storyHair follicle organ culture, Microbiome, Laser-Capture Microdissection
2023Involvement of ILC1-like innate lymphocytes in human autoimmunity: lessons from alopecia areataLaufer Britva R, Keren A, Bertolini M, Ullmann Y, Paus R, Gilhar AeLiferead the full storyAlopecia Areata, Hair Loss, Hair growth, Humanized mouse model, innate lymphoid cells-type 1
2023Application of topical Sandalore® increases epidermal dermcidin synthesis in organ-cultured human skin ex vivoEdelkamp J, Lousada MB, Pinto D, Chéret J, O'Sullivan JDB, Biundo A, Jimenez F, Funk W, Roessing C, Rippmann V, Paus R, Bertolini MSkin Pharmacol. Physiol.read the full storySkin organ culture, Chemosensation, Olfactory Receptors, Microbiome, Antimicrobial peptides
2023Concentration-dependent stimulation of melanin production as well as melanocyte and keratinocyte proliferation by melatonin in human eyelid epidermisSevilla A, Chéret J, Lee W, Paus RExp. Dermatol.read the full storyFull-thickness eyelid skin organ culture, melatonin, melanogenesis,
2023Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplantsKeren A, Reich K, Bertolini M, Moga A, Riethmüller C, Ullmann Y, Paus R, Gilhar AAllergyread the full storyAtopic Dermatitis; humanized mouse model; xenotransplants; skin barrier deficits
2022Human Hair Follicles Operate a Functional Peripheral Equivalent of the Hypothalamic-Pituitary-Somatotropic Axis Ex VivoHoresh EJ, Gherardini J, Alam M, Rodriguez-Feliz J, Bauman AJ, Chéret J, Paus RJIDread the full storyHF organ culture ex vivo; HPS-Axis; brain-HF-axis; neuroendocrinology
2022Downregulation of pathogenic MICA-NKG2D interactions as a novel strategy in alopecia areata management: a new rationale for adjunct statin therapy?Gherardini J, Rivas KE, Chéret J, Strbo N, Paus RJEADVread the full storyOuter Root Sheath Keratinocytes; in vitro models, Alopecia Areata; IP collapse
2022Mitochondrially Localized MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte ProliferationWikramanayake TC, Nicu C, Gherardini J, Mello ACGCV, Chéret J, Paus RJIDread the full storySebaceous gland function, MPZL3
2022The impact of perceived stress on the hair follicle: Towards solving a psychoneuroendocrine and neuroimmunological puzzleO'Sullivan JDB , Peters EMJ, Amer Y, Atuluru P, Chéret J, Rosenberg AM, Picard M, Paus RFront Neuroendocrinol.read the full storybrain-HF axis; perceived stress in hair greying and hair loss, neuroendocrinology
2022Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactionsPlatt CI, Cheret J, Paus RArch Dermatol Res.read the full storyOrganotypic model, 3D dermal papilla spheroids, Epithelial mesenchymal interaction, hair matrix
2022A plaidoyer for the use of human skin xenotransplant mouse models in preclinical psoriasis researchGilhar A, Reich K, Keren A, Paus RJ Eur Acad Dermatol Venereol.read the full storyPsoriasis, humanized mouse model, xenotransplantation
2022Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic PhenotypePiccini I, Sousa M, Altendorf S, Jimenez F, Rossi A, Funk W, Biró T, Paus R, Seibel J, Jakobs M, Yesilkaya T, Edelkamp J, Bertolini MNutrients.read the full storyFemale pattern hair loss, hair follicle, metabolism, nutrient supplementation
2022Circadian rhythms in psoriasis and the potential of chronotherapy in psoriasis managementLuengas-Martinez A, Paus R, Iqbal M, Bailey L, Ray DW, Young HSExp. Dermatolread the full storyVEGF-A, chronotherapy, circadian rhythms, psoriasis.
2022Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational HorizonsSenna MM, Peterson E, Jozic I, Chéret J, Paus RJID Innov.read the full story5α-reductase inhibitor, alopecia areata, androgenetic alopecia, corticotropin-releasing hormone, epithelial‒mesenchymal transition, frontal fibrosing alopecia, hair follicle, immune privilege, keratin, keratinocyte, lichen planopilaris, macrophage, major histocompatibility complex, primary cicatricial alopecia, personal care product, peroxisome proliferator–activated receptor-γ, stem cell, substance P, epithelial hair follicle stem cell, α-melanocyte-stimulating hormone
2022Hydra and the hair follicle - An unconventional comparative biology approach to exploring the human holobiontLousada MB, Lachnit T, Edelkamp J, Paus R, Bosch TCGBioessays.read the full storyAntimicrobial peptides, microbial ecology, microbiome, model organisms
2022Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin agingWikramanayake TC, Chéret J, Sevilla A, Birch-Machin M, Paus RExpert opinion on Therapeutic Targetsread the full storyReactive oxygen species (ROS), alopecia, appendage, epidermis, hair follicle, mitochondria, myelin protein zero-like 3 (MPZL3), sebaceous gland, skin cancer
2022Revisiting the role of melatonin in human melanocyte physiology: A skin context perspectiveSevilla A, Chéret J, Slominski RM, Slominski AT, Paus RJ. Pineal resread the full storyHair follicle, human skin, melanocyte, melatonin, pigmentation
2022An extract of Leontopodium alpinum inhibits catagen development ex vivo and increases hair density in vivoCampiche R, Le Riche A, Edelkamp J, Fernandez Botello A, Martin E, Gempeler M, Bertolini MInt J Cosmet Sci.read the full storyLeontopodium alpinum, anagen phase, anti-hair loss, hair follicle, hair growth, versican
2022Human organ reju-venation by VEGF-A: Lessons from the skinKeren A, Bertolini M, Yaniv K, Ullmann Y, Paus R, Gilhar ASci. Advancesread the full storyVEGF-A, skin aging, skin rejuvenation, humanized mouse model, skin organ culture ex vivo
2022Effect of minoxidil formulations on human scalp skin xenotransplants on SCID mice: A novel pre-clinical in vivo assay for androgenetic alopecia researchGilhar A, Keren A, Ullmann Y, Wu J, Paus RExp Dermatol.read the full storyMouse model, xenotransplant, preclinical model, hair growth, hair loss, androgenetic alopecia
2022Growth Hormone and the Human Hair FollicleHoresh E.J, Chéret J, Paus RInt J Mol Sci.read the full storyGrowth hormone, neuroendocrine, hair follicle, hair growth
2021The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendagesYue ZC, Lei MX, Paus R, Chuong CMBiol Rev Camb Philos Soc.read the full storyVGEF, psoriasis, therapeutic strategies
2021Adiponectin negatively regulates pigmentation, Wnt/β-catenin and HGF/c-Met signalling within human scalp hair follicles ex vivoNicu C, Jackson J, Shahmalak A, Pople J, Ansell D, Paus RArch Dermatol Res.read the full storyhair follicle, adiponectin, pigmentation, hair follicle organ culture, ex vivo, dermal papilla, WNT
2021Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldnessHochfeld L.M, Bertolini M, Broadley D, Botchkareva N.V, Betz R.C, Schoch S, Nöthen M.M, Heilmann-Heimbach S.PLoS One.read the full storyhair follicle, male pattern hair loss, WNT, genetic
2021Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylaseFiglak k, Williams G, Bertolini M, Paus R, Philpott M.P.Sci Rep.read the full storyhair follicle, metabolism, outer root sheath keratinocytes, hair follicle organ culture, ex vivo
2021Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicleUchida Y, Gherardini J, Pappelbaum K, Chéret J, Schulte-Mecklenbeck A, Gross CC, Strbo N, Gilhar A, Rossi A, Funk W, Kanekura T, Almeida L, Bertolini M, Paus R.J Autoimmun.read the full storyalopecia areata, autoimmunity, resident human γδT-cells, hair follicle, MICA, NKG2D, stress, ex vivo model
2021The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targetsSuzuki T, Ito T, Gilhar A, Tokura Y, Reich K, Paus R.Exp Dermatol.read the full storyhair growth, skin, psoriasis, hair follicle
2021PPARγ signaling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transitionPiccini I, Brunken L, Chéret J, Ghatak S, Ramot Y, Alam M, Purba TS, Hardman J, Erdmann H, Jimenez F, Paus R, Bertolini M.Br J Dermatol.read the full storyalopecia, chemotherapy, treatment, prevention, PPARγ agonist
2021Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology.Wikramanayake TC, Nicu C, Chéret J, Czyzyk TA, Paus R.Bioessays.read the full storyMyelin Protein Zero-like 3, CLOCK, PPARγ, mitochondria
2021A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism?Limbu SL, Purba TS, Harries M, Wikramanayake TC, Miteva M, Bhogal RK, O'Neill CA, Paus R.Bioessays.read the full storydandruff, scalp, hair follicle, cosmeceuticals
2021Quantitative mapping of human hair greying and reversal in relation to life stressRosenberg AM, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Kumar Soni R, Lacefield C, Tobin DJ, Paus R, Picard M.Elife.read the full storystress, premature greying, hair shaft proteomics
2021A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?Ivan Jozic, Jérémy Chéret, Beatriz Abdo Abujamra, Mariya Miteva, Jennifer Gherardini, Ralf PausBiomedicinesread the full storycaveolin-1, scarring alopecia, hair follicle stem cells, immune privilege collapse
2021Sensory re-innervation of human skin by human neural stem cell-derived peripheral neurons ex vivoChéret J, Piccini I, Gherardini J, Ponce L, Bertolini M, Paus R.J Invest Dermatol.read the full storyskin explants, re-innervation, iPS cells
2021Transduction-induced overexpression of Merkel cell T antigens in human hair follicles induces formation of pathological cell clusters with Merkel cell carcinoma-like phenotypeThibault Kervarrec, Jérémy Chéret, Ralf Paus, Roland Houben, David SchramaExp Dermatol.read the full storyMerkel cells, carcinoma, polyomavirus, hair follicle, malignant transformation, tumor
2021Can antibiotic-induced changes in the composition of the hair follicle microbiome regulate human hair growth?Bispo Lousada M, Edelkamp J, Lachnit T, Erdmann H, Paus RExp Dermatol.read the full storymicrobiome, hair growth, hair follicle
2021UDP-GlcNAc-1-phosphotransferase is a clinically important regulator of human and mouse hair pigmentationTiede S, Hundt JE, Paus RJ Invest Dermatol.read the full storyhair follicle, pigmentation, therapeutics, greying
2021Quantitative mapping of human hair greying and reversal in relation to life stressRosenberg AM, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Kumar Soni R, Lacefield C, Tobin DJ, Paus R, Picard MElife.read the full storyhair follicle, greying, pigmentation, stress
2021Sensory re-innervation of human skin by human neural stem cell-derived peripheral neurons ex vivoChéret J, Piccini I, Gherardini J, Ponce L, Bertolini M, Paus RJ Invest Dermatol.read the full storymodel, skin re-innervation, itch irritation
2021A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?Jozic I, Chéret J, Abujamra BA, Miteva M, Gherardini J, Paus RBiomedicines.read the full storyhair follicle, alopecia target, frontal fibrosing alopecia
2021Pathobiology questions raised by telogen effluvium and trichodynia in COVID-19 patientsDi Landro A, Naldi L, Glaser E, Paus R, Tosti AExp Dermatol. read the full storyContinuous Positive Airway Pressure, paracetamol, systemic steroids, anticoagulants, clinical manifestations
2021Stress and Nasal Allergy: Corticotropin-Releasing Hormone Stimulates Mast Cell Degranulation and Proliferation in Human Nasal MucosaYamanaka-Takaichi M, Mizukami Y, Sugawara K, Sunami K, Teranishi Y, Kira Y, Paus R, Tsuruta DInt J Mol Sci.read the full storyinflammation, stem cell factor, antalarmin, therapeutics
2021Hair follicle chemosensation: TRPM5 signalling is required for anagen maintenanceMardaryev A, van Lessen M, Alam M, Acosta FJ, Bíró T, Paus RJ Invest Dermatol.read the full storyhair cycle, hair follicle, triphenylphosphine oxide, TRPM5
2021Beyond the NFAT Horizon: From Cyclosporine A-Induced Adverse Skin Effects to Novel TherapeuticsHawkshaw NJ, Paus RTrends Pharmacol Sci.read the full storyhypertrichosis, human model systems, immunosuppressive therapy
2021The biology of human hair greyingO'Sullivan JDB, Nicu C, Picard M, Chéret J, Bedogni B, Tobin DJ, Paus RBiol Rev Camb Philos Soc.read the full storymelanogenesis, bulge melanocyte stem cells, pigmentation, HFPU melanocyte survival
2021Inhibition of Shh Signaling through MAPK Activation Controls Chemotherapy-Induced AlopeciaHaslam IS, Zhou G, Xie G, Teng X, Ao X, Yan Z, Smart E, Rutkowski D, Wierzbicka J, Zhou Y, Huang Z, Zhang Y, Farjo N, Farjo B, Paus R, Yue ZJ Invest Dermatol.read the full storyantimitotic, apoptosis-promoting, MAPK-Shh axis
2021Compartmentalised metabolic programmes in human anagen hair follicles: New targets to modulate epithelial stem cell behaviour, keratinocyte proliferation and hair follicle immune status?Purba TS, Berriche L, Paus RExp Dermatol.read the full storyWarburg effect, hair growth, immunological HF microenvironment
2021Human epithelial stem cell survival within their niche requires "tonic" cannabinoid receptor 1-signaling - Lessons from the hair follicleSugawara K, Zákány N, Tiede S, Purba T, Harries M, Tsuruta D, Bíró T, Paus RExp Dermatol.read the full storyendocannabinoid system, organ-cultured human HFs, human adult epithelial stem cell
2021Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging ResearchStone RC, Aviv A, Paus RJ Invest Dermatol.read the full storypigmentary unit, chemotherapy-induced alopecia, telogen effluvium, androgenetic alopecia, cicatricial alopecia
2021Dermal adipose tissue secretes HGF to promote human hair growth and pigmentationNicu C, O'Sullivan JDB, Ramos R, Timperi L, Lai T, Farjo N, Farjo B, Pople J, Bhogal R, Hardman JA, Plikus MV, Ansell DM, Paus RJ Invest Dermatol.read the full storyhepatocyte growth factor, human HF-dWAT co-culture, human hair growth, pigmentation
2021Shining a (blue) light on hair follicle chronobiology and photobiomodulationPaus RExp Dermatol.read the full storyhair follicles, metabolism, clock gene
2021Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactionsPlatt CI, Chéret J, Paus RArch Dermatol Res.read the full storymicrodissected scalp hair follicles, dermal papilla, 3-dimensional (3D) spheroids
2021Translational Neuroendocrinology of Human Skin: Concepts and PerspectivesRamot Y, Böhm M, Paus RTrends Mol Med.read the full storyneurohormones, neuropeptides, neurotransmitters, human skin physiology
2020Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse ModelGilhar A, Laufer Britva R, Keren A, Paus RJ Investig Dermatolread the full storyalopecia areata, therapeutic effects, preclinical
2020The Evolving Pathogenesis of Alopecia Areata: Major Open QuestionsPaus RJ Investig Dermatol.read the full storyautoimmune alopecia areata, atopic dermatitis, hair follicle
2020Mouse models of atopic dermatitis: a critical reappraisalGilhar A, Reich K, Keren A, Kabashima K, Steinhoff M, Paus RExp Dermatol. read the full storyatopic dermatitis, human skin xenotransplants, SCID mice
2020Towards a renaissance of dermatoendocrinology: Selected current frontiersBöhm M, Paus RExp Dermatol. read the full story
2020Re-innervation of human skin by rat dorsal root ganglia permits to study interactions between sensory nerve fibers and native human dermal mast cells ex vivoChéret J, Ponce L, Le Gall-Ianotto C, Bertolini M, Paus RExp. Dermatol.read the full storyhuman skin organ culture, functional sensory skin nerves, neurogenic skin inflammation
2020Clues that mitochondria are involved in the hair cycle clock: MPZL3 regulates entry into and progression of murine hair follicle cyclingNicu C, Wikramanayake TC, Paus RExp. Dermatol.read the full storyintrinsic oscillator system, myelin protein zero- like 3, telogen‐to‐anagen transition
2020Pro-inflammatory Vδ1 + T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair folliclesUchida Y, Gherardini J, Schulte-Mecklenbeck A, Alam M, Chéret J, Rossi A, Kanekura T, Gross CC, Arakawa A, Gilhar A, Bertolini M, Paus RJ Dermatol Sci. read the full storyskin-resident γδT-cells, alopecia areata, hair follicle, innate immunity
2020The Hair Follicle as an Interdisciplinary Model for Biomedical Research: An Eclectic Literature SynthesisHaslam IS, Paus RBioessaysread the full storyhuman hair growth, regeneration, hair loss therapy, stem cell niches
2020Translational Neuroendocrinology of Human Skin: Concepts and PerspectivesRamot Y, Böhm M, Paus RTrends Mol Med.read the full storyneurohormones, inflammatory skin, neuropeptides
2020The biology of human hair greyingO'Sullivan JDB, Nicu C, Picard M, Chéret J, Bedogni B, Tobin DJ, Paus RBiol Rev Camb Philos Soc.read the full storyanagen, hair follicle pigmentary unit, bulge melanocyte stem cells,
2020A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivoBertolini M, Chéret J, Pinto D, Hawkshaw N, Ponce L, Erdmann H, Jimenez F, Funk W, Paus RBr J Dermatol.read the full storyWnt signalling, hair growth, hypertrichosis, catagen development
2020Does dysfunctional autophagy contribute to immune privilege collapse and alopecia areata pathogenesis?Hardman JA, Nicu C, Tai C, Harries M, Mironov A, Purba TS, Paus RJ Dermatol. Sci.read the full storyautophagy, lysosomal degradation, ATG5, catagen,
2020Exploring the human hair follicle microbiomeLousada MB, Lachnit T, Edelkamp J, Rouillé T, Ajdic D, Uchida Y, Di Nardo A, Bosch TCG, Paus RBr. J Dermatol.read the full storymicrobiota, human holobiont, antimicrobial peptides, microbial survival
2020Inhibition of sonic hedgehog signaling via MAPK activation controls chemotherapy-induced alopeciaHaslam IS, Zhou G, Xie G, Teng X, Ao X, Yan Z, Smart E, Rutkowski D, Wierzbicka J, Zhou Y, Huang Z, Zhang Y, Farjo N, Farjo B, Paus R, Yue ZJ Invest Dermatol.read the full storyclinical oncology, hair matrix keratinocytes, Shh signaling, hair follicle damage
2020Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?Paus R, Ramot Y, Kirsner RS, Tomic-Canic MExp. Dermatol.read the full storytopical hormone therapy, thyroid hormone receptor, L‐thyroxine (T4), skin ulcers, telogen effluvium
2020Hair follicle immune privilege and its collapse in alopecia areataBertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus RExp. Dermatol.read the full storyMHC class, mast cells, CD4+, CD8+, NK cell, disease relapse
2020Topical Odorant Application of the Specific Olfactory Receptor OR2AT4 Agonist, Sandalore ® , Improves Telogen Effluvium-Associated ParametersJimenez F, López E, Bertolini M, Alam M, Chéret J, Westgate G, Rinaldi F, Marzani B, Paus R.J Cosmet Dermatol.read the full storyOR2AT4 olfactory receptor, Sandalore®, claim substantiation, hair growth, hair treatment, telogen effluvium
2020Vascular Endothelial Growth factor-A as a Promising Therapeutic Target for the Management of PsoriasisLuengas-Martinez A, Hardman-Smart J, Paus R, Young HS.Exp. Dermatol.read the full storyangiogenic mediator, bevacizumab, personalised medicine, vascular endothelial growth factor A
2020Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under "pathological" conditions ex vivoPost H, Hundt JE, Zhang G, Depping R, Rose C, Langan EA, Paus R.Arch Dermatol. Resread the full storyhypoxia, skin organ culture, Wound healing, preclinical
2020Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?Paus R, Ramot Y, Kirsner RS, Tomic-Canic MExp Dermatol.read the full storynuclear hormone receptors, wound healing, hair growth, telogen effluvium, triiodothyronine
2020Does mitochondrial dysfunction of hair follicle epithelial stem cells play a role in the pathobiology of lichen planopilaris?Hardman-Smart JA, Purba TS, Panicker S, Farjo B, Farjo N, Harries MJ, Paus R.Br J Dermatol.read the full storyT- cell mediated interferon-γ, immune privilege,
2020Vascular endothelial growth factor blockade induces dermal endothelial cell apoptosis in a clinically relevant skin organ culture modelLuengas-Martinez A, Hardman-Smart J, Rutkowski D, Purba TS, Paus R, Young HSSkin Pharmacol Physiolread the full storyanti-VEGF, endothelial cell apoptosis, human skin ex vivo, microvascular network, Psoriasis
2020Non‐neuronal kappa‐opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex vivoChéret J, Gherardini J, Soeberdt M, Hundt JE, Abels C, Bertolini M, Paus RJ Dermatolread the full storyneurogenic inflammation, human skin organ culture, keratinocyte apoptosis, inflammatory dermatoses
2020Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermisOláh A, Alam M, Chéret J, Kis NG, Hegyi Z, Szöllősi AG, Vidali S, Bíró T, Paus RExp Dermatolread the full storykeratinocyte mitochondrial activity, cannabinoid receptor 1, organ-cultured full-thickness human skin, ROS production, skin aging, photodamage
2020Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 SkewingDel Duca E, Ruano Ruiz J, Pavel AB, Sanyal RD, Song T, Gay-Mimbrera J, Zhang N, Estrada YD, Peng X, Renert-Yuval Y, Phelps RG, Paus R, Krueger JG, Guttman-Yassky E.Br J Dermatolread the full storylesional, nonlesional scalp biopsies, stem cells, follicular damage, JAK/STAT-targeting treatments
2020Hair(y) matters in melanoma biologyBarbara Bedogni, Ralf PausTrends in Molecular Medicineread the full storymetastatic melanoma, melanocytes, immune-privileged microenvironment, stem cells, melanoma prevention strategy
2020New effects of caffeine on CRH-induced stress along the intrafollicular classical HPA-axis (CRH-R1/2, IP3 -R, ACTH, MC-R2) and the neurogenic non-HPA-axis (substance P, p75NTR and TrkA) in ex vivo human male androgenetic scalp hair follicles.Fischer TW, Bergmann A, Kruse N, Kleszczynski K, Skobowiat C, Slominski AT, Paus RBr J Dermatolread the full storyhuman hair, androgenetic alopecia, stress-induced hair loss, hair organ culture model, caffeine
2020An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytesAlam M, Bertolini M, Gherardini J, Keren A, Ponce L, Chéret J, Alenfall J, Dunér P, Nilsson AH, Gilhar A, Paus RBr J Dermatolread the full storyhuman scalp skin xenotransplant, human hair follicle organ culture, hypertrichosis, hirsutism, hair growth
2020Adenosine promotes human hair growth and inhibits catagen transition in vitro - role of the outer sheath keratinocytes. Lisztes E, Toth BI, Bertolini M, Szabo IL, Zakany N, Olah A, Szollosi AG, Paus R, Biro T. J Invest Dermatolread the full storyhair follicle, ex vivo, organ culture, co-immunolabeling, G-protein, hair growth
2020Toward predicting the spatio-temporal dynamics of alopecia areata lesions using partial differential equation analysis.Atanaska Dobreva, Ralf Paus, N. G. Cogan Bull Math Biolread the full storyautoimmune disease, alopecia areata, partial differential equations, humanized mouse model
2020Fluoxetine promotes human hair follicle pigmentation ex vivo: Serotonin re-uptake inhibition as a new anti-greying strategy?Cheret J, Gherardini J, Bertolini M, Paus R. Br J Dermatolread the full storyhair follicle, ex vivo, organ culture, quantitative Masson-Fontana histomorphometry, serotonin receptor, melanotropic neurohormone
2020Do hair follicles operate as primitive, multifocal kidney-like excretory (mini-)organs?Carré JL, Suzuki T, Paus RExp Dermatolread the full storytrichocytes, hair shafts, classical nephrological therapy, erythropoietin synthesis
2020Neuroendocrinology and neurobiology of sebaceous gland.Clayton RW, Langan EA, Ansell DM, de Vos IJHM, Göbel K, Schneider MR, Picardo M, Lim X, van Steensel MAM, Paus RBiol Rev Camb Philos Socread the full storynervous system, pituitary control, sebaceous glands, homeostasis
2020Phytocannabinoid(-)-Cannabidiol operates as a complex, differential modular of human hair growth: Anti-inflammatory sub-micromolar versus hair growth inhibitory micromolar effects.Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro TJ Invest Dermatolread the full storyhair follicle, ex vivo organ culture, toll-like receptor, hair morphology
2020Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata.Laufer BR, Keren A, Paus R, Gilhar A.Br J Dermatolread the full storyhair loss, hair follicle, phosphodiesterase inhibitor, therapeutics
2020Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during subtance P-mediated neurogenic inflammation ex vivo.Gherardini J, Uchida Y, Hardman JA, Cheret J, Mace K, Bertolini M, Paus RPLoS Oneread the full storymacrophages, full-thickness skin organ culture, immunohistochemistry, neuroinflammatory stimulus
2020Schwann cells as underestimated, major players in human skin physiology and pathology. Bray ER, Cheret J, Yosipovitch G, Paus R. Exp Dermatolread the full storyaxon regeneration, wound healing, atopic dermatitis, psoriasis
2020Theophylline exerts complex anti-aging and anti-cytotoxicity effects in human skin ex vivo.Bertolini M, Ramot Y, Gherardini J, Heinen G, Cheret J, Welss T, Giesen M, Funk W, Paus R. Int J Cosmet Sciread the full storyfull thickness skin, organ culture, ex vivo, phosphodiesterase inhibitor, metallothionein‐1, collagen, skin‐protective properties
2019JAK inhibitors and alopecia areata.Gilhar A, Keren A, Paus R.Lancetread the full storysystemic therapy, cytokines, autoimmune disease
2019Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine.Gherardini J, Wegner J, Cheret J, Ghatak S, Lehmann J, Alam M, Jimenez F, Funk W, Bohm M, Botchkareva NV, Ward C, Paus R, Bertolini M.Int J Cosmet Sciread the full storyex vivo, organ culture, UV exposure, keratinocyte apoptosis, photoprotectants, clinical relevance
2019Nestin(+) progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo.Liao T, Lehmann J, Sternstein S, Yay A, Zhang G, Matthiessen AE, Schumann S, Siemers F, Kruse C, Hundt JE, Langan EA, Tiede S, Paus R.Arch Dermatol Resread the full storyskin punch biopsies, ex vivo, wound healing model, pre-clinical, regenerative medicine, chronic skin ulceration
2019Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle?Nicu C, Hardman JA, Pople J, Paus R.Exp Dermatolread the full storyhair follicle, transmission electron microscopy, anagen‐catagen transition, lipogenesis, hair cycle
2019Assessment of Quality of Life and Treatment Outcomes of Patients with persistent postchemotherapy alopecia.Freites-Martinez A, Chan D, Sibaud V, Shapiro J, Fabbrocini G, Tosti A, Cho J, Goldfarb S, Modi S, Gajria D, Norton L, Paus R, Cigler T, Lacouture ME.JAMA Dermatolread the full storypersistent chemotherapy-induced alopecia, clinical study, hair loss, patinets, dermatologic therapy
2019Hair growth control by innate immunocytes: Perifollicular macrophages revisited.Muneeb F, Hardman JA, Paus R.Exp Dermatolread the full storyhair matrix, hair cycle stage, hair follicle morphogenesis, Wnt signalling, clinically relevant
2019Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo.Zhang GY, Langan EA, Meier NT, Funk W, Siemers F, Paus R.PLoS Oneread the full storyfull thickness human skin, wound healing organ culture model, quantitative immunohistomorphometry, pre-clinical testing, keratin expression, energy metabolism
2019Distinct patterns of hair graft Survival After Transplantation into 2 Nonhealing Ulcers: Is Location Everything?Alam M, Cooley J, Plotczyk M, Martinez-Martin MS, Izeta A, Paus R, Jimenez F.Dermatol Surgread the full storyhair follicles, scar formation, hair growth, wound healing, human skin
2019Image Gallery: Optical coherence tomography for intravital human hair follicle analyses ex vivo.Lehmann J, Kemper B, Barroso Pena A, Schnekenburger J, Paus R, Bertolini M, Cheret J.Br J Dermatolread the full storylabel‐free, high‐resolution, anatomical details, ex vivo, organ culture, hair matrix
2019Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis.Leon A, Rosen JD, Hashimoto T, Fostini AC, Paus R, Yosipovitch G.Exp Dermatolread the full storyhair follicle, mast cells, neurogenic inflammation, psoriatic scalp itch, immunogenic inflammation
2019Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis.Clayton RW, Gobel K, Niessen CM, Paus R, van Steensel MAM, Lim X.Br J Dermatolread the full storygenetic mouse models, mammalian skin, acne vulgaris, comedones, acne pathogenesis
2019Hair disorders in patients with cancer.Freites-Martinez A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME.J Am Acad Dermatolread the full storychemotherapy induced alopecia, hair repigmentation, immunotherapies, oncology patients
2019Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias.Harries M, Imanishi H, Paus R.J Am Acad Dermatolread the full storylaser capture microdissection, microarray analysis, hair follicle, immune privilege collapse, follicular inflammation
2019TRPV4 is expressed in human hair follicles and inhibits hair growth in vitro.Szabo IL, Herczeg-Lisztes E, Szegedi A, Nemes B, Paus R, Biro T, Szollosi AG.J Invest Dermatolread the full storycalcium permeable, microflorimetric Ca2+ measurement, outer root sheath keratinocytes, peripheral sensory nerves
2019Growth hormone operates as a neuroendocrine regulator of human hair growth ex vivo. Alam M, Below DA, Cheret J, Langan EA, Bertolini M, Jimenez F, Paus R.J Invest Dermatol read the full storyhuman hair follicle, ex vivo, organ culture, mini-organ, neuropeptides, pigmentation
2019Alopecia areata patients show deficiency of FOXP3+CD39+ T regulartory cells and clonotypic restriction of Treg TCRß-chain, which highlights the immunopathological aspect of disease.Hamed FN, Astrand A, Bertolini M, Rossi A, Maleki Dizaji A, Messanger AG, Mc Donagh AJG, Tazi-Ahnini R. PloS Oneread the full storyflow cytometry, next Generation Sequencing, hair loss, Treg clonotypes, autoimmune reaction
2019Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation. Hawkshaw NJ, Hardman JA, Alam M, Jimenez F, Paus R. Br J Dermatolread the full storyin situ hybridization, human telogen, scalp hair follicle sections, hair biology
2019Inhibition of ATP binding cassette transporter B1 sensitizes human hair follicles to chemotherapy-induced damage.Smart E, Farjo N, Farjo B, Haslam IS, Paus R.J Dermatol Sciread the full storyquantitative immunohistomorphometry, 4-hydroxycyclophosphamide, anthracycline doxorubicin, ex vivo, proliferation, apoptosis
2019The Phytocannabinoid (-)-Cannabidiol operates as a complex, differential modulator of human hair qrowth: anti-inflammatory submicromolar versus hair growth inhibitory micromolar effects.Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro T. J Invest Dermatolread the full storyhair follicle, organ culture, hair shaft, hair cycle, hair matrix keratinocytes
2019Seborrheic dermatitis-Looking beyond Malassezia. Wikramanayake TC, Borda LJ, Miteva M, Paus R. Exp Dermatolread the full storychronic, relapsing inflammatory, skin disease, Mpzl3 knockout mice, epidermal barrier, sebaceous activity
2019CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia.Purba TS, Ng'andu K, Brunken L, Smart E, Mitchell E, Hassan N, O'Brien A, Mellor C, Jackson J, Shahmalak A, Paus R. EMBO Mol Med read the full storyhair follicle, organ culture, epithelial bulge stem cell analysis, chemotherapy, paclitaxel, docetaxel, mitotic defects
2019PPAR-Y signalling as a key mediator of human hair follicle physiology and pathology. Ramot Y, Bertolini M, Bobolijava M, Uchida Y, Paus R. Exp. Dermatolread the full storyhair follicle development, scarring alopecia, epithelial-mesenchymal transition, androgenetic alopecia
2019Precilinal evidence that PPARγ- modulator, N-Acetyl-GED-0507-34-Levo, may protect human hair follicle epithelial stem cells against lichen planopilaris -associated damage.Cheret J, Piccini I, Hardman-Smart J, Ghatak S, Alam M, Lehmann J, Jimenez F, Erdmann H, Poblet E, Botchkareva N, Paus R, Bertolini M. J Eur Acad Dermatol Vernereolread the full storyhair follicle, ex vivo, organ culture, immunohistochemistry, NAGED, hair loss, lichen planopilaris
2019Mineralocorticoid receptor antagonists stimulate human hair growth ex vivo. Hundt JE, Sass S, Funk W, Biro T, Farman N, Langan EA, Paus R. Skin Pharmacol Physiolread the full storyhair follicle, ex vivo, organ culture, glucocorticoid, hair cycle
2019Y-27632 preserves epidermal intregity in a human skin-organ culture (h-SOC) system by regulating AKT and ERK signalling pathways.Zang X, Qin J, Xie Z, Liu C, Su Y, Chen Z, Zho Q, Ma C, Liu G, Paus R, Guo J, Wu X. J Dermatol Sciread the full storyhuman breast skin, organ culture, ex vivo, epidermal cell proliferation, immunofluorescence staining, ROCK inhibitor, epidermal architecture
2019Frontiers in alopecia areata pathobiology research.Gilhar A, Britva RL, Keren A, Paus R.J Allergy Clin Immunolread the full storyhumanized mouse model, autoantigens, regulatory T cells, immune privilege
2019Human perifollicular macrophages undergo apoptosis, express Wnt ligands and switch their polarization during catagen.Hardman JA, Muneeb F, Pople J, Bhogal R, Shahmalak A, Paus R. J Invest Dermatolread the full storyhuman hair follicle, ex vivo, organ culture, hair cycle, inflammatory hair disease
2019Model-based approach to the design of pharmaceutical roller-compaction processes.Toson P, Lopes DG, Paus R, Kumar A, Geens J, Stibale S, Quodbach J, Kleinebudde P, Hsiao WK, Khinast J. Int J Pharmread the full storymathematical model, in-silico, ibuprofen formulations, iterative calibration
2018Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-alpha administration differ during wound repair and regeneration.Abarca-Buis RF, Martinez-Jimenez A, Vera-Gomez E, Contreras-Figueroa ME, Garciadiego-Cazares D, Paus R, Robles-Tenorio A, Krotzsch E. Differentiation read the full storyear punch wound mouse model, histology analysis, fibrotic scarring, epidermal apoptosis
2018Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management.Paus R, Bulfone-Paus S, Bertolini M. J Investig Dermatol Symp Procread the full storyhair bulb, pharmacological manipulation, Immune privilege collapse-related autoimmune diseases
2018An efficient method for eccrine gland isolation from human scalp.Jimenez F, Alam M, Hernandez I, Poblet E, Hardman JA, Paus R. Exp Dermatolread the full storyhair graft harvesting method, calp follicular unit grafts, microdissection, methylene blue staining
2018NF-kappaB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types.Krieger K, Millar SE, Mikuda N, Krahn I, Kloepper JE, Bertolini M, Scheidereit C, Paus R, Schmidt-Ullrich R.J Invest Dermatolread the full storyhumanized mouse model, hair cycle analysis, histological techniques, anagen induction, telogen−anagen transition
2018Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue.Poblet E, Jimenez F, Escario-Travesedo E, Hardman JA, Hernandez-Hernandez I, Agudo-Mena JL, Cabrera-Galvan JJ, Nicu C, Paus R. Br J Dermatolread the full story3D reconstruction, human scalp, follicular unit transplant grafts, scalp strip ex vivo, human skin adnexa
2018Epithelial-to-mesenchymal stem cell transition in a human organ: Lessons from lichen planopilaris.Imanishi H, Ansell DM, Cheret J, Harries M, Bertolini M, Sepp N, Biro T, Poblet E, Jimenez F, Hardman J, Panicker SP, Ward CM, Paus R.J Invest Dermatolread the full storyhair follicle, ex vivo organ culture, immunohistochemistry, transmission electron microscopy, preclinical assay
2018Prolactin as a candidate sebotrop(h)ic hormone?Langan EA, Hinde E, Paus R. Exp Dermatolread the full storyhuman dermatoses, sebaceous gland, therapeutic strategies, cutaneous ageing
2018 A guide to studying human dermal adipocytes in situ.Nicu, C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. Exp Dermatolread the full storyquantitative immunohistomorphometry, dermal white adipose tissue, in situ hybridization, neuroendocrinology
2018Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture.Parodi C, Hardman JA, Allavena G, Marotta R, Catelani T, Bertolini M, Paus R, Grimaldi B.  PLoS Biolread the full storycell culture, quantitative immunohistomorphometry, ex vivo, knockdown, preclinical research model
2018Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg total deletion.Sardella C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F. J Invest Dermatolread the full storyhumanized mouse model, skin grafts, in vivo, gene expression, adipose tissue-mediated signals
2018Melatonin: A cutaneous perspective on its production, metabolism, and functions.Slominski AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ, Paus R. J Invest Dermatolread the full storyhair follicle, photo-protection, anti-cancer activity, wound healing, pigmentation, inflammatory dermatoses
2018Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal. Foster AR, Nicu C, Schneider MR, Hinde E, Paus R. Arch Dermatol Resread the full story in vivo BODIPY, immunohistomorphometry, wound healing, adipocyte hypertrophy
2018Lichen planopilaris and frontal fibrosing alopecia as model epithelial stem cell diseases.Harries MJ, Jimenez F, Izeta A, Hardman J, Panicker SP, Poblet E, Paus R. Trends Mol Medread the full storyhair follicle, PPAR-γ, epithelial-mesenchymal transition, immune-privilege
2018Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles.Hawkshaw NJ, Hardman JA, Haslam IS, Shahmalak A, Gilhar A, Lim X, Paus R.PLoS Biolread the full storyhair follicle, ex vivo organ culture, Quantitative immunohistomorphometry, bioinformatics, immunosuppressant, therapeutic strategy
2018How UV light touches the brain and endocrine system through skin, and why.Slominski AT, Zmijewski MA, Plonka PM, Szaflarski JP, Paus R. Endocrinologyread the full storyenvironmental factors, UV radiation, body homeostasis, neuro-endocrine system
2018Image Gallery: Intravital visualization of the dynamic changes in human hair follicle cycling.Alam M, Hernandez I, Paus R, Jimenez F.Br J Dermatolread the full storyanagen, catagen, telogen, methylene blue staining, hair cycle stage
2018Topically applied nicotinamide inhibits human hair follicle growth ex vivo.Haslam IS, Hardman JA, Paus R. J Invest Dermatolread the full storyorgan culture, microdissected human scalp hair follicles, hair growth inhibitor, catagen, mast cells
2018Re-investigating the basement membrane zone of psoriatic epidermal lesions: Is laminin-511 a new player in psoriasis pathogenesis?Natsumi A, Sugawara K, Yasumizu M, Mizukami Y, Sano S, Morita A, Paus R, Tsuruta D.J Histochem Cytochemread the full storyskin tumorectomy, immunohistochemistry, transmission electron microscopy, laminin-511, keratinocyte growth/death
2018Cover Image: Neuroendocrine treatment of inherited keratin disorders by cannabinoids?Ramot Y, Olah A, Paus R.Br J Dermatolread the full storyuman skin organ culture, ex vivo, epidermolytic ichthyosis, keratin disorders, cannabinoid signalling
2018iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata. Ghraieb A, Keren A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A.J Autoimmunread the full storyhumanized mouse model, xenotransplants, lymphocytes, therapeutic potential
2018Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin.Keren A, Shemer A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A. J Allergy Clin Immunolread the full storyhumanized mouse model, sublethal irradiation, immunohistochemical analysis, cytokine analyses, psoriatic lesions
2018Peroxisome Proliferator-Activated Receptor-gamma-Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium.Ramot Y, Alam M, Olah A, Biro T, Ponce L, Cheret J, Bertolini M, Paus R.J Invest Dermatolread the full story ex vivo organ culture, gene expression, N-Acetyl-GED, mitochondrial function, ORS keratinocytes
2018Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling.Dobreva, A, Paus R, Cogan NG.Math Med Biol read the full storymathematical modelling, anagen phase interruption, therapeutic targets
2018Visualization of global RNA synthesis in a human (mini-) organ in situ by click chemistry.Purba TS, Marsh J, Ng'andu K, Kurinna S, Paus R. Biotechniquesread the full storyhuman hair follicle, ex vivo organ culture, in situ RNA synthesis, 5-ethynyl uridine
2018Bridging the "Dead hair"-"live follicle" divide in applied hair research.Bertolini M, Botchkareva N, Westgate G, Ward C, Cornwell P, Paus R. J Cosmet Sciread the full story synopsis, mini-organ, hair shaft structure
2018Olfactory receptor OR2AT4 regulates human hair growth.Cheret J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M, Hatt H, Paus R. Nat Communread the full storyex vivo, organ culture, knockdown, histological analysis, genome-micro array analysis, sandalore, synthetic sandalwood, hair growth, hair loss therapy
2018A technique for more precise distinction between catagen and telogen human hair follicles ex vivo. Hernandez I, Alam M, Platt C, Hardman J, Smart E, Poblet E, Bertolini M, Paus R, Jimenez F. J Am Acad Dermatolread the full storyex vivo organ culture, hair cycle stage, macroscopic analysis 
2018Transcriptional programming of normal and inflamed human epidermis at single-cell resolution. Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ.Cell Repread the full storycomputational analysis, single-cell RNAseq, keratinocyte 
2018Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P-induced human mast cell activation and degranulation in the hair follicle.Jadkauskaite L, Bahri R, Farjo N, Farjo B, Jenkins G, Bhogal R, Haslam I, Bulfone-Paus S, Paus R. J Allergy Clin Immunolread the full story ex vivo organ culture, immunohistochemistry, mast cells degranulation and activity assay, neuropeptide, androgenetic alopecia, alopecia areata
2018Bi-allelic mutations in LSS, encoding lanosterol synthase, cause autosomal-recessive hypotrichosis simplex.Romano, MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmuller J, Nurnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lutjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC.Am J Hum Genetread the full storywhole-exsome sequencing, alopecia, cholesterol biosynthetic pathway, lanosterol synthase
2018The renaissance of human skin organ culture: A critical reappraisal. Zhou L, Zhang X, Paus R, Lu Z.Differentiationread the full storyex vivo, morphological analyses, gene silencing, assays
2018Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding?Langan EA, Fink T, Paus R. Arch Dermatol Resread the full storyex vivo, human skin organ culture, PRL receptor antagonists, keratinocyte differentiation
2018Retinoic acid co-treatment aggravates severity of dioxin-induced skin lesions in hairless mice via induction of inflammatory response.Rudyak SG, Usakin LA, Tverye EA, Orekhov AS, Belushkina NN, Paus R, Paltsev MA, Panteleyev AA.Biochem Biophys Res Communread the full storyhumanized mouse model, halogenated polyaromatic hydrocarbons, skin pathologies, keratinocyte
2017Oxidative damage control in a human (mini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition.Haslam IS, Jadkauskaite L, Szabo IL, Staege S, Hesebeck-Brinckmann J, Jenkins G, Bhogal RK, Lim FL, Farjo N, Farjo B, Biro T, Schafer M, Paus R. J Invest Dermatol read the full storyhuman hair follicle, organ culture, ex vivo, quantitative immunofluorescence, ROS, keratinocytes
2017Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nothen MM.Nat Communread the full storygeno-wide analysis, meta-analysis, hair follicle cycling, therapeutics
2017Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology.Jumper N, Hodgkinson T, Paus R, Bayat A. PLoS Oneread the full storysite-specific in situ microdissection, transcriptome array analysis, 2D cell culture, TGFβ-mediated signaling
2017Enhanced neurogenic biomarker expression and reinnervation in human acute skin wounds treated by electrical stimulation.Sebastian A, Volk SW, Halai P, Colthurst J, Paus R, Bayat A. J Invest Dermatolread the full storyHuman punch biopsy, wound healing, microarray analysis, in vivo repair, neuroblastoma
2017Cover Image: Are melanocyte-associated peptides the elusive autoantigens in alopecia areata?Bertolini M, Rossi A, Paus R.Br J Dermatolread the full storyhair follicle, hair matrix melanocytes, mast cells, autoantigens, melanogenesis
2017Regulatory T cells in skin facilitate epithelial stem cell differentiation. Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. Cellread the full storyimmune-profiling, immunofluorescent microscopy, in vivo mouse model, skin inflammation, telogen-anagen transition, Jagged 1, hair regeneration, alopecia areata
2017Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1beta-mediated signaling.Stojadinovic O, Wikramanayake TC, Villasante Fricke AC, Yin NC, Liang L, Hinde E, Escandon J, Tomic-Canic M, Ansell DM, Paus R, Jimenez JJ. Heliyonread the full storyKeywords: incisional wound induction, histological analysis, cytokine injection, Gene expression profiling, hair cycle, IL-1β signaling
2017Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmuller J, Stander S, Luger T, Paus R, Cheret J, Hatt H.Exp Dermatolread the full storyhuman keratinocytes culture, cAMP‐dependent pathway, skin diseases, wound repair
2017Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?Jadkauskaite L, Coulombe PA, Schafer M, Dinkova-Kostova AT, Paus R, Haslam IS.Bioessaysread the full storyredox homeostasis, NRF2 activation, hair follicle pathologies
2017E-cadherin-mediated cell contact controls the epidermal damage response in radiation dermatitis.Xie G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H, Ramot Y, Paus R, Yue Z.J Invest Dermatolread the full storyhuman skin biopsy, footpad mouse model, in vivo rescue, epidermal keratinocytes, radiotherapy
2017Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix.Purba TS, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, Ceballos L, Gandarillas A, Paus REur J Cell Biol read the full storyhuman hair follicle, ex vivo organ culture, in situ hybridisation, CIP/KIP proteins, hair bulb growth
2017T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle.Oelert T, Gilhar A, Paus R. Exp Dermatolread the full storyhair follicle, immune privilege collapse, CD4+ regulatory T cells, alopecia areata
2017A role for neuregulin-1 in promoting keloid fibroblast migration via ErbB2-mediated signaling.Jumper N, Hodgkinson T, Paus R, Bayat A. Acta Derm Venereol read the full storylaser capture microdissection, in situ gene expression profiling, NRG1/ErbB2/Src/PTK2 signaling pathway, fibroproliferative tumour
2017Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2.Purba TS, Peake M, Farjo B, Farjo N, Bhogal RK, Jenkins G, Paus R. Sci Repread the full storyex vivo, hair follicle organ culture, Immunofluorescence, Quantitative immunohistomorphometry, epithelial stem cells
2016Hair follicle bulge stem cells appear dispensable for the acute phase of wound re-epithelialization. Garcin CL, Ansell DM, Headon DJ, Paus R, Hardman MJ. Stem Cellsread the full story wound healing, transgenic mice, in vivo
2016An innovative approach to dissecting keloid disease leading to identification of the retinoic acid pathway as a potential therapeutic target.Jumper N, Paus R, Bayat A. Plast Reconstr Surg Glob Openread the full storyskin biopsies, laser capture microdissection, epidermis
2016A Guide to studying human hair follicle cycling in vivo.Oh JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS, Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV.J Invest Dermatolread the full storypre-clinical, xenograft, immuno-histochemistry
2016Lhx2 is a direct NF-kappaB target gene that promotes primary hair follicle placode down-growth.Tomann P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R. Development read the full storygene expression, transcriptome, embryos, cell migration
2016Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice.Dahlhoff M, Camera E, Schafer M, Emrich D, Riethmacher D, Foster A, Paus R, Schneider MR.Developmentread the full storygene targeting, mouse line, in vivo, meibomian gland disease
2016p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a rat model of radiation dermatitis.Liao C, Xie G, Zhu L, Chen X, Li X, Lu H, Xu B, Ramot Y, Paus R, Yue Z. J Invest Dermatol read the full storychip analysis, in vivo, therapeutic targeting, dermatoses
2016Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse.Bertolini M, Pretzlaff M, Sulk M, Bahr M, Gherardini J, Uchida Y, Reibelt M, Kinori M, Rossi A, Biro T, Paus R.Br J Dermatolread the full storyhair follicle organ culture, immuno‐histomorphometry, autoimmune disorder
2016A primer for studying cell cycle dynamics of the human hair follicle. Purba TS, Brunken L, Hawkshaw NJ, Peake M, Hardman J, Paus R. Exp Dermatol read the full storyimmuno-labelling, cell cycle, proliferation, apoptosis
2016Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue.Bagabir RA, Syed F, Shenjere P, Paus R, Bayat A.J Invest Dermatol read the full storymolecular diagnostic, biomarker, immunohistochemistry, dermal scarring
2016Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.Gilhar A, Schrum AG, Etzioni A, Waldmann H, Paus R.Autoimmun Revread the full storyxenografts, transplantation, SCID mice, therapeutic strategies
2016The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease.Jumper N, Hodgkinson T, Arscott G, Har-Shai Y, Paus R, Bayat A.J Invest Dermatol read the full storylaser capture microdissection, microarray, luciferase assay, metabolism
2016The gut-skin axis in health and disease: A paradigm with therapeutic implications.O'Neill CA, Monteleone G, McLaughlin JT, Paus R. Bioessaysread the full storymicrobiota, signaling pathways, skin co‐morbidities
2016The thyroid hormone analogue KB2115 (Eprotirome) prolongs human hair growth (anagen) ex vivo.Olah A, Gherardini J, Bertolini M, Cheret J, Ponce L, Kloepper J, Biro T, Soeberdt M, Abels C, Paus R. J Invest Dermatolread the full storyhuman scalp hair follicle, organ culture, hair cycle, translational human hair research
2016Exploring the "brain-skin connection": Leads and lessons from the hair follicle.Paus R. Curr Res Transl Medread the full storyhuman hair follicle, organ culture, neuro-hormone, skin epithelium, Melatonin
2016Biology of the eyelash hair follicle: an enigma in plain sight. Paus R, Burgoa I, Platt CI, Griffiths T, Poblet E, Izeta A. Br J Dermatol read the full storymini-organ culture, greying, cosmetic manipulation
2016Mutations in TSPEAR, encoding a regulator of notch signaling, affect tooth and hair follicle morphogenesis.Peled A, Sarig O, Samuelov L, Bertolini M, Ziv L, Weissglas-Volkov D, Eskin-Schwartz M, Adase CA, Malchin N, Bochner R, Fainberg G, Goldberg I, Sugawara K, Baniel A, Tsuruta D, Luxenburg C, Adir N, Duverger O, Morasso M, Shalev S, Gallo RL, Shomron N, Paus R, Sprecher E.PLoS Genetread the full storysiRNA, NOTCH1 reporter assay, knockdown in mice hair follicles, organ cultures, apoptosis, ectodermal dysplasias
2016 Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit? Poblet E, Jimenez-Acosta F, Hardman JA, Escario E, Paus R. Exp Dermatol read the full story3D imaging, scalp follicular units, skin appendages
2016Thyroid hormones enhance mitochondrial function in human epidermis.Vidali S, Cheret J, Giesen M, Haeger S, Alam M, Watson REB, Langton AK, Klinger M, Knuever J, Funk W, Kofler B, Paus R.J Invest Dermatolread the full story Human skin organ culture, ex vivo, immunohistochemistry, Transmission electron microscopy, In situ zymography, skin aging, mitochondrial function
2016Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis.Fleger-Weckmann A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. Matrix Biol read the full story Hair follicle formation, histological analysis, electron microscopy, mouse model, hair shaft differentiation, basement membrane