The USA, UK and Europe have recently approved the JAK inhibitor baricitinib/Olumiant® to treat severe cases of adult alopecia areata (AA). However, despite these good news, JAK inhibitors are still in an early stage of clinical investigation and until now …
Press Release – New Publication: An advocacy to use humanized mouse models for psoriasis research and pre-clinical drug development
Psoriasis is a chronic inflammatory skin disease characterized by dry, itchy and scaly patches. Patients suffer greatly from both, the negative features of the symptoms as well as psychologically from i.e. poor self-esteem or social isolation. For the development of …
Press Release: Intermediate Hair Follicles from Female Pattern Hair Loss Patients are characterized by nutrient insufficiency and a low metabolic activity
People throughout all cultures care greatly about keeping their hair healthy and strong, and the array of hair care products is continuously expanding. Whilst wash and care hair products might be enough for maintaining hair fiber health, more specialist treatments …
Press Release: Human skin – an easily accessible model to investigate organ rejuvenation?
“Age is an issue of mind over matter. If you don’t mind, it doesn’t matter.” Mark Twain Not everyone shares Mark Twain´s carefree view on aging. Quite the contrary, many individuals fear getting older. Therefore, effective strategies to prevent, …
Press Release: An extract from the alpine plant “Edelweiss” stimulates hair growth
In close collaboration with DSM , we showed that an extract of the alpine plant Leontopodium alpinum, or Edelweiss, inhibits hair loss in humans by prolonging the hair follicle growth phase, called anagen, during which the hair shaft, the visible …
Press Release: Monasterium Laboratory has been awarded the ISO9001:2015 Certification!
Monasterium Laboratory GmbH is delighted to have been awarded the ISO 9001:2015 certification from the TÜV Rheinland: “Execution of state-of-the-art preclinical and clinical services for cosmetology, dermatology, nutraceutical, and allergy applications” ISO 9001:2015 is an internationally recognized standard that …
White adipose tissue of the skin produces hormones that suppress hair growth and pigmentation in human hair follicles
Adiponectin is a hormone that is primarily secreted by white adipose tissue. High levels of adiponectin in the blood circulation are observed in diseases including fibrosis and diabetes. However, it positively influences skin function and it has anti-aging effects …
Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase
Hair follicles (HFs) in the growth stage (anagen) exhibit a great degree of cell division. On top of this, there is a high rate of protein synthesis to support keratinization of the growing hair fiber. As a result, the HF …
PPARÎł signaling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transition
A common side-effect of cancer chemotherapy is hair loss, termed chemotherapy-induced alopecia (CIA). CIA is perhaps the most visual of the side-effects of chemotherapy and is highly distressing for patients who experience it. In most patients, this effect is temporary …
Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle
γδT-cells are unconventional T lymphocytes that are only sparsely found in blood and secondary lymphoid organs. Instead, they are enriched in barrier organs such as the skin and can respond to conserved self and non-self antigens to assist in tissue …
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