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Preclinical assay for predicting the impact of nutraceuticals and cosmeceutical on human hair shaft quality

In New services by Anja Borrosch

Up to now, research on the “dead hair” and “live follicle” has been completed separated. However, responses occurring in the “live follicle” are likely to contribute to important changes in the “dead hair” structure, and quality. By partnering up with …

In vitro model for chronological (intrinsic) aging

In New services by Anja Borrosch

Understanding of mechanisms of cellular aging in humans requires reliable models that can rapidly reproduce key aspects of aging both in vitro and ex vivo. These pre-clinical models are also essential for the successful development of potent anti-ageing therapeutic and …

Lipidomics analysis of human hair follicle and hair shaft

In New services by Anja Borrosch

We collaborate with Lipotype GmbH, Dresden Germany and have established a novel technique to perform high-resolution shotgun lipidomics analysis on micro-dissected human hair follicles. Together with our partner, we can investigate effectively whether any compound or formulations affect the lipid …

High-quality RNA sequencing analysis on human hair follicle compartments after laser capture micro-dissection

In New services by Anja Borrosch

Bulk gene profiles of hair follicles is often not optimal for investigating the response of certain small hair follicle cell populations, e.g. dermal papilla. Therefore, we routinely apply laser capture microdissection (LCM) to isolate small cell populations from human hair …

Advanced label free-optical coherence tomography

In New services by Anja Borrosch

In collaboration with the team from Biomedical Technology Center, University of Münster, we have developed an advanced intra-vital method to obtain high-resolution anatomical details of micro-dissected human hair follicles based on the label free-optical coherence tomography technique. Applications This method …

Pathological wound healing ex vivo model

In New services by Anja Borrosch

Wound healing is a highly complex dynamic process that involves the activation of several signalling pathways. In case of pathological environment such as age, diabetes and cancer, wound healing becomes more critical and can be chronically disrupted. We have developed …

Scalp UV irradiation ex vivo assay

In New services by Anja Borrosch

To understand the impact of UV (ultraviolet) irradiation on human hair follicle homeostasis is very important. We have developed a new ex vivo assay to investigate how solar UVR that hits the human scalp skin surface effects hair follicle physiology. …

Intravital visualization method of dynamic changes in human hair follicle cycle, and telogen hair follicle organ culture

In New services by Anja Borrosch

To reliably distinguish different phases of the hair cycle e.g. late catagen and telogen by stero-microscopy alone is challenging and requires histological analysis. In order to tackle this problem, we have established an intravital technique, based on meythelene blue staining, …

Investigation of nanotexture of corneocytes by atomic force microscopy

In New services by Anja Borrosch

Together with Serend-ip GmbH, Münster, Germany, we have launched a novel service for investigating the nanotexture of corneocytes by atomic force microscopy of  healthy human or atopic dermatitis skin organ culture ex vivo, or in the humanized model for atopic …

Human atopic dermatitis mouse model

In New services by Anja Borrosch

We collaborate with Prof. Dr. Amos Gilhar, Technion Israel Institute, Israel to develop a novel humanized mouse model for atopic dermatitis (AD). Our AD model recapitulates all the key features of the disease that are required for the preclinical development …