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YearTitleAuthorJournal LinkKeywords
2020Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under "pathological" conditions ex vivoPost H, Hundt JE, Zhang G, Depping R, Rose C, Langan EA, Paus R.Arch Dermatol Resread the full storyhypoxia, skin organ culture, Wound healing, preclinical
2020Does mitochondrial dysfunction of hair follicle epithelial stem cells play a role in the pathobiology of lichen planopilaris?Hardman-Smart JA, Purba TS, Panicker S, Farjo B, Farjo N, Harries MJ, Paus R.Br J Dermatolread the full storyT- cell mediated interferon-γ, immune privilege,
2020Vascular endothelial growth factor blockade induces dermal endothelial cell apoptosis in a clinically relevant skin organ culture modelLuengas-Martinez A, Hardman-Smart J, Rutkowski D, Purba TS, Paus R, Young HSSkin Pharmacol Physiolread the full story anti-VEGF, endothelial cell apoptosis, human skin ex vivo, microvascular network, Psoriasis
2020Non‐neuronal kappa‐opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex vivoChéret J, Gherardini J, Soeberdt M, Hundt JE, Abels C, Bertolini M, Paus RJ Dermatolread the full storyneurogenic inflammation, human skin organ culture, keratinocyte apoptosis, inflammatory dermatoses
2020Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermisOláh A, Alam M, Chéret J, Kis NG, Hegyi Z, Szöllősi AG, Vidali S, Bíró T, Paus RExp Dermatolread the full story keratinocyte mitochondrial activity, cannabinoid receptor 1, organ-cultured full-thickness human skin, ROS production, skin aging, photodamage
2020Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 SkewingDel Duca E, Ruano Ruiz J, Pavel AB, Sanyal RD, Song T, Gay-Mimbrera J, Zhang N, Estrada YD, Peng X, Renert-Yuval Y, Phelps RG, Paus R, Krueger JG, Guttman-Yassky E.Br J Dermatolread the full storylesional, nonlesional scalp biopsies, stem cells, follicular damage, JAK/STAT-targeting treatments
2020Hair(y) matters in melanoma biologyBarbara Bedogni, Ralf PausTrends in Molecular Medicineread the full storymetastatic melanoma, melanocytes, immune-privileged microenvironment, stem cells, melanoma prevention strategy
2020New effects of caffeine on CRH-induced stress along the intrafollicular classical HPA-axis (CRH-R1/2, IP3 -R, ACTH, MC-R2) and the neurogenic non-HPA-axis (substance P, p75NTR and TrkA) in ex vivo human male androgenetic scalp hair follicles.Fischer TW, Bergmann A, Kruse N, Kleszczynski K, Skobowiat C, Slominski AT, Paus RBr J Dermatolread the full storyhuman hair, androgenetic alopecia, stress-induced hair loss, hair organ culture model, caffeine
2020An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytesAlam M, Bertolini M, Gherardini J, Keren A, Ponce L, Chéret J, Alenfall J, Dunér P, Nilsson AH, Gilhar A, Paus RBr J Dermatolread the full storyhuman scalp skin xenotransplant, human hair follicle organ culture, hypertrichosis, hirsutism, hair growth
2020Adenosine promotes human hair growth and inhibits catagen transition in vitro - role of the outer sheath keratinocytes. Lisztes E, Toth BI, Bertolini M, Szabo IL, Zakany N, Olah A, Szollosi AG, Paus R, Biro T. J Invest Dermatolread the full storyhair follicle, ex vivo, organ culture, co-immunolabeling, G-protein, hair growth
2020Toward predicting the spatio-temporal dynamics of alopecia areata lesions using partial differential equation analysis.Atanaska Dobreva, Ralf Paus, N. G. Cogan Bull Math Biolread the full storyautoimmune disease, alopecia areata, partial differential equations, humanized mouse model
2020Fluoxetine promotes human hair follicle pigmentation ex vivo: Serotonin re-uptake inhibition as a new anti-greying strategy?Cheret J, Gherardini J, Bertolini M, Paus R. Br J Dermatolread the full storyhair follicle, ex vivo, organ culture, quantitative Masson-Fontana histomorphometry, serotonin receptor, melanotropic neurohormone
2020Do hair follicles operate as primitive, multifocal kidney-like excretory (mini-)organs?Carré JL, Suzuki T, Paus RExp Dermatolread the full storytrichocytes, hair shafts, classical nephrological therapy, erythropoietin synthesis
2020Neuroendocrinology and neurobiology of sebaceous gland.Clayton RW, Langan EA, Ansell DM, de Vos IJHM, Göbel K, Schneider MR, Picardo M, Lim X, van Steensel MAM, Paus RBiol Rev Camb Philos Socread the full storynervous system, pituitary control, sebaceous glands, homeostasis
2020Phytocannabinoid(-)-Cannabidiol operates as a complex, differential modular of human hair growth: Anti-inflammatory sub-micromolar versus hair growth inhibitory micromolar effects.Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro TJ Invest Dermatolread the full storyhair follicle, ex vivo organ culture, toll-like receptor, hair morphology
2020Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata.Laufer BR, Keren A, Paus R, Gilhar A.Br J Dermatolread the full storyhair loss, hair follicle, phosphodiesterase inhibitor, therapeutics
2020Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during subtance P-mediated neurogenic inflammation ex vivo.Gherardini J, Uchida Y, Hardman JA, Cheret J, Mace K, Bertolini M, Paus RPLoS Oneread the full storymacrophages, full-thickness skin organ culture, immunohistochemistry, neuroinflammatory stimulus
2020Schwann cells as underestimated, major players in human skin physiology and pathology. Bray ER, Cheret J, Yosipovitch G, Paus R. Exp Dermatolread the full storyaxon regeneration, wound healing, atopic dermatitis, psoriasis
2020Theophylline exerts complex anti-aging and anti-cytotoxicity effects in human skin ex vivo.Bertolini M, Ramot Y, Gherardini J, Heinen G, Cheret J, Welss T, Giesen M, Funk W, Paus R. Int J Cosmet Sciread the full storyfull thickness skin, organ culture, ex vivo, phosphodiesterase inhibitor, metallothionein‐1, collagen, skin‐protective properties
2019JAK inhibitors and alopecia areata.Gilhar A, Keren A, Paus R.Lancetread the full storysystemic therapy, cytokines, autoimmune disease
2019Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine.Gherardini J, Wegner J, Cheret J, Ghatak S, Lehmann J, Alam M, Jimenez F, Funk W, Bohm M, Botchkareva NV, Ward C, Paus R, Bertolini M.Int J Cosmet Sciread the full storyex vivo, organ culture, UV exposure, keratinocyte apoptosis, photoprotectants, clinical relevance
2019Nestin(+) progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo.Liao T, Lehmann J, Sternstein S, Yay A, Zhang G, Matthiessen AE, Schumann S, Siemers F, Kruse C, Hundt JE, Langan EA, Tiede S, Paus R.Arch Dermatol Resread the full storyskin punch biopsies, ex vivo, wound healing model, pre-clinical, regenerative medicine, chronic skin ulceration
2019Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle?Nicu C, Hardman JA, Pople J, Paus R.Exp Dermatolread the full storyhair follicle, transmission electron microscopy, anagen‐catagen transition, lipogenesis, hair cycle
2019Assessment of Quality of Life and Treatment Outcomes of Patients with persistent postchemotherapy alopecia.Freites-Martinez A, Chan D, Sibaud V, Shapiro J, Fabbrocini G, Tosti A, Cho J, Goldfarb S, Modi S, Gajria D, Norton L, Paus R, Cigler T, Lacouture ME.JAMA Dermatolread the full storypersistent chemotherapy-induced alopecia, clinical study, hair loss, patinets, dermatologic therapy
2019Hair growth control by innate immunocytes: Perifollicular macrophages revisited.Muneeb F, Hardman JA, Paus R.Exp Dermatolread the full storyhair matrix, hair cycle stage, hair follicle morphogenesis, Wnt signalling, clinically relevant
2019Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo.Zhang GY, Langan EA, Meier NT, Funk W, Siemers F, Paus R.PLoS Oneread the full storyfull thickness human skin, wound healing organ culture model, quantitative immunohistomorphometry, pre-clinical testing, keratin expression, energy metabolism
2019Distinct patterns of hair graft Survival After Transplantation into 2 Nonhealing Ulcers: Is Location Everything?Alam M, Cooley J, Plotczyk M, Martinez-Martin MS, Izeta A, Paus R, Jimenez F.Dermatol Surgread the full storyhair follicles, scar formation, hair growth, wound healing, human skin
2019Image Gallery: Optical coherence tomography for intravital human hair follicle analyses ex vivo.Lehmann J, Kemper B, Barroso Pena A, Schnekenburger J, Paus R, Bertolini M, Cheret J.Br J Dermatolread the full storylabel‐free, high‐resolution, anatomical details, ex vivo, organ culture, hair matrix
2019Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis.Leon A, Rosen JD, Hashimoto T, Fostini AC, Paus R, Yosipovitch G.Exp Dermatolread the full storyhair follicle, mast cells, neurogenic inflammation, psoriatic scalp itch, immunogenic inflammation
2019Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis.Clayton RW, Gobel K, Niessen CM, Paus R, van Steensel MAM, Lim X.Br J Dermatolread the full storygenetic mouse models, mammalian skin, acne vulgaris, comedones, acne pathogenesis
2019Hair disorders in patients with cancer.Freites-Martinez A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME.J Am Acad Dermatolread the full storychemotherapy induced alopecia, hair repigmentation, immunotherapies, oncology patients
2019Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias.Harries M, Imanishi H, Paus R.J Am Acad Dermatolread the full storylaser capture microdissection, microarray analysis, hair follicle, immune privilege collapse, follicular inflammation
2019TRPV4 is expressed in human hair follicles and inhibits hair growth in vitro.Szabo IL, Herczeg-Lisztes E, Szegedi A, Nemes B, Paus R, Biro T, Szollosi AG.J Invest Dermatolread the full storycalcium permeable, microflorimetric Ca2+ measurement, outer root sheath keratinocytes, peripheral sensory nerves
2019Growth hormone operates as a neuroendocrine regulator of human hair growth ex vivo. Alam M, Below DA, Cheret J, Langan EA, Bertolini M, Jimenez F, Paus R.J Invest Dermatol read the full storyhuman hair follicle, ex vivo, organ culture, mini-organ, neuropeptides, pigmentation
2019Alopecia areata patients show deficiency of FOXP3+CD39+ T regulartory cells and clonotypic restriction of Treg TCRß-chain, which highlights the immunopathological aspect of disease.Hamed FN, Astrand A, Bertolini M, Rossi A, Maleki Dizaji A, Messanger AG, Mc Donagh AJG, Tazi-Ahnini R. PloS Oneread the full storyflow cytometry, next Generation Sequencing, hair loss, Treg clonotypes, autoimmune reaction
2019Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation. Hawkshaw NJ, Hardman JA, Alam M, Jimenez F, Paus R. Br J Dermatolread the full storyin situ hybridization, human telogen, scalp hair follicle sections, hair biology
2019Inhibition of ATP binding cassette transporter B1 sensitizes human hair follicles to chemotherapy-induced damage. Smart E, Farjo N, Farjo B, Haslam IS, Paus R.J Dermatol Sciread the full storyquantitative immunohistomorphometry, 4-hydroxycyclophosphamide, anthracycline doxorubicin, ex vivo, proliferation, apoptosis
2019The Phytocannabinoid (-)-Cannabidiol operates as a complex, differential modulator of human hair qrowth: anti-inflammatory submicromolar versus hair growth inhibitory micromolar effects.Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro T. J Invest Dermatolread the full storyhair follicle, organ culture, hair shaft, hair cycle, hair matrix keratinocytes
2019Seborrheic dermatitis-Looking beyond Malassezia. Wikramanayake TC, Borda LJ, Miteva M, Paus R. Exp Dermatolread the full storychronic, relapsing inflammatory, skin disease, Mpzl3 knockout mice, epidermal barrier, sebaceous activity
2019CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia. Purba TS, Ng'andu K, Brunken L, Smart E, Mitchell E, Hassan N, O'Brien A, Mellor C, Jackson J, Shahmalak A, Paus R. EMBO Mol Med read the full storyhair follicle, organ culture, epithelial bulge stem cell analysis, chemotherapy, paclitaxel, docetaxel, mitotic defects
2019PPAR-Y signalling as a key mediator of human hair follicle physiology and pathology. Ramot Y, Bertolini M, Bobolijava M, Uchida Y, Paus R. Exp. Dermatolread the full storyhair follicle development, scarring alopecia, epithelial-mesenchymal transition, androgenetic alopecia
2019Precilinal evidence that PPARγ- modulator, N-Acetyl-GED-0507-34-Levo, may protect human hair follicle epithelial stem cells against lichen planopilaris -associated damage.Cheret J, Piccini I, Hardman-Smart J, Ghatak S, Alam M, Lehmann J, Jimenez F, Erdmann H, Poblet E, Botchkareva N, Paus R, Bertolini M. J Eur Acad Dermatol Vernereolread the full storyhair follicle, ex vivo, organ culture, immunohistochemistry, NAGED, hair loss, lichen planopilaris
2019Mineralocorticoid receptor antagonists stimulate human hair growth ex vivo. Hundt JE, Sass S, Funk W, Biro T, Farman N, Langan EA, Paus R. Skin Pharmacol Physiolread the full storyhair follicle, ex vivo, organ culture, glucocorticoid, hair cycle
2019Y-27632 preserves epidermal intregity in a human skin-organ culture (h-SOC) system by regulating AKT and ERK signalling pathways. Zang X, Qin J, Xie Z, Liu C, Su Y, Chen Z, Zho Q, Ma C, Liu G, Paus R, Guo J, Wu X. J Dermatol Sciread the full storyhuman breast skin, organ culture, ex vivo, epidermal cell proliferation, immunofluorescence staining, ROCK inhibitor, epidermal architecture
2019Frontiers in alopecia areata pathobiology research.Gilhar A, Britva RL, Keren A, Paus R.J Allergy Clin Immunolread the full storyhumanized mouse model, autoantigens, regulatory T cells, immune privilege
2019Human perifollicular macrophages undergo apoptosis, express Wnt ligands and switch their polarization during catagen.Hardman JA, Muneeb F, Pople J, Bhogal R, Shahmalak A, Paus R. J Invest Dermatolread the full storyhuman hair follicle, ex vivo, organ culture, hair cycle, inflammatory hair disease
2019Model-based approach to the design of pharmaceutical roller-compaction processes.Toson P, Lopes DG, Paus R, Kumar A, Geens J, Stibale S, Quodbach J, Kleinebudde P, Hsiao WK, Khinast J. Int J Pharmread the full storymathematical model, in-silico, ibuprofen formulations, iterative calibration
2018Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-alpha administration differ during wound repair and regeneration. Abarca-Buis RF, Martinez-Jimenez A, Vera-Gomez E, Contreras-Figueroa ME, Garciadiego-Cazares D, Paus R, Robles-Tenorio A, Krotzsch E. Differentiation read the full storyear punch wound mouse model, histology analysis, fibrotic scarring, epidermal apoptosis
2018Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management.Paus R, Bulfone-Paus S, Bertolini M. J Investig Dermatol Symp Procread the full storyhair bulb, pharmacological manipulation, Immune privilege collapse-related autoimmune diseases
2018An efficient method for eccrine gland isolation from human scalp.Jimenez F, Alam M, Hernandez I, Poblet E, Hardman JA, Paus R. Exp Dermatolread the full storyhair graft harvesting method, calp follicular unit grafts, microdissection, methylene blue staining
2018NF-kappaB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types.Krieger K, Millar SE, Mikuda N, Krahn I, Kloepper JE, Bertolini M, Scheidereit C, Paus R, Schmidt-Ullrich R.J Invest Dermatolread the full storyhumanized mouse model, hair cycle analysis, histological techniques, anagen induction, telogen−anagen transition
2018Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue.Poblet E, Jimenez F, Escario-Travesedo E, Hardman JA, Hernandez-Hernandez I, Agudo-Mena JL, Cabrera-Galvan JJ, Nicu C, Paus R. Br J Dermatolread the full story3D reconstruction, human scalp, follicular unit transplant grafts, scalp strip ex vivo, human skin adnexa
2018Epithelial-to-mesenchymal stem cell transition in a human organ: Lessons from lichen planopilaris.Imanishi H, Ansell DM, Cheret J, Harries M, Bertolini M, Sepp N, Biro T, Poblet E, Jimenez F, Hardman J, Panicker SP, Ward CM, Paus R.J Invest Dermatolread the full storyhair follicle, ex vivo organ culture, immunohistochemistry, transmission electron microscopy, preclinical assay
2018Prolactin as a candidate sebotrop(h)ic hormone?Langan EA, Hinde E, Paus R. Exp Dermatolread the full storyhuman dermatoses, sebaceous gland, therapeutic strategies, cutaneous ageing
2018 A guide to studying human dermal adipocytes in situ.Nicu, C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. Exp Dermatolread the full storyquantitative immunohistomorphometry, dermal white adipose tissue, in situ hybridization, neuroendocrinology
2018Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture.Parodi C, Hardman JA, Allavena G, Marotta R, Catelani T, Bertolini M, Paus R, Grimaldi B.  PLoS Biolread the full storycell culture, quantitative immunohistomorphometry, ex vivo, knockdown, preclinical research model
2018Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg total deletion.Sardella C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F. J Invest Dermatolread the full storyhumanized mouse model, skin grafts, in vivo, gene expression, adipose tissue-mediated signals
2018Melatonin: A cutaneous perspective on its production, metabolism, and functions.Slominski AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ, Paus R. J Invest Dermatolread the full storyhair follicle, photo-protection, anti-cancer activity, wound healing, pigmentation, inflammatory dermatoses
2018Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal. Foster AR, Nicu C, Schneider MR, Hinde E, Paus R. Arch Dermatol Resread the full story in vivo BODIPY, immunohistomorphometry, wound healing, adipocyte hypertrophy
2018Lichen planopilaris and frontal fibrosing alopecia as model epithelial stem cell diseases.Harries MJ, Jimenez F, Izeta A, Hardman J, Panicker SP, Poblet E, Paus R. Trends Mol Medread the full storyhair follicle, PPAR-γ, epithelial-mesenchymal transition, immune-privilege
2018Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles.Hawkshaw NJ, Hardman JA, Haslam IS, Shahmalak A, Gilhar A, Lim X, Paus R.PLoS Biolread the full storyhair follicle, ex vivo organ culture, Quantitative immunohistomorphometry, bioinformatics, immunosuppressant, therapeutic strategy
2018How UV light touches the brain and endocrine system through skin, and why.Slominski AT, Zmijewski MA, Plonka PM, Szaflarski JP, Paus R. Endocrinologyread the full storyenvironmental factors, UV radiation, body homeostasis, neuro-endocrine system
2018Image Gallery: Intravital visualization of the dynamic changes in human hair follicle cycling.Alam M, Hernandez I, Paus R, Jimenez F.Br J Dermatolread the full storyanagen, catagen, telogen, methylene blue staining, hair cycle stage
2018Topically applied nicotinamide inhibits human hair follicle growth ex vivo.Haslam IS, Hardman JA, Paus R. J Invest Dermatolread the full storyorgan culture, microdissected human scalp hair follicles, hair growth inhibitor, catagen, mast cells
2018Re-investigating the basement membrane zone of psoriatic epidermal lesions: Is laminin-511 a new player in psoriasis pathogenesis?Natsumi A, Sugawara K, Yasumizu M, Mizukami Y, Sano S, Morita A, Paus R, Tsuruta D.J Histochem Cytochemread the full storyskin tumorectomy, immunohistochemistry, transmission electron microscopy, laminin-511, keratinocyte growth/death
2018Cover Image: Neuroendocrine treatment of inherited keratin disorders by cannabinoids?Ramot Y, Olah A, Paus R.Br J Dermatolread the full storyuman skin organ culture, ex vivo, epidermolytic ichthyosis, keratin disorders, cannabinoid signalling
2018iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata. Ghraieb A, Keren A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A.J Autoimmunread the full storyhumanized mouse model, xenotransplants, lymphocytes, therapeutic potential
2018Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin.Keren A, Shemer A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A. J Allergy Clin Immunolread the full storyhumanized mouse model, sublethal irradiation, immunohistochemical analysis, cytokine analyses, psoriatic lesions
2018Peroxisome Proliferator-Activated Receptor-gamma-Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium.Ramot Y, Alam M, Olah A, Biro T, Ponce L, Cheret J, Bertolini M, Paus R.J Invest Dermatolread the full story ex vivo organ culture, gene expression, N-Acetyl-GED, mitochondrial function, ORS keratinocytes
2018Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling.Dobreva, A, Paus R, Cogan NG.Math Med Biol read the full storymathematical modelling, anagen phase interruption, therapeutic targets
2018Visualization of global RNA synthesis in a human (mini-) organ in situ by click chemistry.Purba TS, Marsh J, Ng'andu K, Kurinna S, Paus R. Biotechniquesread the full storyhuman hair follicle, ex vivo organ culture, in situ RNA synthesis, 5-ethynyl uridine
2018Bridging the "Dead hair"-"live follicle" divide in applied hair research.Bertolini M, Botchkareva N, Westgate G, Ward C, Cornwell P, Paus R. J Cosmet Sciread the full story synopsis, mini-organ, hair shaft structure
2018Olfactory receptor OR2AT4 regulates human hair growth.Cheret J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M, Hatt H, Paus R. Nat Communread the full storyex vivo, organ culture, knockdown, histological analysis, genome-micro array analysis, sandalore, synthetic sandalwood, hair growth, hair loss therapy
2018A technique for more precise distinction between catagen and telogen human hair follicles ex vivo. Hernandez I, Alam M, Platt C, Hardman J, Smart E, Poblet E, Bertolini M, Paus R, Jimenez F. J Am Acad Dermatolread the full storyex vivo organ culture, hair cycle stage, macroscopic analysis 
2018Transcriptional programming of normal and inflamed human epidermis at single-cell resolution. Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ.Cell Repread the full storycomputational analysis, single-cell RNAseq, keratinocyte 
2018Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P-induced human mast cell activation and degranulation in the hair follicle. Jadkauskaite L, Bahri R, Farjo N, Farjo B, Jenkins G, Bhogal R, Haslam I, Bulfone-Paus S, Paus R. J Allergy Clin Immunolread the full story ex vivo organ culture, immunohistochemistry, mast cells degranulation and activity assay, neuropeptide, androgenetic alopecia, alopecia areata
2018Bi-allelic mutations in LSS, encoding lanosterol synthase, cause autosomal-recessive hypotrichosis simplex.Romano, MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmuller J, Nurnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lutjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC.Am J Hum Genetread the full storywhole-exsome sequencing, alopecia, cholesterol biosynthetic pathway, lanosterol synthase
2018The renaissance of human skin organ culture: A critical reappraisal. Zhou L, Zhang X, Paus R, Lu Z.Differentiationread the full storyex vivo, morphological analyses, gene silencing, assays
2018Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding?Langan EA, Fink T, Paus R. Arch Dermatol Resread the full storyex vivo, human skin organ culture, PRL receptor antagonists, keratinocyte differentiation
2018Retinoic acid co-treatment aggravates severity of dioxin-induced skin lesions in hairless mice via induction of inflammatory response.Rudyak SG, Usakin LA, Tverye EA, Orekhov AS, Belushkina NN, Paus R, Paltsev MA, Panteleyev AA.Biochem Biophys Res Communread the full storyhumanized mouse model, halogenated polyaromatic hydrocarbons, skin pathologies, keratinocyte
2017Oxidative damage control in a human (mini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition.Haslam IS, Jadkauskaite L, Szabo IL, Staege S, Hesebeck-Brinckmann J, Jenkins G, Bhogal RK, Lim FL, Farjo N, Farjo B, Biro T, Schafer M, Paus R. J Invest Dermatol read the full storyhuman hair follicle, organ culture, ex vivo, quantitative immunofluorescence, ROS, keratinocytes
2017Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nothen MM.Nat Communread the full storygeno-wide analysis, meta-analysis, hair follicle cycling, therapeutics
2017Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology.Jumper N, Hodgkinson T, Paus R, Bayat A. PLoS Oneread the full storysite-specific in situ microdissection, transcriptome array analysis, 2D cell culture, TGFβ-mediated signaling
2017Enhanced neurogenic biomarker expression and reinnervation in human acute skin wounds treated by electrical stimulation.Sebastian A, Volk SW, Halai P, Colthurst J, Paus R, Bayat A. J Invest Dermatolread the full storyHuman punch biopsy, wound healing, microarray analysis, in vivo repair, neuroblastoma
2017Cover Image: Are melanocyte-associated peptides the elusive autoantigens in alopecia areata?Bertolini M, Rossi A, Paus R.Br J Dermatolread the full storyhair follicle, hair matrix melanocytes, mast cells, autoantigens, melanogenesis
2017Regulatory T cells in skin facilitate epithelial stem cell differentiation. Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. Cellread the full storyimmune-profiling, immunofluorescent microscopy, in vivo mouse model, skin inflammation, telogen-anagen transition, Jagged 1, hair regeneration, alopecia areata
2017Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1beta-mediated signaling. Stojadinovic O, Wikramanayake TC, Villasante Fricke AC, Yin NC, Liang L, Hinde E, Escandon J, Tomic-Canic M, Ansell DM, Paus R, Jimenez JJ. Heliyonread the full storyKeywords: incisional wound induction, histological analysis, cytokine injection, Gene expression profiling, hair cycle, IL-1β signaling
2017Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmuller J, Stander S, Luger T, Paus R, Cheret J, Hatt H.Exp Dermatolread the full storyhuman keratinocytes culture, cAMP‐dependent pathway, skin diseases, wound repair
2017Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?Jadkauskaite L, Coulombe PA, Schafer M, Dinkova-Kostova AT, Paus R, Haslam IS.Bioessaysread the full storyredox homeostasis, NRF2 activation, hair follicle pathologies
2017E-cadherin-mediated cell contact controls the epidermal damage response in radiation dermatitis.Xie G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H, Ramot Y, Paus R, Yue Z.J Invest Dermatolread the full storyhuman skin biopsy, footpad mouse model, in vivo rescue, epidermal keratinocytes, radiotherapy
2017Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix.Purba TS, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, Ceballos L, Gandarillas A, Paus REur J Cell Biol read the full storyhuman hair follicle, ex vivo organ culture, in situ hybridisation, CIP/KIP proteins, hair bulb growth
2017T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle.Oelert T, Gilhar A, Paus R. Exp Dermatolread the full storyhair follicle, immune privilege collapse, CD4+ regulatory T cells, alopecia areata
2017A role for neuregulin-1 in promoting keloid fibroblast migration via ErbB2-mediated signaling.Jumper N, Hodgkinson T, Paus R, Bayat A. Acta Derm Venereol read the full storylaser capture microdissection, in situ gene expression profiling, NRG1/ErbB2/Src/PTK2 signaling pathway, fibroproliferative tumour
2017Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2.Purba TS, Peake M, Farjo B, Farjo N, Bhogal RK, Jenkins G, Paus R. Sci Repread the full storyex vivo, hair follicle organ culture, Immunofluorescence, Quantitative immunohistomorphometry, epithelial stem cells
2016Hair follicle bulge stem cells appear dispensable for the acute phase of wound re-epithelialization. Garcin CL, Ansell DM, Headon DJ, Paus R, Hardman MJ. Stem Cellsread the full story wound healing, transgenic mice, in vivo
2016An innovative approach to dissecting keloid disease leading to identification of the retinoic acid pathway as a potential therapeutic target.Jumper N, Paus R, Bayat A. Plast Reconstr Surg Glob Openread the full storyskin biopsies, laser capture microdissection, epidermis
2016A Guide to studying human hair follicle cycling in vivo.Oh JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS, Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV.J Invest Dermatolread the full storypre-clinical, xenograft, immuno-histochemistry
2016Lhx2 is a direct NF-kappaB target gene that promotes primary hair follicle placode down-growth. Tomann P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R. Development read the full storygene expression, transcriptome, embryos, cell migration
2016Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice.Dahlhoff M, Camera E, Schafer M, Emrich D, Riethmacher D, Foster A, Paus R, Schneider MR.Developmentread the full storygene targeting, mouse line, in vivo, meibomian gland disease
2016p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a rat model of radiation dermatitis. Liao C, Xie G, Zhu L, Chen X, Li X, Lu H, Xu B, Ramot Y, Paus R, Yue Z. J Invest Dermatol read the full storychip analysis, in vivo, therapeutic targeting, dermatoses
2016Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse.Bertolini M, Pretzlaff M, Sulk M, Bahr M, Gherardini J, Uchida Y, Reibelt M, Kinori M, Rossi A, Biro T, Paus R.Br J Dermatolread the full storyhair follicle organ culture, immuno‐histomorphometry, autoimmune disorder
2016A primer for studying cell cycle dynamics of the human hair follicle. Purba TS, Brunken L, Hawkshaw NJ, Peake M, Hardman J, Paus R. Exp Dermatol read the full storyimmuno-labelling, cell cycle, proliferation, apoptosis
2016Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue.Bagabir RA, Syed F, Shenjere P, Paus R, Bayat A.J Invest Dermatol read the full storymolecular diagnostic, biomarker, immunohistochemistry, dermal scarring
2016Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.Gilhar A, Schrum AG, Etzioni A, Waldmann H, Paus R.Autoimmun Revread the full storyxenografts, transplantation, SCID mice, therapeutic strategies
2016The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease.Jumper N, Hodgkinson T, Arscott G, Har-Shai Y, Paus R, Bayat A.J Invest Dermatol read the full storylaser capture microdissection, microarray, luciferase assay, metabolism
2016The gut-skin axis in health and disease: A paradigm with therapeutic implications.O'Neill CA, Monteleone G, McLaughlin JT, Paus R. Bioessaysread the full storymicrobiota, signaling pathways, skin co‐morbidities
2016The thyroid hormone analogue KB2115 (Eprotirome) prolongs human hair growth (anagen) ex vivo.Olah A, Gherardini J, Bertolini M, Cheret J, Ponce L, Kloepper J, Biro T, Soeberdt M, Abels C, Paus R. J Invest Dermatolread the full storyhuman scalp hair follicle, organ culture, hair cycle, translational human hair research
2016Exploring the "brain-skin connection": Leads and lessons from the hair follicle.Paus R. Curr Res Transl Medread the full storyhuman hair follicle, organ culture, neuro-hormone, skin epithelium, Melatonin
2016Biology of the eyelash hair follicle: an enigma in plain sight. Paus R, Burgoa I, Platt CI, Griffiths T, Poblet E, Izeta A. Br J Dermatol read the full storymini-organ culture, greying, cosmetic manipulation
2016Mutations in TSPEAR, encoding a regulator of notch signaling, affect tooth and hair follicle morphogenesis.Peled A, Sarig O, Samuelov L, Bertolini M, Ziv L, Weissglas-Volkov D, Eskin-Schwartz M, Adase CA, Malchin N, Bochner R, Fainberg G, Goldberg I, Sugawara K, Baniel A, Tsuruta D, Luxenburg C, Adir N, Duverger O, Morasso M, Shalev S, Gallo RL, Shomron N, Paus R, Sprecher E.PLoS Genetread the full storysiRNA, NOTCH1 reporter assay, knockdown in mice hair follicles, organ cultures, apoptosis, ectodermal dysplasias
2016 Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit? Poblet E, Jimenez-Acosta F, Hardman JA, Escario E, Paus R. Exp Dermatol read the full story3D imaging, scalp follicular units, skin appendages
2016Thyroid hormones enhance mitochondrial function in human epidermis.Vidali S, Cheret J, Giesen M, Haeger S, Alam M, Watson REB, Langton AK, Klinger M, Knuever J, Funk W, Kofler B, Paus R.J Invest Dermatolread the full story Human skin organ culture, ex vivo, immunohistochemistry, Transmission electron microscopy, In situ zymography, skin aging, mitochondrial function
2016Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis.Fleger-Weckmann A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. Matrix Biol read the full story Hair follicle formation, histological analysis, electron microscopy, mouse model, hair shaft differentiation, basement membrane