Monasterium Laboratory’s Innovative Technologies Program

Together with our scientists and our established global network, we undertake translational research programs to develop and offer novel innovative tools, technologies and methodologies to our clients.

Besides co-funding several projects with world-renowned pharma or cosmetic companies to develop innovative technologies and methodologies (co-development projects, and co-founded PhD projects), our current in house Innovative Technologies Program aims at developing cutting-edge, clinically relevant human in vitro, ex vivo and in vivo models to be employed in skin and hair research to further expand the robust, versatile, one-of-a-kind service portfolio of the company.

We continuously launch many new innovative services for our clients; learn more about our latest services here.

 

Innovative Research: Sensory Reinnervation of Human Skin by Human Neural Stem Cell-Derived Peripheral neurons Ex Vivo

As example, please see Sensory Reinnervation of Human Skin by Human Neural Stem Cell‒Derived Peripheral Neurons Ex Vivo by Chéret et al, J Invest Dermatol. 2021. 

In this groundbreaking, methodological proof-of-principle study we provided the first compelling evidence that full-thickness human skin specimens (cultured under ex vivo conditions) can be rapidly and efficiently re-innervated with human iPSC-derived neural stem cells, using a well-defined, serum-free, nerve growth factor-supplemented culture medium, to re-establish an almost physiological sensory re-innervation pattern. This not only avoids the inherent complications arising from inter-species re-innervation assays (seen e.g. when applying sensory neurons derived from rodents) but also increases both the clinical relevance of data generated as well as the wide applicability of the model for assessing skin effects of pharmaceuticals, nutraceuticals, and, of great importance, cosmeceuticals (where animal tissues cannot be employed).

Our novel data states that sensory re-innervation improves epidermal proliferation, blood vessel and mast cell survival in organ-cultured human skin. This, further attests to the assay’s clinical relevance, as the trophic role of sensory innervation in human skin is well-appreciated. Thus, the novel Sensory Reinnervated Ex Vivo Human Skin Model developed by Monasterium Laboratory GmbH provides previously unavailable preclinical research opportunities for interrogating and therapeutically manipulating the bi-directional communication between primary human sensory nerve fibers and defined skin cell populations in native human skin, including nerve fiber interactions with keratinocytes, mast cells and endothelial cells, under physiological and pathological conditions.

Learn more about our latest publications here.

Please do not hesitate to contact us for any further discussion about our study design and innovation program.

Image