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PPARγ signaling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transition

In News, Press Releases by Anja Borrosch

A common side-effect of cancer chemotherapy is hair loss, termed chemotherapy-induced alopecia (CIA). CIA is perhaps the most visual of the side-effects of chemotherapy and is highly distressing for patients who experience it. In most patients, this effect is temporary …

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Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle

In News, Press Releases by R. Adrian

γδT-cells are unconventional T lymphocytes that are only sparsely found in blood and secondary lymphoid organs. Instead, they are enriched in barrier organs such as the skin and can respond to conserved self and non-self antigens to assist in tissue …

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UDP-GlcNAc-1-phosphotransferase is a clinically important regulator of human and mouse hair pigmentation

In News, Press Releases by R. Adrian

Enzyme involved in lysosomal disorders has surprising role in hair pigmentation. The enzyme UDP-GlcNAc-1-Phosphotransferase (GNPTAB) is shown by the authors of a recent study to be a clinically important enzyme in the control of human hair pigmentation. GNPTAB is an …

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Hair Follicle Chemosensation: TRPM5 Signaling Is Required for Anagen Maintenance.

In News, Press Releases by Anja Borrosch

Being able to sense and process environmental cues is among the most fundamental requirements of life and thus not only restricted to the specialized cells that we use to smell and taste. In fact, a team of scientists from Monasterium …

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Plucking for better insights into hair growth and pigmentation: A new assay for human hair research

In News, Press Releases by Anja Borrosch

A team of researchers from the University of Manchester, University of Miami, and Monasterium Laboratory in Münster, Germany, have recently reported a novel methodology that closes an important gap in current hair research technology. The study published in the journal …

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Gamma-delta-T-cells: The resurfacing of a molecular malady linking Alopecia Areata pathobiologies

In Press Releases by Anja Borrosch

Investigations revealed the significance of the overlooked population of T-cells—the Gamma-delta-T-cells (γδT-cells)—in Alopecia Areata pathogenesis1 Our skin contains a varied population of T-cells, the crucial elements of the immune system that perform surveillance on specific foreign bodies. Even so, sometimes …

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Boosting innovation in anti-aging skin research: Monasterium Laboratory receives Germany’s prestigious innovation ZIM* grant, for developing a novel human skin aging ex vivo model

In Press Releases by Anja Borrosch

Anti-aging skincare research is a major topic in the cosmetics and nutraceuticals industry. There is a huge market demand and competition globally to develop novel products and strategies that tackle causes and signs of skin aging. Scientists in industry and …

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New players in skin inflammation/wounding?? de novo generation of tissue-resident macrophages from resident progenitor cells in adult human skin under neurogenic inflammatory attack!

In Press Releases by Anja Borrosch

Monocyte (MO)-derived macrophages (MACs) and self-renewable tissue-resident macrophages (tr-MACs) play an important role in regulating and maintaining MAC pool during inflammation in murine skin (1). However, our current understanding of MACs origin and their differentiation in peripheral tissues is limited …

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Promotion of human hair growth by adenosine goes beyond the effect on dermal papilla fibroblasts: new role for outer root sheath keratinocytes

In Press Releases by Anja Borrosch

It is long known that adenosine promotes hair growth. One of the proposed mechanism involves the regulation of hair cycle-associated growth factors production and release by dermal papilla fibroblasts. However, full characterization of the cellular mechanism by which adenosine regulates …

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Theophylline administration to ex vivo human skin shows multiple anti-aging and anti-cytotoxicity effects: Could theophylline be a potential anti-aging cosmeceutical?

In Press Releases by Anja Borrosch

Previous studies examining the topical application of theophylline in murine skin showed photodamage-protective properties (1). However, the effects of theophylline on human skin remains elusive. By using cutting-edge microscopy techniques and ex vivo assays, the research team at Monasterium Laboratory …