Thanks to our great network of collaborating dermatologists and surgeons, we have ample access to tissue specimens of skin from healthy subjects and patients affected by skin disorders. Employing our extensive portfolio of techniques, we use these human skin specimen for the identification and characterization of new therapeutic targets. In addition, we use human primary cells, ex vivo organ culture of human full thickness skin, and humanized mouse in vivo models to validate new targets for skin disorders, as well as investigating mechanisms of action, and effects of compounds/formulations/drugs (also via topical application) for skin disorders management.
Our expertise also includes:
A wide range of parameters are available, and customized experiments can be designed to meet the needs of our customers.
We also have available human lesional skin organ cultures to test the efficacy of compounds ex vivo (an alternative use to animal experiments).
Keren et al., 2023, Wikramanayake et al., 2022, Gilhar et al., 2022, Gilhar et al., 2020, Keren et al., 2018, Olah et al., 2014, Hinde et al., 2013