Humanized mouse models
In close collaboration with Prof. Amos Gilhar, Technion Israel Institute, Haifa, Israel, we have access to unique humanized mouse models that employ human skin xenotransplantation onto severe combined immune-deficient (SCID) mice. By employing these models, we can investigate the effect of test agents on human hair growth, hair pigmentation, and on other numerous in vivo dermatological read-outs. These models are best suitable for therapeutic pre-clinical testing prior to the clinical trials.
If you are interested in access to these highly clinically relevant models, we will assist you with preparing the experimental design, instructing the team in Haifa to complete the study, performing the analysis, and preparing the report.
Currently available in vivo humanized mouse model which mimic skin and hair disorders:
- alopecia areata
- androgenetic alopecia
- chemo-induced alopecia
- atopic dermatitis
- skin aging
Gilhar et al. 2020, Keren et al. 2022, Laufer Britva et al. 2021, Alam et al., 2020, Gilhar et al., 2020, Gilhar et al, 2020, Laufer et al., 2020, Alam et al., 2019, Ghraieb et al., 2018, Keren et al., 2018, Gilhar et al., 2016, Oh et al.,2016, Keren et al., 2016, Gilhar et al., 2011, Shafer et al., 2010, Gilhar et al., 2004