The USA, UK and Europe have recently approved the JAK inhibitor baricitinib/Olumiant® to treat severe cases of adult alopecia areata (AA). However, despite these good news, JAK inhibitors are still in an early stage of clinical investigation and until now …
Issue 12: Current research highlights
Generation of a novel humanized mouse model for pre-clinical in vivo studies on androgenetic alopecia Amos Gilhar, Aviad Keren, Yehuda Ullmann, Jeff Wu, Ralf Paus Gilhar A, et al. Exp Dermatol, 2022 Male-pattern baldness, also known as androgenetic alopecia (AGA) is …
Issue 11: Current research highlights
Adiponectin negatively regulates pigmentation, Wnt/β‑catenin and HGF/c‑Met signalling within human scalp hair follicles ex vivo Carina Nicu, Jennifer Jackson, Asim Shahmalak, Jenny pople, David Ansell, Ralf Paus Arch dermatol Res, 2021 A compelling study comprising “the effect of the hormone …
Issue 10: Current research highlights
Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase Karazyna Figlak, Greg Williams, Ralf Paus , Marta Bertolini, Michael P. Philpott Br J Dermatol, 2021 Hair follicles (HFs) in the growth stage (anagen) exhibit a great …
Issue 9: Current research highlights
PPARγ signaling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transition Ilaria Piccini, Lars Brunken, Jérémy Chéret , Sushmita Ghatak, Yamus Ramot, Majid Alam , Talveen S Purba , Jonathan Hardman , Hanna Erdmann , Francisco Jimenez , Ralf Paus , Marta Bertolini Br J Dermatol, 2021 In this article, the therapeutic potential of the PPARγ …
Issue 8: Current research highlights
Quantitative mapping of human hair greying and reversal in relation to life stress Ayelet M Rosenberg, Shannon Rausser, Junting Ren, Eugene V Mosharov, Gabriel Sturm, R Todd Ogden, Purvi Patel, Rajesh Kumar Soni, Clay Lacefield, Desmond J Tobin, Ralf Paus, Martin Picard Elife, 2021 Hair fibres hold a ‘picture’ of a …
Issue 7: Current research highlights
Evidence from a humanized mouse model of androgenetic alopecia that platelet-rich plasma (PRP) stimulates hair regrowth, hair shaft diameter and vellus-to-terminal hair reconversion in vivo. Laufer Britva R et al., Br J Dermatol, 2021 Autologous platelet-rich plasma (PRP) has been …
Issue 6: Current research highlights
Compartmentalised metabolic programmes in human anagen hair follicles: New targets to modulate epithelial stem cell behaviour, keratinocyte proliferation and hair follicle immune status? Purba et al. Exp Dermatol 2021 Lactate, the end-product of aerobic glycolysis (Warburg effect), is important for …
Issue 5: Current research highlights
Re-innervation of human skin by rat dorsal root ganglia permits to study interactions between sensory nerve fibres and native human dermal mast cells ex vivo. Chéret J. et al., Exp. Dermatol., 2021 Despite several practical benefits, human skin organ cultures …
Issue 4: Current research highlights
Topical odorant application of the specific olfactory receptor OR2AT4 agonist, Sandalore®, improves telogen effluvium associated parameters. Jimenez. F et al., J Cosmet Dermatol, 2020 Excess hair shedding called telogen effluvium is one of the most common complaints in women yet …
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