Our Publications
= Highlight publication
Year | Title | Author | Journal | Link | Keywords |
---|---|---|---|---|---|
2023 | Preliminary evidence that Merkel cells exert chemosensory functions in human epidermis | Piccini I, Chéret J, Tsutsumi M, Sakaguchi S; Ponce L, Almeida, L, Funk W, Kückelhaus M; Kajiya K, Paus R, Bertolini M | Exp Dermatol | read the full story | Merkel cell, Chemosensation, Olfactory receptor, Vesicle release |
2023 | mTORC1 activity negatively regulates human hair follicle growth and pigmentation | Suzuki T, Chéret J, Dinelli Scala F, Akhundlu A, Gherardini J, Demetrius D, O'Sullivan JDB, Kuka Epstein G, Bauman AJ, Demetriades C, Paus R | EMBO Reports | read the full story | Canities, Hair follicle pigmentation, Hair follicle organ culture, Melanogenesis, mTORC1 signaling |
2023 | Differential regulation of IL-17A and IL-17F via STAT5 contributes to psoriatic disease | Cole S, Manghera A, Burns L, Barrett J, Yager N, Rhys H, Skelton A, Cole J, Goodyear CS, Griffiths M, Baeten M, Bertolini M, Shaw S, Al-Mossawi H, Maroof A | Journal of Allergy and Clinical Immunology | read the full story | Psoriasis, IL-17 signaling, STAT signaling, lesional skin organ culture, scRNAseq |
2023 | Laser capture microdissection as a method for investigating the human hair follicle microbiome reveals region-specific differences in the bacteriome profile | Lousada MB, Edelkamp J, Lachnit T, Fehrholz M, Jimenez F, Paus R | BMC Research Notes | read the full story | Hair follicle organ culture, Microbiome, Laser-Capture Microdissection |
2023 | Involvement of ILC1-like innate lymphocytes in human autoimmunity: lessons from alopecia areata | Laufer Britva R, Keren A, Bertolini M, Ullmann Y, Paus R, Gilhar A | eLife | read the full story | Alopecia Areata, Hair Loss, Hair growth, Humanized mouse model, innate lymphoid cells-type 1 |
2023 | Application of topical Sandalore® increases epidermal dermcidin synthesis in organ-cultured human skin ex vivo | Edelkamp J, Lousada MB, Pinto D, Chéret J, O'Sullivan JDB, Biundo A, Jimenez F, Funk W, Roessing C, Rippmann V, Paus R, Bertolini M | Skin Pharmacol. Physiol. | read the full story | Skin organ culture, Chemosensation, Olfactory Receptors, Microbiome, Antimicrobial peptides |
2023 | Concentration-dependent stimulation of melanin production as well as melanocyte and keratinocyte proliferation by melatonin in human eyelid epidermis | Sevilla A, Chéret J, Lee W, Paus R | Exp. Dermatol. | read the full story | Full-thickness eyelid skin organ culture, melatonin, melanogenesis, |
2023 | Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants | Keren A, Reich K, Bertolini M, Moga A, Riethmüller C, Ullmann Y, Paus R, Gilhar A | Allergy | read the full story | Atopic Dermatitis; humanized mouse model; xenotransplants; skin barrier deficits |
2022 | Human Hair Follicles Operate a Functional Peripheral Equivalent of the Hypothalamic-Pituitary-Somatotropic Axis Ex Vivo | Horesh EJ, Gherardini J, Alam M, Rodriguez-Feliz J, Bauman AJ, Chéret J, Paus R | JID | read the full story | HF organ culture ex vivo; HPS-Axis; brain-HF-axis; neuroendocrinology |
2022 | Downregulation of pathogenic MICA-NKG2D interactions as a novel strategy in alopecia areata management: a new rationale for adjunct statin therapy? | Gherardini J, Rivas KE, Chéret J, Strbo N, Paus R | JEADV | read the full story | Outer Root Sheath Keratinocytes; in vitro models, Alopecia Areata; IP collapse |
2022 | Mitochondrially Localized MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte Proliferation | Wikramanayake TC, Nicu C, Gherardini J, Mello ACGCV, Chéret J, Paus R | JID | read the full story | Sebaceous gland function, MPZL3 |
2022 | The impact of perceived stress on the hair follicle: Towards solving a psychoneuroendocrine and neuroimmunological puzzle | O'Sullivan JDB , Peters EMJ, Amer Y, Atuluru P, Chéret J, Rosenberg AM, Picard M, Paus R | Front Neuroendocrinol. | read the full story | brain-HF axis; perceived stress in hair greying and hair loss, neuroendocrinology |
2022 | Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactions | Platt CI, Cheret J, Paus R | Arch Dermatol Res. | read the full story | Organotypic model, 3D dermal papilla spheroids, Epithelial mesenchymal interaction, hair matrix |
2022 | A plaidoyer for the use of human skin xenotransplant mouse models in preclinical psoriasis research | Gilhar A, Reich K, Keren A, Paus R | J Eur Acad Dermatol Venereol. | read the full story | Psoriasis, humanized mouse model, xenotransplantation |
2022 | Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype | Piccini I, Sousa M, Altendorf S, Jimenez F, Rossi A, Funk W, Biró T, Paus R, Seibel J, Jakobs M, Yesilkaya T, Edelkamp J, Bertolini M | Nutrients. | read the full story | Female pattern hair loss, hair follicle, metabolism, nutrient supplementation |
2022 | Circadian rhythms in psoriasis and the potential of chronotherapy in psoriasis management | Luengas-Martinez A, Paus R, Iqbal M, Bailey L, Ray DW, Young HS | Exp. Dermatol | read the full story | VEGF-A, chronotherapy, circadian rhythms, psoriasis. |
2022 | Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational Horizons | Senna MM, Peterson E, Jozic I, Chéret J, Paus R | JID Innov. | read the full story | 5α-reductase inhibitor, alopecia areata, androgenetic alopecia, corticotropin-releasing hormone, epithelial‒mesenchymal transition, frontal fibrosing alopecia, hair follicle, immune privilege, keratin, keratinocyte, lichen planopilaris, macrophage, major histocompatibility complex, primary cicatricial alopecia, personal care product, peroxisome proliferator–activated receptor-γ, stem cell, substance P, epithelial hair follicle stem cell, α-melanocyte-stimulating hormone |
2022 | Hydra and the hair follicle - An unconventional comparative biology approach to exploring the human holobiont | Lousada MB, Lachnit T, Edelkamp J, Paus R, Bosch TCG | Bioessays. | read the full story | Antimicrobial peptides, microbial ecology, microbiome, model organisms |
2022 | Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging | Wikramanayake TC, Chéret J, Sevilla A, Birch-Machin M, Paus R | Expert opinion on Therapeutic Targets | read the full story | Reactive oxygen species (ROS), alopecia, appendage, epidermis, hair follicle, mitochondria, myelin protein zero-like 3 (MPZL3), sebaceous gland, skin cancer |
2022 | Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective | Sevilla A, Chéret J, Slominski RM, Slominski AT, Paus R | J. Pineal res | read the full story | Hair follicle, human skin, melanocyte, melatonin, pigmentation |
2022 | An extract of Leontopodium alpinum inhibits catagen development ex vivo and increases hair density in vivo | Campiche R, Le Riche A, Edelkamp J, Fernandez Botello A, Martin E, Gempeler M, Bertolini M | Int J Cosmet Sci. | read the full story | Leontopodium alpinum, anagen phase, anti-hair loss, hair follicle, hair growth, versican |
2022 | Human organ reju-venation by VEGF-A: Lessons from the skin | Keren A, Bertolini M, Yaniv K, Ullmann Y, Paus R, Gilhar A | Sci. Advances | read the full story | VEGF-A, skin aging, skin rejuvenation, humanized mouse model, skin organ culture ex vivo |
2022 | Effect of minoxidil formulations on human scalp skin xenotransplants on SCID mice: A novel pre-clinical in vivo assay for androgenetic alopecia research | Gilhar A, Keren A, Ullmann Y, Wu J, Paus R | Exp Dermatol. | read the full story | Mouse model, xenotransplant, preclinical model, hair growth, hair loss, androgenetic alopecia |
2022 | Growth Hormone and the Human Hair Follicle | Horesh E.J, Chéret J, Paus R | Int J Mol Sci. | read the full story | Growth hormone, neuroendocrine, hair follicle, hair growth |
2021 | The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendages | Yue ZC, Lei MX, Paus R, Chuong CM | Biol Rev Camb Philos Soc. | read the full story | VGEF, psoriasis, therapeutic strategies |
2021 | Adiponectin negatively regulates pigmentation, Wnt/β-catenin and HGF/c-Met signalling within human scalp hair follicles ex vivo | Nicu C, Jackson J, Shahmalak A, Pople J, Ansell D, Paus R | Arch Dermatol Res. | read the full story | hair follicle, adiponectin, pigmentation, hair follicle organ culture, ex vivo, dermal papilla, WNT |
2021 | Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldness | Hochfeld L.M, Bertolini M, Broadley D, Botchkareva N.V, Betz R.C, Schoch S, Nöthen M.M, Heilmann-Heimbach S. | PLoS One. | read the full story | hair follicle, male pattern hair loss, WNT, genetic |
2021 | Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase | Figlak k, Williams G, Bertolini M, Paus R, Philpott M.P. | Sci Rep. | read the full story | hair follicle, metabolism, outer root sheath keratinocytes, hair follicle organ culture, ex vivo |
2021 | Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle | Uchida Y, Gherardini J, Pappelbaum K, Chéret J, Schulte-Mecklenbeck A, Gross CC, Strbo N, Gilhar A, Rossi A, Funk W, Kanekura T, Almeida L, Bertolini M, Paus R. | J Autoimmun. | read the full story | alopecia areata, autoimmunity, resident human γδT-cells, hair follicle, MICA, NKG2D, stress, ex vivo model |
2021 | The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targets | Suzuki T, Ito T, Gilhar A, Tokura Y, Reich K, Paus R. | Exp Dermatol. | read the full story | hair growth, skin, psoriasis, hair follicle |
2021 | PPARγ signaling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transition | Piccini I, Brunken L, Chéret J, Ghatak S, Ramot Y, Alam M, Purba TS, Hardman J, Erdmann H, Jimenez F, Paus R, Bertolini M. | Br J Dermatol. | read the full story | alopecia, chemotherapy, treatment, prevention, PPARγ agonist |
2021 | Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology. | Wikramanayake TC, Nicu C, Chéret J, Czyzyk TA, Paus R. | Bioessays. | read the full story | Myelin Protein Zero-like 3, CLOCK, PPARγ, mitochondria |
2021 | A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism? | Limbu SL, Purba TS, Harries M, Wikramanayake TC, Miteva M, Bhogal RK, O'Neill CA, Paus R. | Bioessays. | read the full story | dandruff, scalp, hair follicle, cosmeceuticals |
2021 | Quantitative mapping of human hair greying and reversal in relation to life stress | Rosenberg AM, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Kumar Soni R, Lacefield C, Tobin DJ, Paus R, Picard M. | Elife. | read the full story | stress, premature greying, hair shaft proteomics |
2021 | A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia? | Ivan Jozic, Jérémy Chéret, Beatriz Abdo Abujamra, Mariya Miteva, Jennifer Gherardini, Ralf Paus | Biomedicines | read the full story | caveolin-1, scarring alopecia, hair follicle stem cells, immune privilege collapse |
2021 | Sensory re-innervation of human skin by human neural stem cell-derived peripheral neurons ex vivo | Chéret J, Piccini I, Gherardini J, Ponce L, Bertolini M, Paus R. | J Invest Dermatol. | read the full story | skin explants, re-innervation, iPS cells |
2021 | Transduction-induced overexpression of Merkel cell T antigens in human hair follicles induces formation of pathological cell clusters with Merkel cell carcinoma-like phenotype | Thibault Kervarrec, Jérémy Chéret, Ralf Paus, Roland Houben, David Schrama | Exp Dermatol. | read the full story | Merkel cells, carcinoma, polyomavirus, hair follicle, malignant transformation, tumor |
2021 | Can antibiotic-induced changes in the composition of the hair follicle microbiome regulate human hair growth? | Bispo Lousada M, Edelkamp J, Lachnit T, Erdmann H, Paus R | Exp Dermatol. | read the full story | microbiome, hair growth, hair follicle |
2021 | UDP-GlcNAc-1-phosphotransferase is a clinically important regulator of human and mouse hair pigmentation | Tiede S, Hundt JE, Paus R | J Invest Dermatol. | read the full story | hair follicle, pigmentation, therapeutics, greying |
2021 | Quantitative mapping of human hair greying and reversal in relation to life stress | Rosenberg AM, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Kumar Soni R, Lacefield C, Tobin DJ, Paus R, Picard M | Elife. | read the full story | hair follicle, greying, pigmentation, stress |
2021 | Sensory re-innervation of human skin by human neural stem cell-derived peripheral neurons ex vivo | Chéret J, Piccini I, Gherardini J, Ponce L, Bertolini M, Paus R | J Invest Dermatol. | read the full story | model, skin re-innervation, itch irritation |
2021 | A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia? | Jozic I, Chéret J, Abujamra BA, Miteva M, Gherardini J, Paus R | Biomedicines. | read the full story | hair follicle, alopecia target, frontal fibrosing alopecia |
2021 | Pathobiology questions raised by telogen effluvium and trichodynia in COVID-19 patients | Di Landro A, Naldi L, Glaser E, Paus R, Tosti A | Exp Dermatol. | read the full story | Continuous Positive Airway Pressure, paracetamol, systemic steroids, anticoagulants, clinical manifestations |
2021 | Stress and Nasal Allergy: Corticotropin-Releasing Hormone Stimulates Mast Cell Degranulation and Proliferation in Human Nasal Mucosa | Yamanaka-Takaichi M, Mizukami Y, Sugawara K, Sunami K, Teranishi Y, Kira Y, Paus R, Tsuruta D | Int J Mol Sci. | read the full story | inflammation, stem cell factor, antalarmin, therapeutics |
2021 | Hair follicle chemosensation: TRPM5 signalling is required for anagen maintenance | Mardaryev A, van Lessen M, Alam M, Acosta FJ, Bíró T, Paus R | J Invest Dermatol. | read the full story | hair cycle, hair follicle, triphenylphosphine oxide, TRPM5 |
2021 | Beyond the NFAT Horizon: From Cyclosporine A-Induced Adverse Skin Effects to Novel Therapeutics | Hawkshaw NJ, Paus R | Trends Pharmacol Sci. | read the full story | hypertrichosis, human model systems, immunosuppressive therapy |
2021 | The biology of human hair greying | O'Sullivan JDB, Nicu C, Picard M, Chéret J, Bedogni B, Tobin DJ, Paus R | Biol Rev Camb Philos Soc. | read the full story | melanogenesis, bulge melanocyte stem cells, pigmentation, HFPU melanocyte survival |
2021 | Inhibition of Shh Signaling through MAPK Activation Controls Chemotherapy-Induced Alopecia | Haslam IS, Zhou G, Xie G, Teng X, Ao X, Yan Z, Smart E, Rutkowski D, Wierzbicka J, Zhou Y, Huang Z, Zhang Y, Farjo N, Farjo B, Paus R, Yue Z | J Invest Dermatol. | read the full story | antimitotic, apoptosis-promoting, MAPK-Shh axis |
2021 | Compartmentalised metabolic programmes in human anagen hair follicles: New targets to modulate epithelial stem cell behaviour, keratinocyte proliferation and hair follicle immune status? | Purba TS, Berriche L, Paus R | Exp Dermatol. | read the full story | Warburg effect, hair growth, immunological HF microenvironment |
2021 | Human epithelial stem cell survival within their niche requires "tonic" cannabinoid receptor 1-signaling - Lessons from the hair follicle | Sugawara K, Zákány N, Tiede S, Purba T, Harries M, Tsuruta D, Bíró T, Paus R | Exp Dermatol. | read the full story | endocannabinoid system, organ-cultured human HFs, human adult epithelial stem cell |
2021 | Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research | Stone RC, Aviv A, Paus R | J Invest Dermatol. | read the full story | pigmentary unit, chemotherapy-induced alopecia, telogen effluvium, androgenetic alopecia, cicatricial alopecia |
2021 | Dermal adipose tissue secretes HGF to promote human hair growth and pigmentation | Nicu C, O'Sullivan JDB, Ramos R, Timperi L, Lai T, Farjo N, Farjo B, Pople J, Bhogal R, Hardman JA, Plikus MV, Ansell DM, Paus R | J Invest Dermatol. | read the full story | hepatocyte growth factor, human HF-dWAT co-culture, human hair growth, pigmentation |
2021 | Shining a (blue) light on hair follicle chronobiology and photobiomodulation | Paus R | Exp Dermatol. | read the full story | hair follicles, metabolism, clock gene |
2021 | Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactions | Platt CI, Chéret J, Paus R | Arch Dermatol Res. | read the full story | microdissected scalp hair follicles, dermal papilla, 3-dimensional (3D) spheroids |
2021 | Translational Neuroendocrinology of Human Skin: Concepts and Perspectives | Ramot Y, Böhm M, Paus R | Trends Mol Med. | read the full story | neurohormones, neuropeptides, neurotransmitters, human skin physiology |
2020 | Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model | Gilhar A, Laufer Britva R, Keren A, Paus R | J Investig Dermatol | read the full story | alopecia areata, therapeutic effects, preclinical |
2020 | The Evolving Pathogenesis of Alopecia Areata: Major Open Questions | Paus R | J Investig Dermatol. | read the full story | autoimmune alopecia areata, atopic dermatitis, hair follicle |
2020 | Mouse models of atopic dermatitis: a critical reappraisal | Gilhar A, Reich K, Keren A, Kabashima K, Steinhoff M, Paus R | Exp Dermatol. | read the full story | atopic dermatitis, human skin xenotransplants, SCID mice |
2020 | Towards a renaissance of dermatoendocrinology: Selected current frontiers | Böhm M, Paus R | Exp Dermatol. | read the full story | |
2020 | Re-innervation of human skin by rat dorsal root ganglia permits to study interactions between sensory nerve fibers and native human dermal mast cells ex vivo | Chéret J, Ponce L, Le Gall-Ianotto C, Bertolini M, Paus R | Exp. Dermatol. | read the full story | human skin organ culture, functional sensory skin nerves, neurogenic skin inflammation |
2020 | Clues that mitochondria are involved in the hair cycle clock: MPZL3 regulates entry into and progression of murine hair follicle cycling | Nicu C, Wikramanayake TC, Paus R | Exp. Dermatol. | read the full story | intrinsic oscillator system, myelin protein zero- like 3, telogen‐to‐anagen transition |
2020 | Pro-inflammatory Vδ1 + T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles | Uchida Y, Gherardini J, Schulte-Mecklenbeck A, Alam M, Chéret J, Rossi A, Kanekura T, Gross CC, Arakawa A, Gilhar A, Bertolini M, Paus R | J Dermatol Sci. | read the full story | skin-resident γδT-cells, alopecia areata, hair follicle, innate immunity |
2020 | The Hair Follicle as an Interdisciplinary Model for Biomedical Research: An Eclectic Literature Synthesis | Haslam IS, Paus R | Bioessays | read the full story | human hair growth, regeneration, hair loss therapy, stem cell niches |
2020 | Translational Neuroendocrinology of Human Skin: Concepts and Perspectives | Ramot Y, Böhm M, Paus R | Trends Mol Med. | read the full story | neurohormones, inflammatory skin, neuropeptides |
2020 | The biology of human hair greying | O'Sullivan JDB, Nicu C, Picard M, Chéret J, Bedogni B, Tobin DJ, Paus R | Biol Rev Camb Philos Soc. | read the full story | anagen, hair follicle pigmentary unit, bulge melanocyte stem cells, |
2020 | A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo | Bertolini M, Chéret J, Pinto D, Hawkshaw N, Ponce L, Erdmann H, Jimenez F, Funk W, Paus R | Br J Dermatol. | read the full story | Wnt signalling, hair growth, hypertrichosis, catagen development |
2020 | Does dysfunctional autophagy contribute to immune privilege collapse and alopecia areata pathogenesis? | Hardman JA, Nicu C, Tai C, Harries M, Mironov A, Purba TS, Paus R | J Dermatol. Sci. | read the full story | autophagy, lysosomal degradation, ATG5, catagen, |
2020 | Exploring the human hair follicle microbiome | Lousada MB, Lachnit T, Edelkamp J, Rouillé T, Ajdic D, Uchida Y, Di Nardo A, Bosch TCG, Paus R | Br. J Dermatol. | read the full story | microbiota, human holobiont, antimicrobial peptides, microbial survival |
2020 | Inhibition of sonic hedgehog signaling via MAPK activation controls chemotherapy-induced alopecia | Haslam IS, Zhou G, Xie G, Teng X, Ao X, Yan Z, Smart E, Rutkowski D, Wierzbicka J, Zhou Y, Huang Z, Zhang Y, Farjo N, Farjo B, Paus R, Yue Z | J Invest Dermatol. | read the full story | clinical oncology, hair matrix keratinocytes, Shh signaling, hair follicle damage |
2020 | Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? | Paus R, Ramot Y, Kirsner RS, Tomic-Canic M | Exp. Dermatol. | read the full story | topical hormone therapy, thyroid hormone receptor, L‐thyroxine (T4), skin ulcers, telogen effluvium |
2020 | Hair follicle immune privilege and its collapse in alopecia areata | Bertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus R | Exp. Dermatol. | read the full story | MHC class, mast cells, CD4+, CD8+, NK cell, disease relapse |
2020 | Topical Odorant Application of the Specific Olfactory Receptor OR2AT4 Agonist, Sandalore ® , Improves Telogen Effluvium-Associated Parameters | Jimenez F, López E, Bertolini M, Alam M, Chéret J, Westgate G, Rinaldi F, Marzani B, Paus R. | J Cosmet Dermatol. | read the full story | OR2AT4 olfactory receptor, Sandalore®, claim substantiation, hair growth, hair treatment, telogen effluvium |
2020 | Vascular Endothelial Growth factor-A as a Promising Therapeutic Target for the Management of Psoriasis | Luengas-Martinez A, Hardman-Smart J, Paus R, Young HS. | Exp. Dermatol. | read the full story | angiogenic mediator, bevacizumab, personalised medicine, vascular endothelial growth factor A |
2020 | Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under "pathological" conditions ex vivo | Post H, Hundt JE, Zhang G, Depping R, Rose C, Langan EA, Paus R. | Arch Dermatol. Res | read the full story | hypoxia, skin organ culture, Wound healing, preclinical |
2020 | Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? | Paus R, Ramot Y, Kirsner RS, Tomic-Canic M | Exp Dermatol. | read the full story | nuclear hormone receptors, wound healing, hair growth, telogen effluvium, triiodothyronine |
2020 | Does mitochondrial dysfunction of hair follicle epithelial stem cells play a role in the pathobiology of lichen planopilaris? | Hardman-Smart JA, Purba TS, Panicker S, Farjo B, Farjo N, Harries MJ, Paus R. | Br J Dermatol. | read the full story | T- cell mediated interferon-γ, immune privilege, |
2020 | Vascular endothelial growth factor blockade induces dermal endothelial cell apoptosis in a clinically relevant skin organ culture model | Luengas-Martinez A, Hardman-Smart J, Rutkowski D, Purba TS, Paus R, Young HS | Skin Pharmacol Physiol | read the full story | anti-VEGF, endothelial cell apoptosis, human skin ex vivo, microvascular network, Psoriasis |
2020 | Non‐neuronal kappa‐opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex vivo | Chéret J, Gherardini J, Soeberdt M, Hundt JE, Abels C, Bertolini M, Paus R | J Dermatol | read the full story | neurogenic inflammation, human skin organ culture, keratinocyte apoptosis, inflammatory dermatoses |
2020 | Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis | Oláh A, Alam M, Chéret J, Kis NG, Hegyi Z, Szöllősi AG, Vidali S, Bíró T, Paus R | Exp Dermatol | read the full story | keratinocyte mitochondrial activity, cannabinoid receptor 1, organ-cultured full-thickness human skin, ROS production, skin aging, photodamage |
2020 | Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 Skewing | Del Duca E, Ruano Ruiz J, Pavel AB, Sanyal RD, Song T, Gay-Mimbrera J, Zhang N, Estrada YD, Peng X, Renert-Yuval Y, Phelps RG, Paus R, Krueger JG, Guttman-Yassky E. | Br J Dermatol | read the full story | lesional, nonlesional scalp biopsies, stem cells, follicular damage, JAK/STAT-targeting treatments |
2020 | Hair(y) matters in melanoma biology | Barbara Bedogni, Ralf Paus | Trends in Molecular Medicine | read the full story | metastatic melanoma, melanocytes, immune-privileged microenvironment, stem cells, melanoma prevention strategy |
2020 | New effects of caffeine on CRH-induced stress along the intrafollicular classical HPA-axis (CRH-R1/2, IP3 -R, ACTH, MC-R2) and the neurogenic non-HPA-axis (substance P, p75NTR and TrkA) in ex vivo human male androgenetic scalp hair follicles. | Fischer TW, Bergmann A, Kruse N, Kleszczynski K, Skobowiat C, Slominski AT, Paus R | Br J Dermatol | read the full story | human hair, androgenetic alopecia, stress-induced hair loss, hair organ culture model, caffeine |
2020 | An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytes | Alam M, Bertolini M, Gherardini J, Keren A, Ponce L, Chéret J, Alenfall J, Dunér P, Nilsson AH, Gilhar A, Paus R | Br J Dermatol | read the full story | human scalp skin xenotransplant, human hair follicle organ culture, hypertrichosis, hirsutism, hair growth |
2020 | Adenosine promotes human hair growth and inhibits catagen transition in vitro - role of the outer sheath keratinocytes. | Lisztes E, Toth BI, Bertolini M, Szabo IL, Zakany N, Olah A, Szollosi AG, Paus R, Biro T. | J Invest Dermatol | read the full story | hair follicle, ex vivo, organ culture, co-immunolabeling, G-protein, hair growth |
2020 | Toward predicting the spatio-temporal dynamics of alopecia areata lesions using partial differential equation analysis. | Atanaska Dobreva, Ralf Paus, N. G. Cogan | Bull Math Biol | read the full story | autoimmune disease, alopecia areata, partial differential equations, humanized mouse model |
2020 | Fluoxetine promotes human hair follicle pigmentation ex vivo: Serotonin re-uptake inhibition as a new anti-greying strategy? | Cheret J, Gherardini J, Bertolini M, Paus R. | Br J Dermatol | read the full story | hair follicle, ex vivo, organ culture, quantitative Masson-Fontana histomorphometry, serotonin receptor, melanotropic neurohormone |
2020 | Do hair follicles operate as primitive, multifocal kidney-like excretory (mini-)organs? | Carré JL, Suzuki T, Paus R | Exp Dermatol | read the full story | trichocytes, hair shafts, classical nephrological therapy, erythropoietin synthesis |
2020 | Neuroendocrinology and neurobiology of sebaceous gland. | Clayton RW, Langan EA, Ansell DM, de Vos IJHM, Göbel K, Schneider MR, Picardo M, Lim X, van Steensel MAM, Paus R | Biol Rev Camb Philos Soc | read the full story | nervous system, pituitary control, sebaceous glands, homeostasis |
2020 | Phytocannabinoid(-)-Cannabidiol operates as a complex, differential modular of human hair growth: Anti-inflammatory sub-micromolar versus hair growth inhibitory micromolar effects. | Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro T | J Invest Dermatol | read the full story | hair follicle, ex vivo organ culture, toll-like receptor, hair morphology |
2020 | Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata. | Laufer BR, Keren A, Paus R, Gilhar A. | Br J Dermatol | read the full story | hair loss, hair follicle, phosphodiesterase inhibitor, therapeutics |
2020 | Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during subtance P-mediated neurogenic inflammation ex vivo. | Gherardini J, Uchida Y, Hardman JA, Cheret J, Mace K, Bertolini M, Paus R | PLoS One | read the full story | macrophages, full-thickness skin organ culture, immunohistochemistry, neuroinflammatory stimulus |
2020 | Schwann cells as underestimated, major players in human skin physiology and pathology. | Bray ER, Cheret J, Yosipovitch G, Paus R. | Exp Dermatol | read the full story | axon regeneration, wound healing, atopic dermatitis, psoriasis |
2020 | Theophylline exerts complex anti-aging and anti-cytotoxicity effects in human skin ex vivo. | Bertolini M, Ramot Y, Gherardini J, Heinen G, Cheret J, Welss T, Giesen M, Funk W, Paus R. | Int J Cosmet Sci | read the full story | full thickness skin, organ culture, ex vivo, phosphodiesterase inhibitor, metallothionein‐1, collagen, skin‐protective properties |
2019 | JAK inhibitors and alopecia areata. | Gilhar A, Keren A, Paus R. | Lancet | read the full story | systemic therapy, cytokines, autoimmune disease |
2019 | Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine. | Gherardini J, Wegner J, Cheret J, Ghatak S, Lehmann J, Alam M, Jimenez F, Funk W, Bohm M, Botchkareva NV, Ward C, Paus R, Bertolini M. | Int J Cosmet Sci | read the full story | ex vivo, organ culture, UV exposure, keratinocyte apoptosis, photoprotectants, clinical relevance |
2019 | Nestin(+) progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo. | Liao T, Lehmann J, Sternstein S, Yay A, Zhang G, Matthiessen AE, Schumann S, Siemers F, Kruse C, Hundt JE, Langan EA, Tiede S, Paus R. | Arch Dermatol Res | read the full story | skin punch biopsies, ex vivo, wound healing model, pre-clinical, regenerative medicine, chronic skin ulceration |
2019 | Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle? | Nicu C, Hardman JA, Pople J, Paus R. | Exp Dermatol | read the full story | hair follicle, transmission electron microscopy, anagen‐catagen transition, lipogenesis, hair cycle |
2019 | Assessment of Quality of Life and Treatment Outcomes of Patients with persistent postchemotherapy alopecia. | Freites-Martinez A, Chan D, Sibaud V, Shapiro J, Fabbrocini G, Tosti A, Cho J, Goldfarb S, Modi S, Gajria D, Norton L, Paus R, Cigler T, Lacouture ME. | JAMA Dermatol | read the full story | persistent chemotherapy-induced alopecia, clinical study, hair loss, patinets, dermatologic therapy |
2019 | Hair growth control by innate immunocytes: Perifollicular macrophages revisited. | Muneeb F, Hardman JA, Paus R. | Exp Dermatol | read the full story | hair matrix, hair cycle stage, hair follicle morphogenesis, Wnt signalling, clinically relevant |
2019 | Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo. | Zhang GY, Langan EA, Meier NT, Funk W, Siemers F, Paus R. | PLoS One | read the full story | full thickness human skin, wound healing organ culture model, quantitative immunohistomorphometry, pre-clinical testing, keratin expression, energy metabolism |
2019 | Distinct patterns of hair graft Survival After Transplantation into 2 Nonhealing Ulcers: Is Location Everything? | Alam M, Cooley J, Plotczyk M, Martinez-Martin MS, Izeta A, Paus R, Jimenez F. | Dermatol Surg | read the full story | hair follicles, scar formation, hair growth, wound healing, human skin |
2019 | Image Gallery: Optical coherence tomography for intravital human hair follicle analyses ex vivo. | Lehmann J, Kemper B, Barroso Pena A, Schnekenburger J, Paus R, Bertolini M, Cheret J. | Br J Dermatol | read the full story | label‐free, high‐resolution, anatomical details, ex vivo, organ culture, hair matrix |
2019 | Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis. | Leon A, Rosen JD, Hashimoto T, Fostini AC, Paus R, Yosipovitch G. | Exp Dermatol | read the full story | hair follicle, mast cells, neurogenic inflammation, psoriatic scalp itch, immunogenic inflammation |
2019 | Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis. | Clayton RW, Gobel K, Niessen CM, Paus R, van Steensel MAM, Lim X. | Br J Dermatol | read the full story | genetic mouse models, mammalian skin, acne vulgaris, comedones, acne pathogenesis |
2019 | Hair disorders in patients with cancer. | Freites-Martinez A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME. | J Am Acad Dermatol | read the full story | chemotherapy induced alopecia, hair repigmentation, immunotherapies, oncology patients |
2019 | Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias. | Harries M, Imanishi H, Paus R. | J Am Acad Dermatol | read the full story | laser capture microdissection, microarray analysis, hair follicle, immune privilege collapse, follicular inflammation |
2019 | TRPV4 is expressed in human hair follicles and inhibits hair growth in vitro. | Szabo IL, Herczeg-Lisztes E, Szegedi A, Nemes B, Paus R, Biro T, Szollosi AG. | J Invest Dermatol | read the full story | calcium permeable, microflorimetric Ca2+ measurement, outer root sheath keratinocytes, peripheral sensory nerves |
2019 | Growth hormone operates as a neuroendocrine regulator of human hair growth ex vivo. | Alam M, Below DA, Cheret J, Langan EA, Bertolini M, Jimenez F, Paus R. | J Invest Dermatol | read the full story | human hair follicle, ex vivo, organ culture, mini-organ, neuropeptides, pigmentation |
2019 | Alopecia areata patients show deficiency of FOXP3+CD39+ T regulartory cells and clonotypic restriction of Treg TCRß-chain, which highlights the immunopathological aspect of disease. | Hamed FN, Astrand A, Bertolini M, Rossi A, Maleki Dizaji A, Messanger AG, Mc Donagh AJG, Tazi-Ahnini R. | PloS One | read the full story | flow cytometry, next Generation Sequencing, hair loss, Treg clonotypes, autoimmune reaction |
2019 | Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation. | Hawkshaw NJ, Hardman JA, Alam M, Jimenez F, Paus R. | Br J Dermatol | read the full story | in situ hybridization, human telogen, scalp hair follicle sections, hair biology |
2019 | Inhibition of ATP binding cassette transporter B1 sensitizes human hair follicles to chemotherapy-induced damage. | Smart E, Farjo N, Farjo B, Haslam IS, Paus R. | J Dermatol Sci | read the full story | quantitative immunohistomorphometry, 4-hydroxycyclophosphamide, anthracycline doxorubicin, ex vivo, proliferation, apoptosis |
2019 | The Phytocannabinoid (-)-Cannabidiol operates as a complex, differential modulator of human hair qrowth: anti-inflammatory submicromolar versus hair growth inhibitory micromolar effects. | Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro T. | J Invest Dermatol | read the full story | hair follicle, organ culture, hair shaft, hair cycle, hair matrix keratinocytes |
2019 | Seborrheic dermatitis-Looking beyond Malassezia. | Wikramanayake TC, Borda LJ, Miteva M, Paus R. | Exp Dermatol | read the full story | chronic, relapsing inflammatory, skin disease, Mpzl3 knockout mice, epidermal barrier, sebaceous activity |
2019 | CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia. | Purba TS, Ng'andu K, Brunken L, Smart E, Mitchell E, Hassan N, O'Brien A, Mellor C, Jackson J, Shahmalak A, Paus R. | EMBO Mol Med | read the full story | hair follicle, organ culture, epithelial bulge stem cell analysis, chemotherapy, paclitaxel, docetaxel, mitotic defects |
2019 | PPAR-Y signalling as a key mediator of human hair follicle physiology and pathology. | Ramot Y, Bertolini M, Bobolijava M, Uchida Y, Paus R. | Exp. Dermatol | read the full story | hair follicle development, scarring alopecia, epithelial-mesenchymal transition, androgenetic alopecia |
2019 | Precilinal evidence that PPARγ- modulator, N-Acetyl-GED-0507-34-Levo, may protect human hair follicle epithelial stem cells against lichen planopilaris -associated damage. | Cheret J, Piccini I, Hardman-Smart J, Ghatak S, Alam M, Lehmann J, Jimenez F, Erdmann H, Poblet E, Botchkareva N, Paus R, Bertolini M. | J Eur Acad Dermatol Vernereol | read the full story | hair follicle, ex vivo, organ culture, immunohistochemistry, NAGED, hair loss, lichen planopilaris |
2019 | Mineralocorticoid receptor antagonists stimulate human hair growth ex vivo. | Hundt JE, Sass S, Funk W, Biro T, Farman N, Langan EA, Paus R. | Skin Pharmacol Physiol | read the full story | hair follicle, ex vivo, organ culture, glucocorticoid, hair cycle |
2019 | Y-27632 preserves epidermal intregity in a human skin-organ culture (h-SOC) system by regulating AKT and ERK signalling pathways. | Zang X, Qin J, Xie Z, Liu C, Su Y, Chen Z, Zho Q, Ma C, Liu G, Paus R, Guo J, Wu X. | J Dermatol Sci | read the full story | human breast skin, organ culture, ex vivo, epidermal cell proliferation, immunofluorescence staining, ROCK inhibitor, epidermal architecture |
2019 | Frontiers in alopecia areata pathobiology research. | Gilhar A, Britva RL, Keren A, Paus R. | J Allergy Clin Immunol | read the full story | humanized mouse model, autoantigens, regulatory T cells, immune privilege |
2019 | Human perifollicular macrophages undergo apoptosis, express Wnt ligands and switch their polarization during catagen. | Hardman JA, Muneeb F, Pople J, Bhogal R, Shahmalak A, Paus R. | J Invest Dermatol | read the full story | human hair follicle, ex vivo, organ culture, hair cycle, inflammatory hair disease |
2019 | Model-based approach to the design of pharmaceutical roller-compaction processes. | Toson P, Lopes DG, Paus R, Kumar A, Geens J, Stibale S, Quodbach J, Kleinebudde P, Hsiao WK, Khinast J. | Int J Pharm | read the full story | mathematical model, in-silico, ibuprofen formulations, iterative calibration |
2018 | Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-alpha administration differ during wound repair and regeneration. | Abarca-Buis RF, Martinez-Jimenez A, Vera-Gomez E, Contreras-Figueroa ME, Garciadiego-Cazares D, Paus R, Robles-Tenorio A, Krotzsch E. | Differentiation | read the full story | ear punch wound mouse model, histology analysis, fibrotic scarring, epidermal apoptosis |
2018 | Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management. | Paus R, Bulfone-Paus S, Bertolini M. | J Investig Dermatol Symp Proc | read the full story | hair bulb, pharmacological manipulation, Immune privilege collapse-related autoimmune diseases |
2018 | An efficient method for eccrine gland isolation from human scalp. | Jimenez F, Alam M, Hernandez I, Poblet E, Hardman JA, Paus R. | Exp Dermatol | read the full story | hair graft harvesting method, calp follicular unit grafts, microdissection, methylene blue staining |
2018 | NF-kappaB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types. | Krieger K, Millar SE, Mikuda N, Krahn I, Kloepper JE, Bertolini M, Scheidereit C, Paus R, Schmidt-Ullrich R. | J Invest Dermatol | read the full story | humanized mouse model, hair cycle analysis, histological techniques, anagen induction, telogen−anagen transition |
2018 | Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue. | Poblet E, Jimenez F, Escario-Travesedo E, Hardman JA, Hernandez-Hernandez I, Agudo-Mena JL, Cabrera-Galvan JJ, Nicu C, Paus R. | Br J Dermatol | read the full story | 3D reconstruction, human scalp, follicular unit transplant grafts, scalp strip ex vivo, human skin adnexa |
2018 | Epithelial-to-mesenchymal stem cell transition in a human organ: Lessons from lichen planopilaris. | Imanishi H, Ansell DM, Cheret J, Harries M, Bertolini M, Sepp N, Biro T, Poblet E, Jimenez F, Hardman J, Panicker SP, Ward CM, Paus R. | J Invest Dermatol | read the full story | hair follicle, ex vivo organ culture, immunohistochemistry, transmission electron microscopy, preclinical assay |
2018 | Prolactin as a candidate sebotrop(h)ic hormone? | Langan EA, Hinde E, Paus R. | Exp Dermatol | read the full story | human dermatoses, sebaceous gland, therapeutic strategies, cutaneous ageing |
2018 | A guide to studying human dermal adipocytes in situ. | Nicu, C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. | Exp Dermatol | read the full story | quantitative immunohistomorphometry, dermal white adipose tissue, in situ hybridization, neuroendocrinology |
2018 | Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture. | Parodi C, Hardman JA, Allavena G, Marotta R, Catelani T, Bertolini M, Paus R, Grimaldi B. | PLoS Biol | read the full story | cell culture, quantitative immunohistomorphometry, ex vivo, knockdown, preclinical research model |
2018 | Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg total deletion. | Sardella C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F. | J Invest Dermatol | read the full story | humanized mouse model, skin grafts, in vivo, gene expression, adipose tissue-mediated signals |
2018 | Melatonin: A cutaneous perspective on its production, metabolism, and functions. | Slominski AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ, Paus R. | J Invest Dermatol | read the full story | hair follicle, photo-protection, anti-cancer activity, wound healing, pigmentation, inflammatory dermatoses |
2018 | Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal. | Foster AR, Nicu C, Schneider MR, Hinde E, Paus R. | Arch Dermatol Res | read the full story | in vivo BODIPY, immunohistomorphometry, wound healing, adipocyte hypertrophy |
2018 | Lichen planopilaris and frontal fibrosing alopecia as model epithelial stem cell diseases. | Harries MJ, Jimenez F, Izeta A, Hardman J, Panicker SP, Poblet E, Paus R. | Trends Mol Med | read the full story | hair follicle, PPAR-γ, epithelial-mesenchymal transition, immune-privilege |
2018 | Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles. | Hawkshaw NJ, Hardman JA, Haslam IS, Shahmalak A, Gilhar A, Lim X, Paus R. | PLoS Biol | read the full story | hair follicle, ex vivo organ culture, Quantitative immunohistomorphometry, bioinformatics, immunosuppressant, therapeutic strategy |
2018 | How UV light touches the brain and endocrine system through skin, and why. | Slominski AT, Zmijewski MA, Plonka PM, Szaflarski JP, Paus R. | Endocrinology | read the full story | environmental factors, UV radiation, body homeostasis, neuro-endocrine system |
2018 | Image Gallery: Intravital visualization of the dynamic changes in human hair follicle cycling. | Alam M, Hernandez I, Paus R, Jimenez F. | Br J Dermatol | read the full story | anagen, catagen, telogen, methylene blue staining, hair cycle stage |
2018 | Topically applied nicotinamide inhibits human hair follicle growth ex vivo. | Haslam IS, Hardman JA, Paus R. | J Invest Dermatol | read the full story | organ culture, microdissected human scalp hair follicles, hair growth inhibitor, catagen, mast cells |
2018 | Re-investigating the basement membrane zone of psoriatic epidermal lesions: Is laminin-511 a new player in psoriasis pathogenesis? | Natsumi A, Sugawara K, Yasumizu M, Mizukami Y, Sano S, Morita A, Paus R, Tsuruta D. | J Histochem Cytochem | read the full story | skin tumorectomy, immunohistochemistry, transmission electron microscopy, laminin-511, keratinocyte growth/death |
2018 | Cover Image: Neuroendocrine treatment of inherited keratin disorders by cannabinoids? | Ramot Y, Olah A, Paus R. | Br J Dermatol | read the full story | uman skin organ culture, ex vivo, epidermolytic ichthyosis, keratin disorders, cannabinoid signalling |
2018 | iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata. | Ghraieb A, Keren A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A. | J Autoimmun | read the full story | humanized mouse model, xenotransplants, lymphocytes, therapeutic potential |
2018 | Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin. | Keren A, Shemer A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A. | J Allergy Clin Immunol | read the full story | humanized mouse model, sublethal irradiation, immunohistochemical analysis, cytokine analyses, psoriatic lesions |
2018 | Peroxisome Proliferator-Activated Receptor-gamma-Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium. | Ramot Y, Alam M, Olah A, Biro T, Ponce L, Cheret J, Bertolini M, Paus R. | J Invest Dermatol | read the full story | ex vivo organ culture, gene expression, N-Acetyl-GED, mitochondrial function, ORS keratinocytes |
2018 | Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling. | Dobreva, A, Paus R, Cogan NG. | Math Med Biol | read the full story | mathematical modelling, anagen phase interruption, therapeutic targets |
2018 | Visualization of global RNA synthesis in a human (mini-) organ in situ by click chemistry. | Purba TS, Marsh J, Ng'andu K, Kurinna S, Paus R. | Biotechniques | read the full story | human hair follicle, ex vivo organ culture, in situ RNA synthesis, 5-ethynyl uridine |
2018 | Bridging the "Dead hair"-"live follicle" divide in applied hair research. | Bertolini M, Botchkareva N, Westgate G, Ward C, Cornwell P, Paus R. | J Cosmet Sci | read the full story | synopsis, mini-organ, hair shaft structure |
2018 | Olfactory receptor OR2AT4 regulates human hair growth. | Cheret J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M, Hatt H, Paus R. | Nat Commun | read the full story | ex vivo, organ culture, knockdown, histological analysis, genome-micro array analysis, sandalore, synthetic sandalwood, hair growth, hair loss therapy |
2018 | A technique for more precise distinction between catagen and telogen human hair follicles ex vivo. | Hernandez I, Alam M, Platt C, Hardman J, Smart E, Poblet E, Bertolini M, Paus R, Jimenez F. | J Am Acad Dermatol | read the full story | ex vivo organ culture, hair cycle stage, macroscopic analysis |
2018 | Transcriptional programming of normal and inflamed human epidermis at single-cell resolution. | Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. | Cell Rep | read the full story | computational analysis, single-cell RNAseq, keratinocyte |
2018 | Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P-induced human mast cell activation and degranulation in the hair follicle. | Jadkauskaite L, Bahri R, Farjo N, Farjo B, Jenkins G, Bhogal R, Haslam I, Bulfone-Paus S, Paus R. | J Allergy Clin Immunol | read the full story | ex vivo organ culture, immunohistochemistry, mast cells degranulation and activity assay, neuropeptide, androgenetic alopecia, alopecia areata |
2018 | Bi-allelic mutations in LSS, encoding lanosterol synthase, cause autosomal-recessive hypotrichosis simplex. | Romano, MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmuller J, Nurnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lutjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC. | Am J Hum Genet | read the full story | whole-exsome sequencing, alopecia, cholesterol biosynthetic pathway, lanosterol synthase |
2018 | The renaissance of human skin organ culture: A critical reappraisal. | Zhou L, Zhang X, Paus R, Lu Z. | Differentiation | read the full story | ex vivo, morphological analyses, gene silencing, assays |
2018 | Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding? | Langan EA, Fink T, Paus R. | Arch Dermatol Res | read the full story | ex vivo, human skin organ culture, PRL receptor antagonists, keratinocyte differentiation |
2018 | Retinoic acid co-treatment aggravates severity of dioxin-induced skin lesions in hairless mice via induction of inflammatory response. | Rudyak SG, Usakin LA, Tverye EA, Orekhov AS, Belushkina NN, Paus R, Paltsev MA, Panteleyev AA. | Biochem Biophys Res Commun | read the full story | humanized mouse model, halogenated polyaromatic hydrocarbons, skin pathologies, keratinocyte |
2017 | Oxidative damage control in a human (mini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition. | Haslam IS, Jadkauskaite L, Szabo IL, Staege S, Hesebeck-Brinckmann J, Jenkins G, Bhogal RK, Lim FL, Farjo N, Farjo B, Biro T, Schafer M, Paus R. | J Invest Dermatol | read the full story | human hair follicle, organ culture, ex vivo, quantitative immunofluorescence, ROS, keratinocytes |
2017 | Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. | Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nothen MM. | Nat Commun | read the full story | geno-wide analysis, meta-analysis, hair follicle cycling, therapeutics |
2017 | Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology. | Jumper N, Hodgkinson T, Paus R, Bayat A. | PLoS One | read the full story | site-specific in situ microdissection, transcriptome array analysis, 2D cell culture, TGFβ-mediated signaling |
2017 | Enhanced neurogenic biomarker expression and reinnervation in human acute skin wounds treated by electrical stimulation. | Sebastian A, Volk SW, Halai P, Colthurst J, Paus R, Bayat A. | J Invest Dermatol | read the full story | Human punch biopsy, wound healing, microarray analysis, in vivo repair, neuroblastoma |
2017 | Cover Image: Are melanocyte-associated peptides the elusive autoantigens in alopecia areata? | Bertolini M, Rossi A, Paus R. | Br J Dermatol | read the full story | hair follicle, hair matrix melanocytes, mast cells, autoantigens, melanogenesis |
2017 | Regulatory T cells in skin facilitate epithelial stem cell differentiation. | Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. | Cell | read the full story | immune-profiling, immunofluorescent microscopy, in vivo mouse model, skin inflammation, telogen-anagen transition, Jagged 1, hair regeneration, alopecia areata |
2017 | Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1beta-mediated signaling. | Stojadinovic O, Wikramanayake TC, Villasante Fricke AC, Yin NC, Liang L, Hinde E, Escandon J, Tomic-Canic M, Ansell DM, Paus R, Jimenez JJ. | Heliyon | read the full story | Keywords: incisional wound induction, histological analysis, cytokine injection, Gene expression profiling, hair cycle, IL-1β signaling |
2017 | Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. | Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmuller J, Stander S, Luger T, Paus R, Cheret J, Hatt H. | Exp Dermatol | read the full story | human keratinocytes culture, cAMP‐dependent pathway, skin diseases, wound repair |
2017 | Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond? | Jadkauskaite L, Coulombe PA, Schafer M, Dinkova-Kostova AT, Paus R, Haslam IS. | Bioessays | read the full story | redox homeostasis, NRF2 activation, hair follicle pathologies |
2017 | E-cadherin-mediated cell contact controls the epidermal damage response in radiation dermatitis. | Xie G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H, Ramot Y, Paus R, Yue Z. | J Invest Dermatol | read the full story | human skin biopsy, footpad mouse model, in vivo rescue, epidermal keratinocytes, radiotherapy |
2017 | Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix. | Purba TS, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, Ceballos L, Gandarillas A, Paus R | Eur J Cell Biol | read the full story | human hair follicle, ex vivo organ culture, in situ hybridisation, CIP/KIP proteins, hair bulb growth |
2017 | T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle. | Oelert T, Gilhar A, Paus R. | Exp Dermatol | read the full story | hair follicle, immune privilege collapse, CD4+ regulatory T cells, alopecia areata |
2017 | A role for neuregulin-1 in promoting keloid fibroblast migration via ErbB2-mediated signaling. | Jumper N, Hodgkinson T, Paus R, Bayat A. | Acta Derm Venereol | read the full story | laser capture microdissection, in situ gene expression profiling, NRG1/ErbB2/Src/PTK2 signaling pathway, fibroproliferative tumour |
2017 | Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2. | Purba TS, Peake M, Farjo B, Farjo N, Bhogal RK, Jenkins G, Paus R. | Sci Rep | read the full story | ex vivo, hair follicle organ culture, Immunofluorescence, Quantitative immunohistomorphometry, epithelial stem cells |
2016 | Hair follicle bulge stem cells appear dispensable for the acute phase of wound re-epithelialization. | Garcin CL, Ansell DM, Headon DJ, Paus R, Hardman MJ. | Stem Cells | read the full story | wound healing, transgenic mice, in vivo |
2016 | An innovative approach to dissecting keloid disease leading to identification of the retinoic acid pathway as a potential therapeutic target. | Jumper N, Paus R, Bayat A. | Plast Reconstr Surg Glob Open | read the full story | skin biopsies, laser capture microdissection, epidermis |
2016 | A Guide to studying human hair follicle cycling in vivo. | Oh JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS, Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV. | J Invest Dermatol | read the full story | pre-clinical, xenograft, immuno-histochemistry |
2016 | Lhx2 is a direct NF-kappaB target gene that promotes primary hair follicle placode down-growth. | Tomann P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R. | Development | read the full story | gene expression, transcriptome, embryos, cell migration |
2016 | Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice. | Dahlhoff M, Camera E, Schafer M, Emrich D, Riethmacher D, Foster A, Paus R, Schneider MR. | Development | read the full story | gene targeting, mouse line, in vivo, meibomian gland disease |
2016 | p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a rat model of radiation dermatitis. | Liao C, Xie G, Zhu L, Chen X, Li X, Lu H, Xu B, Ramot Y, Paus R, Yue Z. | J Invest Dermatol | read the full story | chip analysis, in vivo, therapeutic targeting, dermatoses |
2016 | Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse. | Bertolini M, Pretzlaff M, Sulk M, Bahr M, Gherardini J, Uchida Y, Reibelt M, Kinori M, Rossi A, Biro T, Paus R. | Br J Dermatol | read the full story | hair follicle organ culture, immuno‐histomorphometry, autoimmune disorder |
2016 | A primer for studying cell cycle dynamics of the human hair follicle. | Purba TS, Brunken L, Hawkshaw NJ, Peake M, Hardman J, Paus R. | Exp Dermatol | read the full story | immuno-labelling, cell cycle, proliferation, apoptosis |
2016 | Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue. | Bagabir RA, Syed F, Shenjere P, Paus R, Bayat A. | J Invest Dermatol | read the full story | molecular diagnostic, biomarker, immunohistochemistry, dermal scarring |
2016 | Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies. | Gilhar A, Schrum AG, Etzioni A, Waldmann H, Paus R. | Autoimmun Rev | read the full story | xenografts, transplantation, SCID mice, therapeutic strategies |
2016 | The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease. | Jumper N, Hodgkinson T, Arscott G, Har-Shai Y, Paus R, Bayat A. | J Invest Dermatol | read the full story | laser capture microdissection, microarray, luciferase assay, metabolism |
2016 | The gut-skin axis in health and disease: A paradigm with therapeutic implications. | O'Neill CA, Monteleone G, McLaughlin JT, Paus R. | Bioessays | read the full story | microbiota, signaling pathways, skin co‐morbidities |
2016 | The thyroid hormone analogue KB2115 (Eprotirome) prolongs human hair growth (anagen) ex vivo. | Olah A, Gherardini J, Bertolini M, Cheret J, Ponce L, Kloepper J, Biro T, Soeberdt M, Abels C, Paus R. | J Invest Dermatol | read the full story | human scalp hair follicle, organ culture, hair cycle, translational human hair research |
2016 | Exploring the "brain-skin connection": Leads and lessons from the hair follicle. | Paus R. | Curr Res Transl Med | read the full story | human hair follicle, organ culture, neuro-hormone, skin epithelium, Melatonin |
2016 | Biology of the eyelash hair follicle: an enigma in plain sight. | Paus R, Burgoa I, Platt CI, Griffiths T, Poblet E, Izeta A. | Br J Dermatol | read the full story | mini-organ culture, greying, cosmetic manipulation |
2016 | Mutations in TSPEAR, encoding a regulator of notch signaling, affect tooth and hair follicle morphogenesis. | Peled A, Sarig O, Samuelov L, Bertolini M, Ziv L, Weissglas-Volkov D, Eskin-Schwartz M, Adase CA, Malchin N, Bochner R, Fainberg G, Goldberg I, Sugawara K, Baniel A, Tsuruta D, Luxenburg C, Adir N, Duverger O, Morasso M, Shalev S, Gallo RL, Shomron N, Paus R, Sprecher E. | PLoS Genet | read the full story | siRNA, NOTCH1 reporter assay, knockdown in mice hair follicles, organ cultures, apoptosis, ectodermal dysplasias |
2016 | Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit? | Poblet E, Jimenez-Acosta F, Hardman JA, Escario E, Paus R. | Exp Dermatol | read the full story | 3D imaging, scalp follicular units, skin appendages |
2016 | Thyroid hormones enhance mitochondrial function in human epidermis. | Vidali S, Cheret J, Giesen M, Haeger S, Alam M, Watson REB, Langton AK, Klinger M, Knuever J, Funk W, Kofler B, Paus R. | J Invest Dermatol | read the full story | Human skin organ culture, ex vivo, immunohistochemistry, Transmission electron microscopy, In situ zymography, skin aging, mitochondrial function |
2016 | Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis. | Fleger-Weckmann A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. | Matrix Biol | read the full story | Hair follicle formation, histological analysis, electron microscopy, mouse model, hair shaft differentiation, basement membrane |