Adiponectin is a hormone that is primarily secreted by white adipose tissue. High levels of adiponectin in the blood circulation are observed in diseases including fibrosis and diabetes. However, it positively influences skin function and it has anti-aging effects on skin cells. Interestingly, adiponectin exists in different forms, as globular […]
Adiponectin negatively regulates pigmentation, Wnt/β‑catenin and HGF/c‑Met signalling within human scalp hair follicles ex vivo Carina Nicu, Jennifer Jackson, Asim Shahmalak, Jenny pople, David Ansell, Ralf Paus Arch dermatol Res, 2021 A compelling study comprising “the effect of the hormone adiponectin on human hair follicle function and pigmentation” was recently […]
We are proud to announce Monasterium Laboratory has been selected as award winner by the Biotechnology Heritage Awards 2022 for the category “Most Innovative Research Business – Germany.” The award has been given out after being selected by an independent panel of judges and dedicated researchers who analyzed our work […]
Hair follicles (HFs) in the growth stage (anagen) exhibit a great degree of cell division. On top of this, there is a high rate of protein synthesis to support keratinization of the growing hair fiber. As a result, the HF must have access to an ample supply of adequate nutrients, […]
Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase Karazyna Figlak, Greg Williams, Ralf Paus, Marta Bertolini, Michael P. Philpott Br J Dermatol, 2021 Hair follicles (HFs) in the growth stage (anagen) exhibit a great degree of cell division. On top of this, there […]
A common side-effect of cancer chemotherapy is hair loss, termed chemotherapy-induced alopecia (CIA). CIA is perhaps the most visual of the side-effects of chemotherapy and is highly distressing for patients who experience it. In most patients, this effect is temporary and the lost hair will regrow within 3 months. In […]
PPARγ signaling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transition Ilaria Piccini, Lars Brunken, Jérémy Chéret , Sushmita Ghatak, Yamus Ramot, Majid Alam , Talveen S Purba , Jonathan Hardman , Hanna Erdmann , Francisco Jimenez , Ralf Paus , Marta Bertolini Br J Dermatol, 2021 In this article, the therapeutic potential of the PPARγ agonist N-Acetyl-GED-0507-34-Levo (NAGED) in preventing chemotherapy-induced alopecia (CIA) is […]
We are proud to inform that we have recently been awarded with the crédit d’impôt recherche (CIR). This document has been handed by the French Ministry of superior teaching, research & innovation and awards our French customers a wide series of benefits regarding our investigations.
Monasterium Laboratory is searching for patients over 18 years old who suffer from Psoriasis Vulgaris to participate in their research by donating skin samples. The Collection Date will be 28/10/2021 Patients will be awarded with an allowance between 100€ and 320€. The main requirement is that the patient must not […]
It is with great pride that the whole team of Monasterium Laboratory congratulates its Principal Scientist, Dr. Marta Bertolini, on her appointment to an Expertscape World Expert in Hair. As part of National Alopecia Areata Awareness Month (September 2021), this is an outstanding honoring of ten years of profound scientific […]
Quantitative mapping of human hair greying and reversal in relation to life stressAyelet M Rosenberg, Shannon Rausser, Junting Ren, Eugene V Mosharov, Gabriel Sturm, R Todd Ogden, Purvi Patel, Rajesh Kumar Soni, Clay Lacefield, Desmond J Tobin, Ralf Paus, Martin PicardElife, 2021Hair fibres hold a ‘picture’ of a person’s recent life events in the patterns of hair pigmentation and proteins […]
γδT-cells are unconventional T lymphocytes that are only sparsely found in blood and secondary lymphoid organs. Instead, they are enriched in barrier organs such as the skin and can respond to conserved self and non-self antigens to assist in tissue immunosurveillance. Today, it is well accepted that γδT-cells, which express […]
Enzyme involved in lysosomal disorders has surprising role in hair pigmentation. The enzyme UDP-GlcNAc-1-Phosphotransferase (GNPTAB) is shown by the authors of a recent study to be a clinically important enzyme in the control of human hair pigmentation. GNPTAB is an enzyme that is involved in the correct intracellular shuttling […]
Dr. Marta Bertolini, Principal Scientist and Deputy General Manager at Monasterium Laboratory GmbH reports about state-of-the-art pre-clinical human skin models for cosmeceutical application, including hair follicle and scalp skin ex vivo models as tools to explore the effects of hair care products in Skinobs Cosmetic Testing News, FOCUS#4 (page 23). […]
Evidence from a humanized mouse model of androgenetic alopecia that platelet-rich plasma (PRP) stimulates hair regrowth, hair shaft diameter and vellus-to-terminal hair reconversion in vivo. Laufer Britva R et al., Br J Dermatol, 2021 Autologous platelet-rich plasma (PRP) has been increasingly used for androgenetic alopecia (AGA) management in both men […]
