Thanks to our great network of collaborating dermatologists and surgeons, we have ample access to tissue specimens of scalp skin from healthy subjects and patients affected by hair follicle disorders. Employing our extensive portfolio of techniques, we use these human skin specimen for the identification and characterization of new therapeutic targets. In addition, we use human primary cells, ex vivo organ culture of human hair follicles and human full thickness skin, and humanized mouse in vivo models to validate new targets for hair disorders, as well as investigating mechanisms of action, and effects of compounds/formulations/drugs (also via topical application) for hair disorders management.
Our expertise also includes:
- Alopecia areata
- Lichen planopilaris
- Frontal fibrosing alopecia
- Female pattern alopecia
- Male pattern alopecia (Androgenetic alopecia)
- Chemotherapy induced alopecia
- Genetic hair disorders
- Acne Inversa (Hidradenitis Supprativa)
A wide range of parameters are available, and customized experiments can be designed to meet the needs of our customers.
We also have available the human lesional skin organ cultures to test the efficacy of compounds ex vivo (an alternative to animal experiments).
Piccini et al., 2021, Laufer Britva et al., 2021, Uchida et al., 2021, Gilhar et al., 2020, Uchida et al., 2020, Hardman et al., 2020, Haslam et al., 2020, Bertolini et al., 2020, Fischer et al., 2020, Chéret et al., 2020, Purba et al., 2020, Smart et al., 2020, Laufer et al., 2020, Cheret et al., 2019, Tafazzoli et al., 2018, Ghraieb et al.,2018, Imanishi et al., 2018, Peled et al., 2016, Bertolini et al., 2016, Keren et al., 2015, Bertolini et al., 2014
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