Up to now, research on the “dead hair” and “live follicle” has been completed separated. However, responses occurring in the “live follicle” are likely to contribute to important changes in the “dead hair” structure, and quality. By partnering up with …

Understanding of mechanisms of cellular aging in humans requires reliable models that can rapidly reproduce key aspects of aging both in vitro and ex vivo. These pre-clinical models are also essential for the successful development of potent anti-ageing therapeutic and …

We collaborate with Lipotype GmbH, Dresden Germany and have established a novel technique to perform high-resolution shotgun lipidomics analysis on micro-dissected human hair follicles. Together with our partner, we can investigate effectively whether any compound or formulations affect the lipid …

Bulk gene profiles of hair follicles is often not optimal for investigating the response of certain small hair follicle cell populations, e.g. dermal papilla. Therefore, we routinely apply laser capture microdissection (LCM) to isolate small cell populations from human hair …

In collaboration with the team from Biomedical Technology Center, University of Münster, we have established an advanced intra-vital method to obtain high-resolution anatomical details of micro-dissected human hair follicles based on the label free-optical coherence tomography technique. Applications This method …

Wound healing is a highly complex dynamic process that involves the activation of several signalling pathways. In case of pathological environment such as age, diabetes and cancer, wound healing becomes more critical and can be chronically disrupted. We have established …

To understand the impact of UV (ultraviolet) irradiation on human hair follicle homeostasis is very important. We have established a new ex vivo assay to investigate how solar UVR that hits the human scalp skin surface effects hair follicle physiology. …

To reliably distinguish different phases of the hair cycle e.g. late catagen and telogen by stero-microscopy alone is challenging and requires histological analysis. In order to tackle this problem, we have established an intravital technique, based on meythelene blue staining, …

Together with Serend-ip GmbH, Münster, Germany, we have launched a novel service for investigating the nanotexture of corneocytes by atomic force microscopy of  healthy human or atopic dermatitis skin organ culture ex vivo, or in the humanized model for atopic …

We collaborate with Prof. Dr. Amos Gilhar, Technion Israel Institute, Israel to establish a novel humanized mouse model for atopic dermatitis (AD). Our AD model recapitulates all the key features of the disease that are required for the preclinical development …