Aging
We use primary epidermal keratinocytes and dermal fibroblasts, ex vivo organ culture of human hair follicles, and human full thickness skin and humanized mouse in vivo models to investigate whether compounds/formulations (also via topical application) inhibit hair or skin aging and protect from experimentally-induced aging/senescence (e.g. UV irradiation, H2O2). Specifically, as standardized readout parameters, we evaluate the following by immunohistology/quantitative (immuno-)histomorphometry, and in situ zymography (for details on our techniques, please click here):
In addition, using RNAseq, qRT-PCR, and/or in situ hybridization, we can analyze the expression of molecules involved in hair and skin aging, and assess these within specific compartments from skin or hair tissue sections following laser capture microdissection.
Additional readout parameters are available, and customized experiments can be designed to meet the needs of our customers.
Selected publications
Comprehensive & interdisciplinary expertise that covers the entire field of hair & skin research.
